Hgh use

[dinfar1337]

What's the point of dragging Jano into this. I'm not calling his work into question lol.

He's a highly competent analytical chemist who runs a great lab providing a crucial service at an accessible price. That doesn't make him a biopharma guy any more than a great architect who designs hospitals is a brain surgeon.

I assume he's got better things to do than spend time reading about the pharmaceutical nuances of a particular compound as a hobby

Anyway. since the very technical references aren't exactly light reading, as a proxy I'll quote the plain english instructions from commercial rHGH.

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Omnitrope® (somatropin [rDNA origin])

“Once the diluent is added to the lyophilized powder, swirl gently; do not shake. Shaking may cause denaturation of the active ingredient.” 

Genotropin (Pfizer)

“Gently tip your pen from side to side to help dissolve the powder completely. Do not shake your pen, as this might stop the growth hormone working."

MiniQuick (Pfizer)

“Do not shake the GENOTROPIN MINIQUICK. Shaking may cause the growth hormone to not work as well."

Genotropin Pen (Pfizer)

“GENOTROPIN is a prescription product … Do not shake pen, as this might stop the medicine from working.” 

Saizen® (somatropin)

“To reconstitute SAIZEN, inject the diluent into the vial… swirl the vial with a GENTLE rotary motion until contents are dissolved completely. DO NOT SHAKE."

Humatrope Vial (Lilly)

“Do not shake. The reconstituted solution should be clear. Inspect visually for particulate matter and discoloration.” 

Humatrope Pen (Lilly)

“Be sure to gently invert the Pen up and down 10 times. DO NOT SHAKE. Then, let the Pen sit for at least three minutes.” 

----------------

To doubt these means multi-billion dollar pharma companies all caution against agitating rHGH because they just like to "say shit" based on a myth.

That none of their thousands of experts on staff would stand up and say, "You know, that's not correct" at any point in the last 30 years.

If this isn't sufficient, and you want I'll be happy to give you the heavier stuff that goes deep into air interface unfolding rHGH, but there's nothing straightforward about it and your eyes will glaze over.

tell your chatgpt that the vials is centrifuged. then it wont stress so much about degradation as the first answer that comes up to "hgh shaking".

 

[AlexDavis43]

I think its the longer chain which are more delicate and folded into 3 dim shapes, they even suggest using room temp bac water. They say vigorous mixing will even cause clumping more aggregates which make them less bio-available which make them harder absorb and more likely to trigger immune responses so I would be very careful as a precaution reconstituting with the hgh that comes not reconstituted.

There are at least 2 products that come already reconstituted.

How to incorporate that information with your interpretation? If GH is as sensitive as you suggest, it should be destroyed.

 

[undersc0re]

There are at least 2 products that come already reconstituted.

How to incorporate that information with your interpretation? If GH is as sensitive as you suggest, it should be destroyed.

Its most sensitive during reconstitution, once reconstituted just keep it out of light and refrigerated for the best possible end result I guess. I’ll stay out of this conversation now as you seem to have it under control I am far too uneducated to compete….sry.

 

[Ghoul]

tell your chatgpt that the vials is centrifuged. then it wont stress so much about degradation as the first answer that comes up to "hgh shaking".

LOL, ChatGPT told me AAS abuse induced cognitive impairment is the most likely reason someone would believe a bunch of irrelevant, only "theoretical" tests are being performed. That the scientists and experts at the FDA are all idiots looking at conditions that have no relevance to the real world. Accelerated degradation is a proven testing method for all pharmaceuticals, and directly related to lower amounts of the same stressor, causing proportionate damage. Whether it's temperature, light exposure, or agitation.

"Jano shook the crap out of a vial, and after performing a test that can't measure the damage that causes, determined shaking causes no damage."

For those in the back, HPLC can't distinguish between folded (active) and denatured/unfolded (inactive) rHGH. They both count as "pure",

The presence of unfolded rHGH in every manufacturer's unique process is why some brands have 2.7IU of activity per mg, and others have 3.1IU of activity per mg, despite both having nearly the same "purity". Unfolding more of it, by exposure to any cause of degradation, reduces potency without affecting purity,

This testing methodology is like sending a car into a brick wall at 50 km, and since all the metal, glass, and rubber is still there, declaring that proves no damage occurred.

For a decade a large proportion of experienced rHGH users have insisted the same dose of rHGH from pharma, or various UGL batches produce different results. Purity testing hasn't accounted for that difference. Pharma is "less pure" and should be inferior. Either all those people are crazy, and every 98% pure rHGH batch works identically, or there's an actual difference not seen by relying on "purity " testing alone. Which is it?

The people who do this for a living clearly understand this, and perform other tests in addition to purity to confirm the level of bioactivity, which varies from one rHGH product to another.

 

[stargab]

LOL, ChatGPT told me AAS abuse induced cognitive impairment is the most likely reason someone would believe a bunch of irrelevant, only "theoretical" tests are being performed. That the scientists and experts at the FDA are all idiots looking at conditions that have no relevance to the real world. Accelerated degradation is a proven testing method for all pharmaceuticals, and directly related to lower amounts of the same stressor, causing proportionate damage. Whether it's temperature, light exposure, or agitation.

"Jano shook the crap out of a vial, and after performing a test that can't measure the damage that causes, determined shaking causes no damage."

For those in the back, HPLC can't distinguish between folded (active) and denatured/unfolded (inactive) rHGH. They both count as "pure",

The presence of unfolded rHGH in every manufacturer's unique process is why some brands have 2.7IU of activity per mg, and others have 3.1IU of activity per mg, despite both having nearly the same "purity". Unfolding more of it, by exposure to any cause of degradation, reduces potency without affecting purity,

This testing methodology is like sending a car into a brick wall at 50 km, and since all the metal, glass, and rubber is still there, declaring that proves no damage occurred.

For a decade a large proportion of experienced rHGH users have insisted the same dose of rHGH from pharma, or various UGL batches produce different results. Purity testing hasn't accounted for that difference. Pharma is "less pure" and should be inferior. Either all those people are crazy, and every 98% pure rHGH batch works identically, or there's an actual difference not seen by relying on "purity " testing alone. Which is it?

The people who do this for a living clearly understand this, and perform other tests in addition to purity to confirm the level of bioactivity, which varies from one rHGH product to another.

This is post is the perfect reason why it’s difficult to take anything you say seriously.

You went from detailing a very specific scientific process and talking in absolute certainty’s and when someone asks you for sources you start making up a bunch of if/but/maybes.

 

[dinfar1337]

This is post is the perfect reason why it’s difficult to take anything you say seriously.

You went from detailing a very specific scientific process and talking in absolute certainty’s and when someone asks you for sources you start making up a bunch of if/but/maybes.

the if/but/maybes weren't even relevant to what i said. your vial is centrifuged. you would have to shake it 10x faster than jerking off speed to damage it. i mentioned this because he was so happy to talk about the degradation of the hgh from shaking. then he just answered me bunch of nonsense that wasnt relevant?

 

[TRTSCOUT]

@Ghoul and others....I am keeping all my lypholized HgH and peptides stored in a -40 non-defrost freezer...so stable temp, and dark.

Which if any do you think should not be stored in this freezer:
Please comment on HGH...

others if you have informed thoughts:
RETA
TIRZ
TESA
IPA
MOTS-C
BP157/TB500/GHKcu

 

[dinfar1337]

@Ghoul and others....I am keeping all my lypholized HgH and peptides stored in a -40 non-defrost freezer...so stable temp, and dark.

Which if any do you think should not be stored in this freezer:
Please comment on HGH...

others if you have informed thoughts:
RETA
TIRZ
TESA
IPA
MOTS-C
BP157/TB500/GHKcu

if you have bought 10 years of hgh use, surely keep all the hgh in -40 non defrost freezer. if u just have one a two years of storage just fucking keep it in the fridge lol