Anyone with Reta drug-drug interactions?

[RockyP]

Brothers,

In the very early stages of maybe possibly switching from tirz to Reta (appetite suppression on even 5 mg tirz is getting crazy and I’m on a cut and still can’t eat enough).

One thing that gives me pause is the unknowns about drug drug interactions with Reta. While reta has some similar actions as Tirz and sema, they are all different molecules and drug drug interactions from one cannot be extrapolated to the other.

Curious if others have experienced any significant drug - drug interactions. May main concern would be with Armour thyroid which I take. There is a theoretical drug drug interaction between Armour and tirz which I already take (could antagonize tirz) but that’s def not happening clinically for me.

 

[Ghoul]

Brothers,

In the very early stages of maybe possibly switching from tirz to Reta (appetite suppression on even 5 mg tirz is getting crazy and I’m on a cut and still can’t eat enough).

One thing that gives me pause is the unknowns about drug drug interactions with Reta. While reta has some similar actions as Tirz and sema, they are all different molecules and drug drug interactions from one cannot be extrapolated to the other.

Curious if others have experienced any significant drug - drug interactions. May main concern would be with Armour thyroid which I take. There is a theoretical drug drug interaction between Armour and tirz which I already take (could antagonize tirz) but that’s def not happening clinically for me.

There are no absolutely contraindicated medications with GLP-1 agonists. Because GLP-1s mimic natural gut hormones, no new interactions are being introduced, including with Reta's glucagon.

The only potential issues are related to slowed gastric emptying changing timing or absorption exposure(more absorption), and additive effects from other glucose lowering meds.

So for example on a thyroid med, if you feel different recheck levels to see if the dose should be lowered, birth control use a backup, and if using metformin or insulin stay on alert for hypoglycemia.

Of course you've been through this on Tirz, Reta won't be any different in this respect.

 

[RockyP]

There are no absolutely contraindicated medications with GLP-1 agonists. Because GLP-1s mimic natural gut hormones, no new interactions are being introduced, including with Reta's glucagon.

The only potential issues are related to slowed gastric emptying changing timing or absorption exposure(more absorption), and additive effects from other glucose lowering meds.

So for example on a thyroid med, if you feel different recheck levels to see if the dose should be lowered, birth control use a backup, and if using metformin or insulin stay on alert for hypoglycemia.

Of course you've been through this on Tirz, Reta won't be any different in this respect.

Massively helpful. I suppose it wouldn’t be a great idea to start thyroid meds with Reta at the same time due to heart rate effects (ie if you had increased HR after starting both at the same time you wouldn’t know what did it). But I’m on a low dose that’s been stable for years. And adding tirz didn’t alter my free t3

 

[Ghoul]

Massively helpful. I suppose it wouldn’t be a great idea to start thyroid meds with Reta at the same time due to heart rate effects (ie if you had increased HR after starting both at the same time you wouldn’t know what did it). But I’m on a low dose that’s been stable for years. And adding tirz didn’t alter my free t3

I think it's always a good idea to only introduce one new drug at a time, allow things to stabilize, so you don't complicate troubleshooting if there's an issue.

I started T4 after Tirz, and had to lower the Tirz dose because the additional appetite suppression from optimizing T4 levels was too much, though it eventually settled down and I could resume my previous dose of Tirz.

 

[Liter O' Test]

you get pharma tirz, you cant throw in the towel already on week 3. i dont even buy into reta supressing appetite less than tirz, because everyone using reta uses sub 3mg doses anyway

 

[RockyP]

you get pharma tirz, you cant throw in the towel already on week 3. i dont even buy into reta supressing appetite less than tirz, because everyone using reta uses sub 3mg doses anyway

It’s been just over 7 weeks. I did 4 weeks of 2.5 and I’m finishing up my month of 5, with the plan to go to 7.5. Just keeping options open. Several Reta users I’ve spoken with who switched from tirz had similar sides from tirz that they no longer have with Reta. I’m around 240 and it’s hard to get 2000 cals in. It’s not a bad thing per se. But half the week is also spent with reflux / Gerd and feelings of malaise / fatigue. Usually the 24-36 hours after each shot (take 2.5 twice per week). By the time the sides wear off, I’m ready for another pin.

 

[Liter O' Test]

It’s been just over 7 weeks. I did 4 weeks of 2.5 and I’m finishing up my month of 5, with the plan to go to 7.5. Just keeping options open. Several Reta users I’ve spoken with who switched from tirz had similar sides from tirz that they no longer have with Reta. I’m around 240 and it’s hard to get 2000 cals in. It’s not a bad thing per se. But half the week is also spent with reflux / Gerd and feelings of malaise / fatigue. Usually the 24-36 hours after each shot (take 2.5 twice per week). By the time the sides wear off, I’m ready for another pin.

dang, i guess ill titrate slower then, i dont want to be in your shoes. I'd shrivel up a week or two at 2k

 

[RockyP]

dang, i guess ill titrate slower then, i dont want to be in your shoes. I'd shrivel up a week or two at 2k

Luckily I’m holding tissue with 500 mg and 4 iu daily. Strength is holding for now. But this can’t go on forever. I’m going to keep at it before switching. Can always switch at any time. These minor sides may we dissipate over time also. And for all the hoopla surrounding Reta the data only shows 5% more weight loss vs Tirz. And that’s weight loss in average joes. Idk how those numbers would stack up in our population of lifters eating properly with PEDs to stave off muscle loss.

 

[Liter O' Test]

Luckily I’m holding tissue with 500 mg and 4 iu daily. Strength is holding for now. But this can’t go on forever. I’m going to keep at it before switching. Can always switch at any time. These minor sides may we dissipate over time also. And for all the hoopla surrounding Reta the data only shows 5% more weight loss vs Tirz. And that’s weight loss in average joes. Idk how those numbers would stack up in our population of lifters eating properly with PEDs to stave off muscle loss.

you get any sharp pain left side of abdomen?
Maybe cause i increased fats recently along with tirz or im just constipated

 

[RockyP]

you get any sharp pain left side of abdomen?
Maybe cause i increased fats recently along with tirz or im just constipated

Haven’t had that. Upper or lower quadrant? If upper quadrant I’d be mindful of pancreatitis.

 

[RockyP]

Just realized that the recommended maintenance dosage of tirz for OSA (which is why I was prescribed it) is 10-15 mg weekly. So I’m going to keep running this for another several months at least. Perhaps indefinitely. Can always go to Reta whenever.

 

[OldGHGuy]

It’s been just over 7 weeks. I did 4 weeks of 2.5 and I’m finishing up my month of 5, with the plan to go to 7.5. Just keeping options open. Several Reta users I’ve spoken with who switched from tirz had similar sides from tirz that they no longer have with Reta. I’m around 240 and it’s hard to get 2000 cals in. It’s not a bad thing per se. But half the week is also spent with reflux / Gerd and feelings of malaise / fatigue. Usually the 24-36 hours after each shot (take 2.5 twice per week). By the time the sides wear off, I’m ready for another

I am planning to switch from Tirz 5mg to Reta just as an experiment to see how I react. Tirz at 5mg gives me mild appetite suppression and keeps my weight within 2-3 pounds of 270, regardless of what I eat. I also get mild to occasionally moderate stomach pain/bloating on and off throughout the week. Interested to see what Reta does. I plan to start at 2mg

 

[RockyP]

I am planning to switch from Tirz 5mg to Reta just as an experiment to see how I react. Tirz at 5mg gives me mild appetite suppression and keeps my weight within 2-3 pounds of 270, regardless of what I eat. I also get mild to occasionally moderate stomach pain/bloating on and off throughout the week. Interested to see what Reta does. I plan to start at 2mg

I just switched To Reta 2 mg weekly also. Tirz was fine but appetite suppression was excessive and post injection fatigue was annoying. I was also impressed by the data showing supremacy of Reta re: serum lipids and fatty liver infiltrates (above and beyond the effect of weight loss).

 

[Gord0]

I just switched To Reta 2 mg weekly also. Tirz was fine but appetite suppression was excessive and post injection fatigue was annoying. I was also impressed by the data showing supremacy of Reta re: serum lipids and fatty liver infiltrates (above and beyond the effect of weight loss).

How is your energy level with Reta?

 

[RockyP]

How is your energy level with Reta?

Phenomenal. Should’ve switched a long time ago.

 

[quarter]

Slow gastric draining sucks for oral meds

 

[RockyP]

I haven’t seen any changes on my thyroid labs taking my NDT pre GLP-1 and post.