Cholesterol and rosuvastatin

gilmarpersonal

New Member
10+ Year Member
I'm using 5mg rosuvastatin day + 200mg Coq 10 but I'm feeling a lot of muscle and joint pain. My cholesterol before rosuvastatin was 280 now 150

Is there another alternative to Rosuvastatin?
 
Ezetimibe 5-10mg with 180mg bempidoic acid

Ezetimibe by itself is called Zetia.
Ezetimibe with bempidoic acid is called Nexlizet. I just get the two separate from an Indian pharmacy on this board.

If you have a cool doctor and great insurance the new king is Repatha. You won't find it at an overseas pharmacy
 
I'm using 5mg rosuvastatin day + 200mg Coq 10 but I'm feeling a lot of muscle and joint pain. My cholesterol before rosuvastatin was 280 now 150

Is there another alternative to Rosuvastatin?
You can change statin there are a few that are less strong then rosu but have less possible side effect plus add ezetimibe as been suggested above
 
Ezetimibe 5-10mg with 180mg bempidoic acid

Ezetimibe by itself is called Zetia.
Ezetimibe with bempidoic acid is called Nexlizet. I just get the two separate from an Indian pharmacy on this board.

If you have a cool doctor and great insurance the new king is Repatha. You won't find it at an overseas pharmacy
This ^^^
 
Rosuvastatin bothers me less than Atorvastatin.

Combined with ezetimbe and bempedoic acid, you will have to start lowering your dosage or spread them out because your cholesterol will get very low on that.
 
Rosuvastatin bothers me less than Atorvastatin.

Combined with ezetimbe and bempedoic acid, you will have to start lowering your dosage or spread them out because your cholesterol will get very low on that.
And if it gets low then what?
 
Speaking about Cholesterol getting too low, what about Triglycerides? Injectable carnitine 1x a day with 600mg puts them down to 50 for from 80.
 
I guess I’m the only one that enjoys rosuva

Nope. I think it's wonderful, particularly at lower doses.

You can change statin there are a few that are less strong

Pravastatin is a good choice for a lower incidence of side effects. Atorvastatin works for some when Rosuvastatin causes problems. Generally it's the inverse, however.

are you sure it’s from the statins?

My question, precisely.

Combined with ezetimbe and bempedoic acid, you will have to start lowering your dosage or spread them out because your cholesterol will get very low on that.

I've gone through the literature on this topic quite extensively. There's very little to indicate that LDL can get too low. There's a rare genetic disorder in which LDL is extremely low. The consensus tends to want to address that once it gets below 25mg/dL with the primary issue being absorption of certain vitamins.

Presently, mine is 17mg/dL and I've noticed no issues as a result.
 
Anyone have issues with libido on only 5mgs a day? Libido is so tricky because it's so sensitive to all kinds of life stressors. Though I feel like mine has been lower since starting Crestor. Bueller?
 
This is purely my experience, but I've mostly used OTC to keep my cholesterol down and it's worked very well, with no side effects to speak of. Although I have recently decided to add in low dosed rosuvastatin.

Previously I've been able to keep my LDL-C at around 100, with an APO-B from 50-70 with only 1000my citrus bergamot (500mg 2x a day, nutricost) and one serving of a fiber supplement a day (1 serving of Fiber+ by Project AD).

I like to think these numbers are pretty good but after listening to Peter Attia, I've decided to strive for lower APO-B numbers. I have a genetic risk factor for high LP(a), measuring as high as 212 and as low as 55. This has been dependent on diet phase, push vs cut or prep. I've noticed adding in 1200mg berberine (600mg 2x a day, nutricost or NOW), has always kept it on the lower side.

Peter Attia has the idea that with high LP(a) you should push APO-B as low as possible. After some more research I decided on a low dose rosuvastatin, 5mg a day, and will reasses with some blood work. So far no side effects to not.

My point, if you're having side effects you can probably lean into OTC supps and back off on the statin and you might have good results. There is also Bempadoic acid but I don't have any experience with it.
 
This is purely my experience, but I've mostly used OTC to keep my cholesterol down and it's worked very well, with no side effects to speak of. Although I have recently decided to add in low dosed rosuvastatin.

Previously I've been able to keep my LDL-C at around 100, with an APO-B from 50-70 with only 1000my citrus bergamot (500mg 2x a day, nutricost) and one serving of a fiber supplement a day (1 serving of Fiber+ by Project AD).

I like to think these numbers are pretty good but after listening to Peter Attia, I've decided to strive for lower APO-B numbers. I have a genetic risk factor for high LP(a), measuring as high as 212 and as low as 55. This has been dependent on diet phase, push vs cut or prep. I've noticed adding in 1200mg berberine (600mg 2x a day, nutricost or NOW), has always kept it on the lower side.

Peter Attia has the idea that with high LP(a) you should push APO-B as low as possible. After some more research I decided on a low dose rosuvastatin, 5mg a day, and will reasses with some blood work. So far no side effects to not.

My point, if you're having side effects you can probably lean into OTC supps and back off on the statin and you might have good results. There is also Bempadoic acid but I don't have any experience with it.
You can check my experiment until then

 
I wouldnt drop an statin completely they work as intended that’s for sure. Definitely helps mitigate one of the contributors to atherosclerosis, tho it is multifunctional.

Add in ezetimbe and try EOD dosing of your statin at the current MG, and/or ED dosing at 2.5mg. Or find a weaker statin of sorts, some good alternative were mentioned above.
 
I like to think these numbers are pretty good but after listening to Peter Attia, I've decided to strive for lower APO-B numbers. I have a genetic risk factor for high LP(a), measuring as high as 212 and as low as 55. This has been dependent on diet phase, push vs cut or prep. I've noticed adding in 1200mg berberine (600mg 2x a day, nutricost or NOW), has always kept it on the lower side.

ApoB in the range of 50-70mg/dL is quite good. Without any family history of ASCVD, I'd consider it fine.

The Lp(a) number is of concern, but I would see about backing that number up. Lp(a) shouldn't vary by much. I had one anomalous result, which at this point, I'm pretty sure was in error:

1739693704055.webp

That one outlier was what motivated me to get on Repatha.
 
ApoB in the range of 50-70mg/dL is quite good. Without any family history of ASCVD, I'd consider it fine.

The Lp(a) number is of concern, but I would see about backing that number up. Lp(a) shouldn't vary by much. I had one anomalous result, which at this point, I'm pretty sure was in error:

View attachment 316747

That one outlier was what motivated me to get on Repatha.

Made me re-check my latest bloodwork where i had Lipo A just 7nmol/l.
Given the fact that is mostly genetic, i'd assume it would be incredibly difficult to lower it right?
 
ApoB in the range of 50-70mg/dL is quite good. Without any family history of ASCVD, I'd consider it fine.

The Lp(a) number is of concern, but I would see about backing that number up. Lp(a) shouldn't vary by much. I had one anomalous result, which at this point, I'm pretty sure was in error:

View attachment 316747

That one outlier was what motivated me to get on Repatha.
I do have some very concerning family history unfortunately. I do bloodwork every 10-16 weeks or so and have for maybe three years. My lp(a) has varied by a wide margin depending on supplementation and diet. They say LP(a) is constant but I don't believe that.

For instance, times when I slack on my citrus bergamot and berberine supplementation, and increase my dietary fat intake, my LP(a) is significantly higher in the 200s. When I'm very dialed in and on top of my supplementation, it's much lower but still too high for my liking.
 

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