High AST ALT

[Eddie.]

This post got me curious. So I looked it up.

N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks) - PMC

To review the clinical usefulness of N-acetylcysteine (NAC) as treatment or adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic fibrosis, and chronic obstructive lung disease has been well documented, but there is ...

pmc.ncbi.nlm.nih.gov

“The bioavailability of oral NAC in humans is between 4 and 9.1% in one study [20] and between 6 and 10% in another [21]; thus, studies using less than 1200 mg per day may show no significant benefit.”

Do they even make NAC injections? Oral unless taken in insanely high doses might be a waste of time.

Well, shit lol. Firstly, i had no clue NAC can be administered other than orally and second, i believed that bioavailability was much much higher.

NAC helps with glutathione production and i know glutathione when used IV it's the best liver detox but orally it sucks, that's why most guys who want to avoid IV drips opt for NAC and not oral glutathione.

For the record, 2gr oral NAC made my pre blast γ-GT of 33 (without NAC yet) go down to 7 after blast, which included orals as well. So for me it definitely helps.

 

[Sgt.LincolnOsiris]

IME , word of advice, getready for "that junkie look" from doing iv route, unless your a seasoned pro, its hard not to mark yourself up with unsightly needle puncture marks, if you have tattoos on your arms (sleeves) then no need to worry about the junkie marks,,

Are track marks not cool anymore? Kidding of course. I’m just trying to figure out the best way to take it and if it’s possible without a drip. I’m pretty sure that IM and Subcutaneous are not options for NAC. I’m surprised there isn’t more information available on it for as much as people praise it:

 

[Photon]

Well, shit lol. Firstly, i had no clue NAC can be administered other than orally and second, i believed that bioavailability was much much higher.

NAC helps with glutathione production and i know glutathione when used IV it's the best liver detox but orally it sucks, that's why most guys who want to avoid IV drips opt for NAC and not oral glutathione.

For the record, 2gr oral NAC made my pre blast γ-GT of 33 (without NAC yet) go down to 7 after blast, which included orals as well. So for me it definitely helps.

Do you have any lab results for glutathione usage?

This post got me curious. So I looked it up.

N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks) - PMC

To review the clinical usefulness of N-acetylcysteine (NAC) as treatment or adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic fibrosis, and chronic obstructive lung disease has been well documented, but there is ...

pmc.ncbi.nlm.nih.gov

“The bioavailability of oral NAC in humans is between 4 and 9.1% in one study [20] and between 6 and 10% in another [21]; thus, studies using less than 1200 mg per day may show no significant benefit.”

Do they even make NAC injections? Oral unless taken in insanely high doses might be a waste of time.

Are track marks not cool anymore? Kidding of course. I’m just trying to figure out the best way to take it and if it’s possible without a drip. I’m pretty sure that IM and Subcutaneous are not options for NAC. I’m surprised there isn’t more information available on it for as much as people praise it:

NAC can be brewed at the same doses as carnitine (1g/ml). However I do not know if it's better when comparing on a mg/ml basis to glut. Glut 700mg+/ml vs NAC 1g/ml. Probably easier to brew NAC too as it's less finicky about ph.

Glut has a short half life and clears rapidly (which is why i pin subq), whereas NAC has a longer h/l and converts to glut (but at what rate?).

There is oral glut with higher availability, but that is very expensive. I think its S-glut or something, never bothered to look it up.

 

[Nidus]

Do you have any lab results for glutathione usage?




NAC can be brewed at the same doses as carnitine (1g/ml). However I do not know if it's better when comparing on a mg/ml basis to glut. Glut 700mg+/ml vs NAC 1g/ml. Probably easier to brew NAC too as it's less finicky about ph.

Glut has a short half life and clears rapidly (which is why i pin subq), whereas NAC has a longer h/l and converts to glut (but at what rate?).

There is oral glut with higher availability, but that is very expensive. I think its S-glut or something, never bothered to look it up.

4x500mg Glutathione per week moved my AST, ALT and GGT from 22, 25, 12 to 8, 10, 10.

 

[Eddie.]

Do you have any lab results for glutathione usage?

I have never used glutathione.

 

[Grey Spartan]

Well not sure what happened but after taking a week off the gym and basically stopping all supplements

Through my experiments, I found if I take any supplements 24 hours before blood work, my ALT and AST will be elevated.

 

[trtchin]

Last post on this just in case it could help anyone in the future. Got an abdominal ultrasound today and the radiologist checked all my organs, liver, kidneys, gallbladder, ducts, pancreas even prostate.

All perfect with no explanation for the elevated GGT reading. He guessed it was from something I ate or some supplements I took. Weird but I feel a lot better now.

 

[Liter O' Test]

There are so many research side quests sparked by GLPs researches in all the relevant areas are going to be maxed out for decades.

Consider improved neuron insulin sensitivity, because GLPs cross the blood brain barrier. It means neurons are more responsive, leading to improved cognition and memory formation. Mood improvement from enhanced dopamine function. Reduced inflammation means slower age related degeneration of the brain.

It's endless. The real trick is to find a dose that doesn't excessively reduce appetite while providing the other benefits.

Reta is leading the way on this. We have members using it primarily for insulin sensitivity, and it seems pretty easy to find a dose that accomplishes that without killing the ability to eat.

Semi related,

any new thoughts on GLPs and dopamine?

I'll add this regarding the psychological impact. Initially it was proposed a suicide warning be put on the box of Ozempic/Wegovy, but research showed less of a risk than the general population, not more.

Yet there's still conflicting data showing increased and decreased rates of depression. I suspect what's happening is that the sudden loss of food as a reward, from the appetite suppression, occurs before the brain adjusts to no longer need the dopamine hit. So you can't eat, but still feel one of the primary drivers that people experienced causing them to eat. That is, eating relieved depression with a dopamine hit.

Then in time, the brain adjusts, the "addiction" lifts, and along with all the other benefits of weight loss, lessened inflammation, greater mobility, and improved satiety in many things, mood improves, depression lifts, and suicide risk drops below the non-GLP using population.

At least that's what the data seems to suggest. An initial increase in depression(for some who were already depressed and medicating with food), then as time goes on, a steady improvement.

 

[wp_375]

Well, shit lol. Firstly, i had no clue NAC can be administered other than orally and second, i believed that bioavailability was much much higher.

NAC helps with glutathione production and i know glutathione when used IV it's the best liver detox but orally it sucks, that's why most guys who want to avoid IV drips opt for NAC and not oral glutathione.

For the record, 2gr oral NAC made my pre blast γ-GT of 33 (without NAC yet) go down to 7 after blast, which included orals as well. So for me it definitely helps.

What duration did you run 2g for?

 

[Ghoul]

Semi related,

any new thoughts on GLPs and dopamine?

It's pretty clear at this point that dopamine tone is reduced with GLPs, blunting the "reward" of food (and other addictive substances and behaviors). This can cause the temporary "downer" effects some people experience until the brain rebalances.

There are folks in the biohacking community using low dose selegeline, which inhibits MAO-B, the enzyme that breaks down dopamine, to increase dopamine levels, offsetting the fatigue, anhedonia, and loss of motivation when initiating or titrating GLPs.

 

[Eddie.]

What duration did you run 2g for?

It was 7-8 weeks if i remember correct. I'll probably run 1gr year round from now on, I'm already 2 months on that dose.

Tudca is good too but it's hella expensive to run year round.

 

[dinfar1337]

44M on a TRT dose of 150 mg / week M/W/F. Been on TRT for 6+ months.

One of my nips was a bit sore so I wanted to test my E2. Stopped on the way to work this morning. I also added a liver test as I haven't tested since being on TRT.

I lifted the day prior, took all my regular supplements the day prior lunch and dinner time. The morning before my test i did some LISS on my bike for 30 mins with 7.5 mg yohimbine.

Drank about a liter of water before my test and had some black coffee.

AST - 45 (ref 5-34)
ALT - 223 (ref <55)
GGT - 66 (ref 12-64)

I haven't had alcohol for more than a week before the test and im not a big drinker. My last test in 2023 was all normal.

I assume this result is skewed by my regular supplements, and/or the morning exercise and/or the yohimbine? Just want to make sure this isn't a huge concern. Will get a follow up in 2 weeks.

i once had asat alat at both at 300+

i have done tren + accutane before but never had any issues with my blood test before honestly. adding in clenbuterol my asat alat were crazy high.

now im back on accutane and a little bit of tren and we are good.

for some reason i think fat burners increase alat/asat insanely high. i thought it was the tren or accutane last time but im doing 5x my last accutane dosage with no issues. try to drop the yohimbe for a week and see if its down