parabbuilding
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MESO-Rx
Anabolic Steroids
about ORIMETEN
- Thread starter parabbuilding
- Start date
parabbuilding
New Member
How does it work?
Aminoglutethimide prevents the production of steroid hormones in the adrenal cortex. This occurs at an early stage in the process. Aminoglutethimide may also suppress the production of oestrogens elsewhere in the body.
Some types of cancer, especially breast cancer, will grow in the presence of oestrogens. Reduction of oestrogen levels will limit the growth of this type of cancer. Aminoglutethimide can be used for this purpose.
As aminoglutethimide also inhibits production of cortisone, it can also be used in the treatment of Cushing's syndrome.
What is it used for?
Breast cancer
Cushing's syndrome caused by a tumor
Warning!
People taking this medicine should have regular blood tests.
It is recommended that blood tests are performed every six months to check the levels of thyroid hormones in the blood (thyroid function tests).
Blood pressure should be monitored regularly during treatment with this medicine.
Use with caution in
Lack of production of natural steroid hormones from the adrenal gland (adrenocortical insufficiency)
Not to be used in
Breastfeeding
Known sensitivity or allergy to any ingredient
Life long inherited blood diseases which can cause a variety of symptoms, including mental health problems (porphyrias)
Pregnancy
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
This medicine should not be used during pregnancy as it may be harmful to the unborn baby. Seek medical advice from your doctor.
Significant amounts of this medicine may pass into breast milk. It should not be used by breastfeeding mothers as it may be harmful to the nursing infant. Seek medical advice from your doctor.
Label warnings
This medication may cause drowsiness. If affected do not drive or operate machinery. Avoid alcoholic drink.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Rash
Drowsiness
Nausea
Blood disorders
Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
Decreased functioning of the adrenal gland (adrenal suppression)
Dizziness
Tiredness (lethargy)
An extreme allergic reaction (anaphylaxis)
Shaky movements and unsteady walk (ataxia)
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
Aminoglutethimide increase the breakdown of the following medicines and therefore may reduce their effects:
blood-thinning / anti-clotting medicines (e.g. nicoumalone and warfarin).
oral anti-diabetic medicines
dexamethasone
Bodybuilding use:
names
rimeten/aminogluthetimide/cytadren/rogluten
Cytadren is not an anabolic/androgenic steroid. Cytadren inhibits the buildup of androgens, estrogens, and the suprarenal cortical hormones (glucocorticoids and mineralocor-ticoids). Cytadren has a highly antiestrogenic effect since, on the one hand, it inhibits the body's own estrogen production and, on the other hand, it obviates the conversion of androgens into estrogens. This is especially en-couraging since it helps to keep the estrogen level of bodybuilders low. The second highly interesting point is that Cytadren prohibits the buildup of adrenocortical hormones. It obviates the production of endogenous cortisone like no other compound by inhibiting the conversion of cholesterol into cortisone. For this reason, Cytadren, in school medicine, is used for the treatment of Cushing's syndrome, a hyperfunction of the adrenal glands which causes the body to overproduce cortisone. Consequently, it reduces the cortisone level, which has several advantages for the athlete. Cortisone is a cata-bolic hormone and catabolic is the exact opposite of anabolic. Corti-sone prevents the protein synthesis in the muscle cell, resulting in a muscular atrophy by breaking down amino acids in the muscle cell.
The human body constantly releases cortisone and reacts to stress situations such as intense training by increasing its cortisone re-lease. Natural bodybuilders, therefore, after a short time, experience a stagnation in their development since the release of the body's cortisone is higher than the anabolic effect of working out. The more advanced the athlete and the harder his workout, the more his cor-tisone level will increase.
If the release of cortisone can be successfully obviated or at least considerably reduced the ratio of anabolic hormones to catabolic hormones in the body shifts in favor of the former. This results in an increase in muscle mass and body strength. And Cytadren achieves exactly these results; however, there is one problem. Cytadren reduces the cortisone level so effectively that the body tries to balance this by hypophysially producing more ACTH (adenocorticotropic hormone), thus stimulating the secretion of cortisone by the adrenal glands. Thus in school medicine, when treating Cushing's syndrome, a low dose of oral hydrocortisone is used to prevent the hypophysis from producing ACTH. The dose is so low that the cortisone level in the blood does not rise substantially. And this is exactly the problem. Cytadren reduces the cortisone level which the body balances by producing ACTH, thus neutralizing the effect of Cytadren. If exogenous hydrocor-tisone is taken no ACTH is produced; however, this also reduces the effect of Cytadren. It is therefore necessary to find an admin-istration schedule that prevents or delays the body's own pro-duction of ACTH. Since the body does not show abrupt reactions when the cortisone level is lowered by the intake of Cytadren, the compound must be taken over several days before the body be-gins reacting. If Cytadren is only taken for a period of two days and then discontinued for two entire days, it seems logical that the body will not have enough time to react accordingly, thus interrupting the production of ACTH in the hypophysis. Similar to Clenbuterol, an alternating administration schedule with two days of administration and two days of abstinence is created. Another problem needs to be solved since Cytadren, as mentioned earlier, inhibits the body's own production of androgen. Cytadren, therefore, should not be used by natural bodybuilders. The solu-tion to this problem is to take a long-term effective testosterone such as Testosterone enanthate simultaneously. Testoviron Depot 250, for example, can be considered as one such possible com-pound.
As for the question of dosage, we have arrived at a very interesting point. In school medicine the dosage for the treatment of Cushing's syndrome is between 2 and 7 tablets per day. Since not enough ath-letes~ have used this compound so far, we do not have enough ex-perimental data. Due to the fact that the cortisone level of athletes is not as high as in persons who suffer from a hyperfunction of the adrenal glands, it is probable that lower dosages are sufficient. A dose of mor than 250mg/day is not recommended and should be taken very carefully. A good example of dose is: half a tab 125mg in the morning and 62.5mg (quarter tab) every six hours. Make sure to not abruptly discontinure as cortisol rebound may occur. The tablets are always taken indi-vidually, in regular intervals throughout the day, and taken best during meals. How long should it be taken? This ques-tion is difficult to answer but, considering that the body can-some-times increase the production of ACTH, it is advised that the com-pound is not used longer than 4-6 weeks. (We must also consider potential side effects, which we will discuss in a minute.) An-other interesting aspect: Cytadren is (as of yet) not on any dop-ing list. We have heard from reliable informants that a combina-tion of Cytadren, growth hormones, and a low quantity of in-jectable testosterone is the new hit among athletes of any field, since it allows the athlete to pass any doping test.
Thus the side effects of Cytadren need to be looked at and they are, unfortunately, numerous and sometimes very severe. The most common side effects are fatigue and dizziness. Lack of con-centration, restlessness, depression, apathy, and sleeping disorder are less common but possible. Even rarer and mostly depending on the doses are nausea, vomiting, gastrointestinal pain, diar-rhea, and headaches. A possible rash and the already-mentioned fatigue and dizziness are usually initial symptoms and these can be minimized by taking slowly increasing dosages, or they may simply disappear. The package insert of Ciba-Geigy GmbH Ger-many also states that in some cases there is an inadequate thy-roid function which requires treatment. It is therefore recom-mended that the thyroid gland be supervised by a physician dur-ing intake of Cytadren. Another problem that can occur is liver disease. Cases of reduced counts of the white blood cells, the blood platelets, and even of all blood cells have been reported. Those who plan to try Cytadren should carefully read the package in-sert. It has been our experience that athletes, due to the reduced cortisone level, complain about joint pain and are also exposed to a higher risk of getting injured. There is no question that Cytadren is effective when taken according to the two-day alternating ad-ministration schedule; however, the athlete should carefully con-sider the cost/benefit factor prior to taking the compound. Cytadren is in U.S. pharmacies only available by prescription. Cytadren is rarely found on the black market.
Aminoglutethimide prevents the production of steroid hormones in the adrenal cortex. This occurs at an early stage in the process. Aminoglutethimide may also suppress the production of oestrogens elsewhere in the body.
Some types of cancer, especially breast cancer, will grow in the presence of oestrogens. Reduction of oestrogen levels will limit the growth of this type of cancer. Aminoglutethimide can be used for this purpose.
As aminoglutethimide also inhibits production of cortisone, it can also be used in the treatment of Cushing's syndrome.
What is it used for?
Breast cancer
Cushing's syndrome caused by a tumor
Warning!
People taking this medicine should have regular blood tests.
It is recommended that blood tests are performed every six months to check the levels of thyroid hormones in the blood (thyroid function tests).
Blood pressure should be monitored regularly during treatment with this medicine.
Use with caution in
Lack of production of natural steroid hormones from the adrenal gland (adrenocortical insufficiency)
Not to be used in
Breastfeeding
Known sensitivity or allergy to any ingredient
Life long inherited blood diseases which can cause a variety of symptoms, including mental health problems (porphyrias)
Pregnancy
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
This medicine should not be used during pregnancy as it may be harmful to the unborn baby. Seek medical advice from your doctor.
Significant amounts of this medicine may pass into breast milk. It should not be used by breastfeeding mothers as it may be harmful to the nursing infant. Seek medical advice from your doctor.
Label warnings
This medication may cause drowsiness. If affected do not drive or operate machinery. Avoid alcoholic drink.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Rash
Drowsiness
Nausea
Blood disorders
Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
Decreased functioning of the adrenal gland (adrenal suppression)
Dizziness
Tiredness (lethargy)
An extreme allergic reaction (anaphylaxis)
Shaky movements and unsteady walk (ataxia)
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
Aminoglutethimide increase the breakdown of the following medicines and therefore may reduce their effects:
blood-thinning / anti-clotting medicines (e.g. nicoumalone and warfarin).
oral anti-diabetic medicines
dexamethasone
Bodybuilding use:
names
rimeten/aminogluthetimide/cytadren/roglutenCytadren is not an anabolic/androgenic steroid. Cytadren inhibits the buildup of androgens, estrogens, and the suprarenal cortical hormones (glucocorticoids and mineralocor-ticoids). Cytadren has a highly antiestrogenic effect since, on the one hand, it inhibits the body's own estrogen production and, on the other hand, it obviates the conversion of androgens into estrogens. This is especially en-couraging since it helps to keep the estrogen level of bodybuilders low. The second highly interesting point is that Cytadren prohibits the buildup of adrenocortical hormones. It obviates the production of endogenous cortisone like no other compound by inhibiting the conversion of cholesterol into cortisone. For this reason, Cytadren, in school medicine, is used for the treatment of Cushing's syndrome, a hyperfunction of the adrenal glands which causes the body to overproduce cortisone. Consequently, it reduces the cortisone level, which has several advantages for the athlete. Cortisone is a cata-bolic hormone and catabolic is the exact opposite of anabolic. Corti-sone prevents the protein synthesis in the muscle cell, resulting in a muscular atrophy by breaking down amino acids in the muscle cell.
The human body constantly releases cortisone and reacts to stress situations such as intense training by increasing its cortisone re-lease. Natural bodybuilders, therefore, after a short time, experience a stagnation in their development since the release of the body's cortisone is higher than the anabolic effect of working out. The more advanced the athlete and the harder his workout, the more his cor-tisone level will increase.
If the release of cortisone can be successfully obviated or at least considerably reduced the ratio of anabolic hormones to catabolic hormones in the body shifts in favor of the former. This results in an increase in muscle mass and body strength. And Cytadren achieves exactly these results; however, there is one problem. Cytadren reduces the cortisone level so effectively that the body tries to balance this by hypophysially producing more ACTH (adenocorticotropic hormone), thus stimulating the secretion of cortisone by the adrenal glands. Thus in school medicine, when treating Cushing's syndrome, a low dose of oral hydrocortisone is used to prevent the hypophysis from producing ACTH. The dose is so low that the cortisone level in the blood does not rise substantially. And this is exactly the problem. Cytadren reduces the cortisone level which the body balances by producing ACTH, thus neutralizing the effect of Cytadren. If exogenous hydrocor-tisone is taken no ACTH is produced; however, this also reduces the effect of Cytadren. It is therefore necessary to find an admin-istration schedule that prevents or delays the body's own pro-duction of ACTH. Since the body does not show abrupt reactions when the cortisone level is lowered by the intake of Cytadren, the compound must be taken over several days before the body be-gins reacting. If Cytadren is only taken for a period of two days and then discontinued for two entire days, it seems logical that the body will not have enough time to react accordingly, thus interrupting the production of ACTH in the hypophysis. Similar to Clenbuterol, an alternating administration schedule with two days of administration and two days of abstinence is created. Another problem needs to be solved since Cytadren, as mentioned earlier, inhibits the body's own production of androgen. Cytadren, therefore, should not be used by natural bodybuilders. The solu-tion to this problem is to take a long-term effective testosterone such as Testosterone enanthate simultaneously. Testoviron Depot 250, for example, can be considered as one such possible com-pound.
As for the question of dosage, we have arrived at a very interesting point. In school medicine the dosage for the treatment of Cushing's syndrome is between 2 and 7 tablets per day. Since not enough ath-letes~ have used this compound so far, we do not have enough ex-perimental data. Due to the fact that the cortisone level of athletes is not as high as in persons who suffer from a hyperfunction of the adrenal glands, it is probable that lower dosages are sufficient. A dose of mor than 250mg/day is not recommended and should be taken very carefully. A good example of dose is: half a tab 125mg in the morning and 62.5mg (quarter tab) every six hours. Make sure to not abruptly discontinure as cortisol rebound may occur. The tablets are always taken indi-vidually, in regular intervals throughout the day, and taken best during meals. How long should it be taken? This ques-tion is difficult to answer but, considering that the body can-some-times increase the production of ACTH, it is advised that the com-pound is not used longer than 4-6 weeks. (We must also consider potential side effects, which we will discuss in a minute.) An-other interesting aspect: Cytadren is (as of yet) not on any dop-ing list. We have heard from reliable informants that a combina-tion of Cytadren, growth hormones, and a low quantity of in-jectable testosterone is the new hit among athletes of any field, since it allows the athlete to pass any doping test.
Thus the side effects of Cytadren need to be looked at and they are, unfortunately, numerous and sometimes very severe. The most common side effects are fatigue and dizziness. Lack of con-centration, restlessness, depression, apathy, and sleeping disorder are less common but possible. Even rarer and mostly depending on the doses are nausea, vomiting, gastrointestinal pain, diar-rhea, and headaches. A possible rash and the already-mentioned fatigue and dizziness are usually initial symptoms and these can be minimized by taking slowly increasing dosages, or they may simply disappear. The package insert of Ciba-Geigy GmbH Ger-many also states that in some cases there is an inadequate thy-roid function which requires treatment. It is therefore recom-mended that the thyroid gland be supervised by a physician dur-ing intake of Cytadren. Another problem that can occur is liver disease. Cases of reduced counts of the white blood cells, the blood platelets, and even of all blood cells have been reported. Those who plan to try Cytadren should carefully read the package in-sert. It has been our experience that athletes, due to the reduced cortisone level, complain about joint pain and are also exposed to a higher risk of getting injured. There is no question that Cytadren is effective when taken according to the two-day alternating ad-ministration schedule; however, the athlete should carefully con-sider the cost/benefit factor prior to taking the compound. Cytadren is in U.S. pharmacies only available by prescription. Cytadren is rarely found on the black market.
biganth
New Member
I didnt read the above links,but one thing you have to be careful of the Aminogluthamide is the Cortisol rebound effect if you take too much for too long
