BAC water from QSC is only 0.8% BA not 0.9%, does it matter?

[bryan_usa]

I noticed that QSC's bacteriostatic (BAC) water is listed at 0.8% Benzyl Alcohol rather than the usual 0.9% Benzyl Alcohol. Do you think that matters when reconstituting things like HCG, peptides or tirzepatide? I'm guessing the only issue is whether that's enough BA to kill bacteria in the vial long term, correct?

 

[bryan_usa]

I noticed that QSC's bacteriostatic (BAC) water is listed at 0.8% Benzyl Alcohol rather than the usual 0.9% Benzyl Alcohol. Do you think that matters when reconstituting things like HCG, peptides or tirzepatide? I'm guessing the only issue is whether that's enough BA to kill bacteria in the vial long term, correct?

 

[bryan_usa]

Any opinions on QSC's bacteriostatic water and BA percentage being lower than others?

 

[Deskoze38192]

Any opinions on QSC's bacteriostatic water and BA percentage being lower than others?

Obviously not

 

[Deskoze38192]

You related to the 10.2541 vial guy?

 

[HB_22]

I noticed that QSC's bacteriostatic (BAC) water is listed at 0.8% Benzyl Alcohol rather than the usual 0.9% Benzyl Alcohol. Do you think that matters when reconstituting things like HCG, peptides or tirzepatide? I'm guessing the only issue is whether that's enough BA to kill bacteria in the vial long term, correct?

Anything between 0.5% and 2% of BA is absolutely fine and will kill bacteria. I wouldn't go below 0.5%.

 

[bryan_usa]

Who is the vial guy?

 

[Deskoze38192]

Who is the vial guy?

From the QSC thread this week lol

 

[klokke23]

Anything between 0.5% and 2% of BA is absolutely fine and will kill bacteria. I wouldn't go below 0.5%.

Do you have anything to back this up? Because BA doesn't kill bacteria.

 

[TessaM]

Do you have anything to back this up? Because BA doesn't kill bacteria.

It mainly stops it from colonizing, you're right. Which is pretty much all that's necessary... But it can also kill some stuff. Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview (Section 2.1.2)

 

[HB_22]

Do you have anything to back this up? Because BA doesn't kill bacteria.

Youre right but it stops it growth and this will happen from as low as 0.5% to 2% and obviously even higher, but going any higher than 2% may not be healthy long term.

 

[klokke23]

Youre right but it stops it growth and this will happen from as low as 0.5% to 2% and obviously even higher, but going any higher than 2% may not be healthy long term.

You seem to say a lot without any backing

 

[OmL]

You seem to say a lot without any backing

Less arguing and more learning, please. He’s trying to help you.

 

[klokke23]

Less arguing and more learning, please. He’s trying to help you.

I don't need help. He's saying no less than 0.5 and no more than 2 because it's unhealthy long term. And I'm wondering where he's getting this info from.

 

[HB_22]

I don't need help. He's saying no less than 0.5 and no more than 2 because it's unhealthy long term. And I'm wondering where he's getting this info from.

Benzyl alcohol is commonly used as a preservative in multidose injectable pharmaceutical formulations. For this purpose, concentrations in the range of 0.5–2.0% are used and the whole amount of benzyl alcohol injected is generally very well tolerated. Concentrations of 0.9% are used in Bacteriostatic Sodium Chlorine (USP), which is often used in the management of critically ill patients to flush intravascular catheters after the addition of medications or the withdrawal of blood, and in Sterile Bacteriostatic Water for injection (USP), used to dilute or reconstitute medications for intravenous use.

Benzyl Alcohol - an overview | ScienceDirect Topics

www.sciencedirect.com

There is a study investigating bacterial growth in saline solutions with several different concentrations of Bac Water ranging from 0.1% to 2% that I currently can not find on my phone but I will post it later when I get back to my computer. That study found anything from 0.5% to 2% stopped bacterial growth and any higher concentrations were discontinued due to health risk considerations.

 

[klokke23]

Benzyl Alcohol - an overview | ScienceDirect Topics

www.sciencedirect.com

There is a study investigating bacterial growth in saline solutions with several different concentrations of Bac Water ranging from 0.1% to 2% that I currently can not find on my phone but I will post it later when I get back to my computer. That study found anything from 0.5% to 2% stopped bacterial growth and any higher concentrations were discontinued due to health risk considerations.

Thank you. I would like to see the study you're talking about. Because the quote you gave from Meyler's Side Effects of Drugs doesn't really say anything

 

[trtbuilder]

Thank you. I would like to see the study you're talking about. Because the quote you gave from Meyler's Side Effects of Drugs doesn't really say anything

Have you tried doing any research yourself, or do you just sit around waiting for everyone else to do the work for you?

 

[bryan_usa]

I think I found the article that @HB_22 referred to:

Benzyl Alcohol - an overview | ScienceDirect Topics

www.sciencedirect.com

Benzyl alcohol is commonly used as a preservative in multidose injectable pharmaceutical formulations. For this purpose, concentrations in the range of 0.5–2.0% are used and the whole amount of benzyl alcohol injected is generally very well tolerated. Concentrations of 0.9% are used in Bacteriostatic Sodium Chlorine (USP), which is often used in the management of critically ill patients to flush intravascular catheters after the addition of medications or the withdrawal of blood, and in Sterile Bacteriostatic Water for injection (USP), used to dilute or reconstitute medications for intravenous use. The content of benzyl alcohol in a lot of injectable pharmaceutical formulations needs to be considered carefully. The view still taken in many countries that the additives and excipients in medicines are trade secrets must be deplored. The duty to declare them is only imposed in some countries.


UPDATE: Argh! Just realized this is exactly the same write up that was already posted. Sorry.

 

[klokke23]

Have you tried doing any research yourself, or do you just sit around waiting for everyone else to do the work for you?

Yes I have. Thanks though

 

[trtbuilder]

Yes I have. Thanks though

Feel free to share it with us, since that's so important to you!

(he hasn't)