Dope Test Before Drug is Tested in Humans - benzothiazepines for endurance athletes

[Steroid News]

Dope Test Before Drug is Tested in Humans
[SIZE=-1]MIT Technology Review, MA [/SIZE]
[SIZE=-1]Now German scientists announce that they have developed a test for a class of compounds called benzothiazepines, which are being developed for the treatment of heart abnormalities and have been shown to boost endurance in mice. According to a press release from Drug Testing and Analysis, the journal publishing the research,[/SIZE]

[SIZE=-1]These compounds stabilize protein channels that would otherwise "leak" calcium from muscle cells during strenuous exercise. Calcium is needed for muscle contraction and this "leaking" effect weakens the contractions and is a causal factor in muscle fatigue.[/SIZE]
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[SIZE=-1]While the drugs have not yet been tested in humans, researchers say that they carry a high potential for abuse because they are easy to make. [/SIZE]

[SIZE=-1]"As soon as these drugs enter human clinical trials, there is a huge potential for them to be misused in sports. This preventive research lets us prepare before these compounds are officially launched," says Mario Thevis, Director of the Center for Preventive Doping Research at the German Sport University of Cologne, Germany, who led the research.[/SIZE]
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