MESO-Rx

Anabolic Steroids

E2 on Masteron

Biglittlejoe said:
My hematocrit has dropped into the normal range since I added 40 mg Telmisartan ED. Lipids were deranged last time I did labs, but I have since started retatrutide (currently 2.5 mg per week) so we will see if lipids have improved when I pull labs in a month.
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Telmisartan improve hct didnt know about it , Amazing.. did you take for bp or to lower your hct?
How many point did it lower?
 
Now that I am reviewing my lab results I see that my HCT had a very small decrease from 49.2 before telmisartan to 48.5 after. But I see my HCT had been as high as 53.6 before I lost 40 pounds a couple years ago. So it seems the telmisartan did not decrease my HCT that much.
 
The confusing part for me is my E2 was 130pg/ml at 2560 TT.

And when I added 480mg mast p to my 720mg test e my labs were:
  • Testosterone at 143.8 nmol/L = ~4148 ng/dL
  • Estradiol at 183 pmol/L = ~49.8 pg/mL
Then why I removed HCG and was transitioning to 750mg test/600mg mast e (pretty similar active mg plus I'm also increasing my test dose),
mast e didn't even fully build up (was on the first day of week 4) and my e2 was 25pg/ml.

Nothing proves it lowers serum levels but I see no other reason for my e2 to drop. I don't use an AI/Primo//EQ

I have 2 different blood tests with a higher e2 on less gear, and 2 with lower e2 on double the amount of gear. I rly want to run high mast during my cut but its very weird how it affects my e2.
 
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al3bod99 said:
The confusing part for me is my E2 was 130pg/ml at 2560 TT.

And when I added 480mg mast p to my 720mg test e my labs were:
  • Testosterone at 143.8 nmol/L = ~4148 ng/dL
  • Estradiol at 183 pmol/L = ~49.8 pg/mL
Then why I removed HCG and was transitioning to 750mg test/600mg mast e (pretty similar active mg plus I'm also increasing my test dose),
mast e didn't even fully build up (was on the first day of week 4) and my e2 was 25pg/ml.

Nothing proves it lowers serum levels but I see no other reason for my e2 to drop. I don't use an AI/Primo//EQ

I have 2 different blood tests with a higher e2 on less gear, and 2 with lower e2 on double the amount of gear. I rly want to run high mast during my cut but its very weird how it affects my e2.
Click to expand...
Well whats your chief complaint here? Mast lowering your e2 to much? Check it once the Mast fully saturates then make a determination , then you have "solid data"
 
Ateam2023 said:
Well whats your chief complaint here? Mast lowering your e2 to much? Check it once the Mast fully saturates then make a determination , then you have "solid data"
Click to expand...
Your increasing and decreasing but nothing is at"full saturation" you have to let everything level out and then pull bloods, micromanaging is a frustrating thing
 
Ateam2023 said:
Well whats your chief complaint here? Mast lowering your e2 to much? Check it once the Mast fully saturates then make a determination , then you have "solid data"
Click to expand...

Everyone says it doesn't lower serum levels but apparently that's what happening here, only using test/mast and it drops. Mast p when fully matured left me at 49.8pg/ml.

Thus when I doubled my TT while adding masteron, my e2 was dropped more than 60%.
 
al3bod99 said:
Everyone says it doesn't lower serum levels but apparently that's what happening here, only using test/mast and it drops. Mast p when fully matured left me at 49.8pg/ml.

Thus when I doubled my TT while adding masteron, my e2 was dropped more than 60%.
Click to expand...
i think 49 isnt a bad number tbh, thats where i feel best and function better , what are you after , as far as e2 "number" , are you chasing a certain number?
 
al3bod99 said:
Everyone says it doesn't lower serum levels but apparently that's what happening here, only using test/mast and it drops. Mast p when fully matured left me at 49.8pg/ml.

Thus when I doubled my TT while adding masteron, my e2 was dropped more than 60%.
Click to expand...
"everyone" says alot of things , this goes yt9 show ,"Everyone responds differently", its more and more becoming obvious, even in hgh use etc, And peoples data input is proof , for instance , my e2 doesn't really get effected by Mast use , it does help with 19 nor side effects from Npp though, "Everybody is different ",
 
Ateam2023 said:
"everyone" says alot of things , this goes yt9 show ,"Everyone responds differently", its more and more becoming obvious, even in hgh use etc, And peoples data input is proof , for instance , my e2 doesn't really get effected by Mast use , it does help with 19 nor side effects from Npp though, "Everybody is different ",
Click to expand...
I agree everyone is different. I was just confused as many people say that it doesn’t lower serum e2 period. When comparing or explaining someone’s lab results so I tool it a bit personal and wanted to deep dive into my results and wanted to prove that’s not the case dor everyone and it’s individual. 49pg is actually a great number for me.

One benefit is that I don’t need alot of eq and primo or ai to control my e2. (Money saver)

Downside is I would rly like to experiment with higher mast doses and since I aromatize little I’m afraid of trying eq since high doses can tank it. But then I would need to either up my test e or introduce a way to increase my serum e2 without tanking. And that’s seems a bit too complicated.
 
Worth r
bigdaddyandfriends said:
agree the most perfect/consistent compound to block E2 is exemestane - only one that works consistently in everyone, and doesn’t require constant dose modulation as you adjust aromatizing compounds
Click to expand...
Worth noting that exemestane is risky to overshoot (suicidal AI), and has a toll on lipid profile. In my ezperience, anasterozole microdosong 24h ad 72h poat injecrion was a safer choice.

Also worth noting that Masteron does not decrease plasma E2 levels, rather reduces its effects at receptor site. So, hard to dose based on e2 numbers.

Too much worth noting. I know.
 
thestruggle said:
Worth r

Worth noting that exemestane is risky to overshoot (suicidal AI), and has a toll on lipid profile. In my ezperience, anasterozole microdosong 24h ad 72h poat injecrion was a safer choice.

Also worth noting that Masteron does not decrease plasma E2 levels, rather reduces its effects at receptor site. So, hard to dose based on e2 numbers.

Too much worth noting. I know.
Click to expand...
True that with masteron. DHT and all derivates actually do that to some degree, masteron is the one that was brought to market for it. Interesting it's still on the USA formulary but no pharma masteron has existed for a long time. Primo is used for the same purpose in some parts of the world. But with SERMs, AIs, fulvestrant (an ER degrader), there is not much use for androgens in treating breast cancer.

Most literatue shows the opposite effect with AIs, with the same reduction in estrogen anastrozole is worse on lipids, as it is not as specific to aromatase and affects other enzymes too. But like everything else it's probably variable person to person. Anastrozole also lowers IGF-1 and tends to be harder on the hair, again allowing for same degree of estradiol reduction.

Overdosing on exemestane is definitely harder and longer to recover, but it takes a lot... even at 37.5mg/day the estradiol drop in men was about 70%. I've only crashed my e2 with anastrozole, but it rebounds/recovers quickly. The potency of it makes it problematic to correctly dose. The API/filler ratio in tablets is low, so splitting small tablets (particularly UGL) means any piece may have an even or very uneven split.

I just dose exemestane now prn, usually 6.25 or 12.5mg. If I start getting too emotional watching videos or listening to music, it's time to take it... seems to be keeping my E2/7a-me-E2 in a good range that way, with no high or low E2 symptoms getting the chance to develop.
 
bigdaddyandfriends said:
True that with masteron. DHT and all derivates actually do that to some degree, masteron is the one that was brought to market for it. Interesting it's still on the USA formulary but no pharma masteron has existed for a long time. Primo is used for the same purpose in some parts of the world. But with SERMs, AIs, fulvestrant (an ER degrader), there is not much use for androgens in treating breast cancer.

Most literatue shows the opposite effect with AIs, with the same reduction in estrogen anastrozole is worse on lipids, as it is not as specific to aromatase and affects other enzymes too. But like everything else it's probably variable person to person. Anastrozole also lowers IGF-1 and tends to be harder on the hair, again allowing for same degree of estradiol reduction.

Overdosing on exemestane is definitely harder and longer to recover, but it takes a lot... even at 37.5mg/day the estradiol drop in men was about 70%. I've only crashed my e2 with anastrozole, but it rebounds/recovers quickly. The potency of it makes it problematic to correctly dose. The API/filler ratio in tablets is low, so splitting small tablets (particularly UGL) means any piece may have an even or very uneven split.

I just dose exemestane now prn, usually 6.25 or 12.5mg. If I start getting too emotional watching videos or listening to music, it's time to take it... seems to be keeping my E2/7a-me-E2 in a good range that way, with no high or low E2 symptoms getting the chance to develop.
Click to expand...
Thank you for clarifying this for me. I didn't know that about Anastrazole. Is the negative effect on lipids and IGF-1 significant or dose dependant?
 
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