Grinding / blending a compound to make a smooth powder .

[Cashinked]

Does grinding a raw powder using a mortar or using a blender effect the structure of a compound , ie weaken it or destroy it ,

Let’s say you had a very course material and you wanted to cap it and you grinded or blended the material into a fine powder would it have any effect on the actual compound ?

 

[TheHaus88]

Does grinding a raw powder using a mortar or using a blender effect the structure of a compound , ie weaken it or destroy it ,

Let’s say you had a very course material and you wanted to cap it and you grinded or blended the material into a fine powder would it have any effect on the actual compound ?

It better not. I grind Anadrol and Anavar for oral suspension.

 

[hijoshiki]

Your not gonna effect the structure of the active compound.

The problem with the mortar and pestle for me has always been the microscopic bits of whatever the mortar and pestle are made of contaminating the raw. This is more of a concern when micronizing a compound for injected suspension where you sterilize, but aren't filtering which is bound to end up with microscopic unwanted debris.

As for oral there's no need in grinding the compound unless you're going from pill to powder and in that case you could just crush it and skip grinding it.

Keep in mind when you're filtering a compound its going through 0.2um pores, that's smaller than the human eye can see, you'd need a 50x objective under a microscope to see something that small.

 

[TheHaus88]

Your not gonna effect the structure of the active compound.

The problem with the mortar and pestle for me has always been the microscopic bits of whatever the mortar and pestle are made of contaminating the raw. This is more of a concern when micronizing a compound for injected suspension where you sterilize, but aren't filtering which is bound to end up with microscopic unwanted debris.

As for oral there's no need in grinding the compound unless you're going from pill to powder and in that case you could just crush it and skip grinding it.

Keep in mind when you're filtering a compound its going through 0.2um pores, that's smaller than the human eye can see, you'd need a 50x objective under a microscope to see something that small.

Bits of glass... I bought my mortar and pestle from a pharmacy equipment distributor, it's not decorative junk from Amazon so I'm hoping the Abombs(or was that Dbol) I use once a year are fine. Raw Anavar and either Dbol or Anadrol(I have a migraine I can't remember which is fine powder and which is coarse) is like salt and disolves better when it's ground up.

 

[Cashinked]

Your not gonna effect the structure of the active compound.

The problem with the mortar and pestle for me has always been the microscopic bits of whatever the mortar and pestle are made of contaminating the raw. This is more of a concern when micronizing a compound for injected suspension where you sterilize, but aren't filtering which is bound to end up with microscopic unwanted debris.

As for oral there's no need in grinding the compound unless you're going from pill to powder and in that case you could just crush it and skip grinding it.

Keep in mind when you're filtering a compound its going through 0.2um pores, that's smaller than the human eye can see, you'd need a 50x objective under a microscope to see something that small.

For a true homogeneous blend using a vmixer let’s say your base material plus excipient powders must be similar in size , so yes there is a need for grinding or blending if your raw Anavar or mk677 is very course it will never mix properly, that’s my point , I wanted to know exactly once you break down a compound. By a blender is there a point that it changes the structure if it’s done past a certain point over blending to a fine powder dust

 

[hijoshiki]

For a true homogeneous blend using a vmixer let’s say your base material plus excipient powders must be similar in size , so yes there is a need for grinding or blending if your raw Anavar or mk677 is very course it will never mix properly, that’s my point , I wanted to know exactly once you break down a compound. By a blender is there a point that it changes the structure if it’s done past a certain point over blending to a fine powder dust

You'd probably have to check with @janoshik he's the resident guru of chemistry.

I wouldn't think any active molecule of AAS would ever be larger than 5 nanometers molecular radius.

5 nanometers = 0.005 micrometers(microns)

So a typical 0.22um filter(used for sterilization) would let a 220 nanometer molecule though the pore. Which would offer no resistance to any compound getting through the filter at only 5nm.

This is just a rough estimate of what I think intuitively when I visualize a compound.

I'm sure Jano could go into more detail, but I would think grinding your compound wouldn't effect the potency, but wait until Jano chimes in.

 

[Sp2.0]

If it did I would think that orals tested by sources that have come through here would have been a lot worse. I remember a couple have said they used v mixers when @Mighty-mouse was raking them over the coals.

 

[Cashinked]

This is more in regards to oral powders for capping or pressing

 

[hangslo]

Grinding it won't hurt its structure at all. It is practically imperative with Var as a suspension or for capping as it is usually pretty coarse and not very homogenous in size.

 

[janoshik]

Blending or grinding gently won't affect literally any compound I've seen mentioned on this forum.