Albuterol Dose?

[Equinob]

It looks like the average recommended dose for Albuterol is around 16mg-24mg dosed 4x/day, every 4 hours, based on a half-life of the drug around 3-4 hours.

I did a quick half-life chart which based on that formula at 16mg/day (4mg ever 4 hours), gives me the following levels throughout the day:

6AM - (+4mg) 4mg
10AM - (+4mg) 6mg
2PM - (+4mg) 7mg
6PM - (+4mg) 7.5mg
10PM - 3.75mg
2AM - 1.87mg

And then the cycle repeats. So those 8 hours overnight where I'm not dosing sees a huge drop in blood levels.

So the question is, how important is it to maintain steady levels of Albuterol for maximum effect? It seems like maybe we should be dosing at least 5x/day so that my levels stay a little more consistent at 4-7mg, rather than a huge drop to less than 1mg overnight. At 4mg/dose this would easily put me at 20mg/day range (I was gonna half to add half-tabs per dose, for 6mg/dose, to get up to 24mg/day).

 

[Dr JIM]

The answer depends, in large part, upon what your trying to accomplish by using Albuterol?

On second glance what is all that silliness about, it's dosed EVERY FOUR HOURS bc THE HALF LIFE IS FOUR HOURS!

If this is done steady state levels well be reached in roughly ONE DAY!

 

[Equinob]

The answer depends, in large part, upon what your trying to accomplish by using Albuterol?

On second glance what is all that silliness about, it's dosed EVERY FOUR HOURS bc THE HALF LIFE IS FOUR HOURS!

If this is done, steady state levels well be reached in roughly ONE DAY!

I'm taking it to lose fat. Everything I've read recommends taking it 2-4 times a day, due to the short half-life of 3-4 hours. I chose every four hours since that easily falls within my waking hours, and easy to remember, but it also corresponds to the drug's half-life.

I'm not sure I follow your point about the steady state being reached in one day. The calculations I posted above shows a steady state reached in about 8 hours, but drops below 1mg before the next day's dose. If I'm suffering a misunderstanding here, I'd love to be set straight.

 

[Jimmyinkedup]

I take it 2x/day.
Usually 6mg/dose for a total of 12mg/day.
Many run double that. The most I run is 18mg/day split into 2-9mg doses but that is rare.
When I use it for a pre workout I use 3-6mg depending.

 

[Arnold Strong]

So those 8 hours overnight where I'm not dosing sees a huge drop in blood levels.

That's a feature, you can enjoy your 8 hours of sleep without the stimulant effect of the drug affecting you.

 

[Equinob]

I take it 2x/day.
Usually 6mg/dose for a total of 12mg/day.
Many run double that. The most I run is 18mg/day split into 2-9mg doses but that is rare.
When I use it for a pre workout I use 3-6mg depending.

Your tabs must be 3 or 6mg. Mine are 4mg which is why I go in multiples of 2 (unless I want to start quartering my tabs).

Yours is typical of what I've seen, though most advise greater than 12mg/day, as you point out, depending on tolerances. I was wondering about using this as a pre-workout, so I'm glad to see you find it useful for that purpose.

That said, looking at the half life cycle between your doses, your initial 6mg dose has dropped below 1mg by the time you take your second dose (assuming 6AM & 6PM), essentially giving you a big spike every 12 hours.

Obviously this works for you, but I'm wondering if those big spikes matter ... is the drug more effective at steady levels throughout the day, or am I getting this confused with maintaining steady-state hormone levels with AAS?

 

[Equinob]

That's a feature, you can enjoy your 8 hours of sleep without the stimulant effect of the drug affecting you.

Ha, I thought about that. I'm taking ketotifen at night, which tends to counteract that.

But otherwise, is the trade off reduced fat burning during sleep, and is that even relevant to such a cycle? I'm certainly not going to get up during the middle of the night to keep my levels steady unless there were a massive payoff!

 

[Dr JIM]

I hope you don't believe consuming a Beta agonist is just going to "melt the fat away" bc the effects, especially in the absence of exercise and a proper diet, are negligible at best.

Don't believe me, take a look at those who use BAs EVRY DAY and at high doses such as COPD or "emphysema" patients!

 

[Equinob]

I hope you don't believe consuming a Beta agonist is just going to "melt the fat away" bc the effects, especially in the absence of exercise and a proper diet, are negligible at best.

Don't believe me, take a look at those who use BAs EVRY DAY and at high doses such as COPD or "emphysema" patients!

I'm not sue what I said to indicate that? I just came off a cutting cycle using T3 but the catabolic properties of that drug were not appropriate for continued use off AAS. So I looked at Albuterol as a purportedly anti-catabolic alternative to drop the last 1-2% of body fat I'd like to shed during y PCT. I'm in the gym 7 days a week, I'm eating clean, and at a slight deficit, with some cardio ED and above average active lifestyle. I can tell you that after almost two weeks on the drug and PCT, I have noticed strength gains over where I was lifting with AAS.

In light of that, is it your opinion that Albuterol is a completely pointless drug to use for this purpose?

 

[Dr JIM]

I'm not sue what I said to indicate that? I just came off a cutting cycle using T3 but the catabolic properties of that drug were not appropriate for continued use off AAS. So I looked at Albuterol as a purportedly anti-catabolic alternative to drop the last 1-2% of body fat I'd like to shed during y PCT. I'm in the gym 7 days a week, I'm eating clean, and at a slight deficit, with some cardio ED and above average active lifestyle. I can tell you that after almost two weeks on the drug and PCT, I have noticed strength gains over where I was lifting with AAS.

In light of that, is it your opinion that Albuterol is a completely pointless drug to use for this purpose?

I assume nothing on this forum especially the objective or intent of any PED user. To that end, why do you believe I mentioned "fat cutting"? Bc Meso has A LOT of very inexperienced spectators whom are prone to misinterpreting posts that "look good" or are otherwise poorly defined and some are no doubt in search of the ideal weight loss agent.

What agent is that? One which is effective in pill form, is relatively inexpensive, exhibits mild side effects, and requires minimal to no PHYSICAL EFFORT (except walking to a couch) to reach the desired end point.

Sounds a lot like Beta agonsits does it not? Well at least that's how I've heard of them being touted on many forums and by "supplement" resellers.

Except it's not evidence based bc of one huge problem, the development of beta receptor desensitization to the effects of these agents. And unfortunately such tachyphylaxis doesn't take very long either, as little as one week in some studies.

So can they be used as adjunctive therapy by BB as a means of enhancing a "cutting cycle", I suspect so (bc the evidence also shows these agents can enhance lipolysis, fat oxidation and insulin sensitivity) but such effects are short lived as I mentioned earlier. However these agents should not be considered a viable substitute for what is a well established means of fat reduction, AEROBIC ACTIVITY.

Nonetheless, if the broad class of agents commonly referred to as beta agonists are used, optimal "benefit" is likely limited to no more than one or perhaps two weeks, based on the data I've reviewed.

 

[Equinob]

I assume nothing on this forum especially the objective or intent of any PED user. To that end, why do you believe I mentioned "fat cutting"? Bc Meso has A LOT of very inexperienced spectators whom are prone to misinterpreting posts that "look good" or are otherwise poorly defined and some are no doubt in search of the ideal weight loss agent.

What agent is that? One which is effective in pill form, is relatively inexpensive, exhibits mild side effects, and requires minimal to no PHYSICAL EFFORT (except walking to a couch) to reach the desired end point.

Sounds a lot like Beta agonsits does it not? Well at least that's how I've heard of them being touted on many forums and by "supplement" resellers.

Except it's not evidence based bc of one huge problem, the development of beta receptor desensitization to the effects of these agents. And unfortunately such tachyphylaxis doesn't take very long either, as little as one week in some studies.

So can they be used as adjunctive therapy by BB as a means of enhancing a "cutting cycle", I suspect so (bc the evidence also shows these agents can enhance lipolysis, fat oxidation and insulin sensitivity) but such effects are short lived as I mentioned earlier. However these agents should not be considered a viable substitute for what is a well established means of fat reduction, AEROBIC ACTIVITY.

Nonetheless, if the broad class of agents commonly referred to as beta agonists are used, optimal "benefit" is likely limited to no more than one or perhaps two weeks, based on the data I've reviewed.

I agree with your assessment of using a beta agonist. I had planned only to run the Albuterol for four weeks. Having read much of the same conclusions that the beta receptors are desensitized within two weeks max. requiring a minimum two week break in use, or the addition of something like Ketotifen to upregulate the beta-receptors, which is what I'm doing. According to everything I've read this seems to be a way around that inherent problem with using beta agonists, and Ketotifen may have other benefits during PCT, so I'm taking it every night since I started the Albuterol.

Does your research suggest that Ketotifen will not function in this respect, and I should limit my use of Albuterol to two weeks, at the most?

And assuming you agree with my use of Albuterol as I"ve outlined, does that mean you also agree with my dosing strategy per my OP? Or is it still your opinion that dosing the drug every 4 hours corresponding with the half-life is irrelevant to its use for this purpose?

 

[FockU]

bump

 

[TruthSeeker2015]

Bump x2.

I'd like to know if this beta antagonist effect applies to the ECA stack as well; if anyone knows that is.

 

[ecdysone]

Actually the half-life is 5-6 hours and one must remember that after just 3 doses a
"steady state" level will be reached in which the trough concentrations are relatively higher and constant compared to a single dose level. Dosing at 6 hr increments is the correct regime but skipping a dose will still result in a decent blood level.