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Effects of Recombinant Human Growth Hormone Therapy in Obesity in Adults
[SIZE=-1]The Journal of Clinical Endocrinology & Metabolism Vol. 94, No. 1 130-137[/SIZE]
[SIZE=-1]Our metaanalysis suggests that rhGH therapy leads to decrease in visceral adiposity and increase in lean body mass as well as beneficial changes in lipid profile in obese adults, without inducing weight loss. Administration of rhGH was associated with increases in fasting plasma glucose and insulinemia. Because the rhGH doses used in many studies were supraphysiological, future studies of longer duration, using carefully titrated rhGH protocols, will be needed to fully establish the effects of rhGH therapy in obesity, including effects on cardiovascular morbidity and mortality....[/SIZE]
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[SIZE=-1]The Journal of Clinical Endocrinology & Metabolism Vol. 94, No. 1 130-137[/SIZE]
[SIZE=-1]Our metaanalysis suggests that rhGH therapy leads to decrease in visceral adiposity and increase in lean body mass as well as beneficial changes in lipid profile in obese adults, without inducing weight loss. Administration of rhGH was associated with increases in fasting plasma glucose and insulinemia. Because the rhGH doses used in many studies were supraphysiological, future studies of longer duration, using carefully titrated rhGH protocols, will be needed to fully establish the effects of rhGH therapy in obesity, including effects on cardiovascular morbidity and mortality....[/SIZE]
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