27 and about to start TRT. Freaked out with lots of questions!

Coptic

New Member


Hey everyone, chronic lurker on this and many other steroid boards, now an official newbie here.

Based a recent history of extreme fatigue (on top of my baseline hashimoto's hypothroid sleepiness) and lack of motivation/low libido, I had my testosterone, iron, and CBC checked out.
While my Iron study and CBC were normal, my test was pretty low (176). Had a secondary test level drawn two days later which was again low (253). Thanks to having a sister as a nurse practitioner and having all my labs covered by hospital insurance, I had a genetic karyotype ordered to rule out for Klinefelter's syndrome (primary hypogonadism) as well has having my FSH, LH, and prolactin all checked.

Test # 1=176 ng/dl
Free testosterone=3.15 ng/dl
Bio-available testosterone=99.2ng/dl
Test # 2=253 ng/dl

The karyotype was NEGATIVE for Klinefelter's and my FSH and LH were "inappropriately" low for a testosterone level that low, indicating secondary hypogonadism. My prolactin was normal.

SHBG=23 nmol/L
FSH=1.3
LH=3.1
Prolactin=9.7
Albumin=4.3 g/dl

A thyroid panel was also done (Mind you, I have not been on thyroid replacement meds [synthroid, etc] for months when the labs were drawn, but do have anti-TPO antibodies and have a confirmed family history of hashimoto's)
TSH: 3.647 milIU/ml
Total T3: 94 ng/dl
Free T4: 1.4 ng/dl

My new endo ordered a cosyntropin test, IGF-1, and basic metabolic panel, and while I don't have the labs in front of me, they were adequate (for the cosyntropin/cortisol response) and normal for the others. I had an estradiol and PSA ordered as well (my arm looks like I've been on a heroin binge the last three weeks from these pokes)
Estradiol: 30 pg/ml
PSA=0.5 ng/ml


So, at this point my endo is ordering the last CYA test which is a MRI of my sella to rule out a pituitary adenoma/cancer. She DOES want me to start TRT, and respects my input (my day job is in healthcare). Based on the maaaany late night searches (google's been kind), I'm interested in starting on testosterone injections (cypionate) at an initial dose of 100mg a week, plus HCG to minimize testicular atrophy as well as gaining the metabolic and synergistic side effects of HCG + Testosterone. I do have anastrazole on hand to minimize the effects that aromatizing the ADDITIONAL testosterone and the HCG. I know that with an estradiol level creeping close to high with my LOW level of testosterone will likely increase once I start injecting.

PLAN FOR TRT:
Test cyp=100mg IM weekly
HCG: 250 IU SC twice weekly (based of Crisler protocol) two days prior, one day prior to test inj.
Anastrazole 0.5mg every third day

In regards to any training and nutrition, I am by no means an expert. I am amazed and humbled by the knowledge, dedication, and experience that many of the users and moderators have on this sire. I have been training pretty consistently the last 2 years and have seen some gains for sure. But my efforts have really been hampered the last two months due to my lack of motivation. I have no one to blame but myself, but I am trying to get back into the groove. My diet is pretty clean with fresh veggies and about 70 gm of protein with a low carb lifestyle (I gain weight thinking about Panera).

Ht: 5'11
Wt: 165 lbs
BF: 14%

So now, my question to anyone kind enough to answer is this (excuse the large type): DOES THE BACKBONE OF MY TRT SEEM APPROPRIATE? ARE THERE AREAS WHERE i SHOULD REFOCUS OR LEARN MORE TO HELP DESIGN A BETTER PLAN?

I am aware that neither myself nor anyone else will be able to design the PERFECT initial cycle. I hope to get some very helpful feedback from the post and update this story with labs and a success story :o:D

Thanks in advance
-M
 
Seems like you need to get thyroid in order first. Why aren't you on thyroid meds?

"(Mind you, I have not been on thyroid replacement meds [synthroid, etc] for months when the labs were drawn, but do have anti-TPO antibodies and have a confirmed family history of hashimoto's)"
 
In regarded to mg thyroid meds I'm waiting for my follow up appointment with my endo this week to sort out both issues.
 
I have been on several different thyroid replacement s the past few years.synthroid, armour, westhroid...little change in symptoms.that's why I've switched endocrine doctors recently. Sorry for not stating that earlier.
 
I have been on several different thyroid replacement s the past few years.synthroid, armour, westhroid...little change in symptoms.that's why I've switched endocrine doctors recently. Sorry for not stating that earlier.

It seems as if hypothyroidism is as difficult to treat as low testosterone especially when T4 only meds are relied on. You must have a difficult case if combinations of T3 and T4 are not offering any relief.
 
I have been on several different thyroid replacement s the past few years.synthroid, armour, westhroid...little change in symptoms.that's why I've switched endocrine doctors recently. Sorry for not stating that earlier.
 
Tell me about it.from what I've read, correcting one deficiency without addressing the rest, especially in the case of idiopathic hypogonadotrophic hypogonadism is a receipe for misery! I'm hoping that by addressing both my thyroid and testosterone ill start to feel a bigger difference in the positive aspects. Any critique on my try proposal?
 
Your testosterone and HCG seem right, but knowing what I know about estradiol, you might/will probably need to adjust your anatrozole (Arimidex) dosing based on labs and feel.

Also, doesn't Chrisler prescribe pregnenolone with his TRT patients, too? I haven't researched why, or people's subjective opinions of it, but it's worth looking into if you've committed to make a life-long decision like this by getting onto TRT. All your bases need to be covered.
 
From Dr. Crisler:

"I nearly always add HCG, DHEA and pregnenolone to the TRT regimen. Inserting these hormones helps restore natural hormonal pathways, "backfilling" them, if you will, once we have suppressed the HPTA with TRT. We will probably never know all the intermediary steps in these pathways, much less all the actions of each substance upon the body. In my professional opinion, this is the current state-of-the-art in TRT medicine."

TESTOSTERONE NATION | Any of You Use Pregnenolne and DHEA? - Page 1

--> Check out DHEA, too, not just pregnenolone.
 
So after hearing from my "expert" of an endocrinologist that she won't switch me from IM to any other formulation on TRT, I've found another MD who specializes in HRT around my area. He is a guy so I'm hoing he's bit more sensitive to a few of my male/sex related issues than she was.

With the expectation that he is more versed in TRT protocols, what would be the best meds and formulations to strt off with? From what I have heard from his assistant, he does like to use compounded creams as his delivery system.

HCG + test creame? HCG only? test only?

thanks in advance

-m
 
as a follow-up, my free T on 50mg of test/weekly =371ng/dl.

dont feel a bit better but morning wood is there (i think more than pre-TRT)
 
HCG + test creame? HCG only? test only?

thanks in advance

-m

I believe in keeping things simple. I would suggest test only. Then if you continue to have problems, you can add other things if needed. Why try to fix what isn't broken?
However, most of us will suggest what worked for us.
 
Why would you bother with injecting testosterone when your body is completely capable of making it?

Use hCG alone.
 
Update:

Found a new , MALE (i swear it makes a world of difference) endocrinologist who really knows his stuff.
He was keen on the HCG +testosterone therapy combination for TRT before I was even able to get a word in.

He started me on 1ml of a compounded 10% testosterone cream and 250mcg of HCG 2x per week.

Keeping in mind that my pre-treatment TT was around 200.....

My latest numbers after 2 wks of treatment are as follows:

TT: 609 ng/dL
Estradiol: 31 pg/ml (taking 1mg of arimidex twice weekly)
SHBG: 41 nmol/L


My pre-treatment estradiol and SHBG were:

Estradiol: 30 pg/ml
SHBG: 23 nmol/L

So, while my estradiol has remained "normal" (however, this is WITH the addition of the arimidex, and most likely my E2 is a bit higher when unchecked by an AI), my SHBG has almost doubled.

Syptomatically, I must say I have never been this exhaused in my life. My energy crashes around 3-5 PM requiring a 1-2 hr nap, then muddling through the rest of the night partially asleep. I don't notice a surge of energy or pump when working out. I do have a bit more morningwood, but my libido is still marginal at best.

I admit my ignorance of understanding a lot of TRT related issues, and I know that there are many intelligent and insightful members on this forum who may be able to lend some wisdom with my case. I'd just like to have a bit of backup knowledge when I go in for my appointment on Monday afternoon.

As always, any constructive info is much appreciated.

gb
 
Different people respond to TRT in different ways, but feeling wiped isn't typically one of them.

When I see "Hashi's" and "still fatigued" I immediately suggest two things:

1. Get a celiac test.
2. Get your cortisol checked.

Your endo should be on the case at least as far as #2, but not all of them are, and a midafternoon crash can be a sign that you're hypoadrenal. It's less likely that anyone but an academic endo or PubMed-reading nerd would think to ask about #1 (I'm a pubmed-reading nerd whose endo is a med school prof), but if you have Hashi's your odds of having celiac are something like 10-15 times above average, and dealing with it now could save you from bigger troubles (troubles like MS, Addison's, lupus...) later on. It's also something that could leave you feeling better in a hurry once corrected.
 

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