High E2

[buck]

Been having E2 issues for a going on a year. Worked out for 50 years. Mostly weights but aerobics fairly often as well. Eat healthy all my life. Probably take way more OTC supps then i need but always have and nothing new there. Been on Dr. prescribed TRT for about 24 years, doing 15mg/day for a few years now. Keeps me about 720-820 range. For the last 10 years my cycles have been a whooping 200-300mg/week when i do 1. Usually test or test and primo that i know is good. E2 levels when i started 24 years ago were 9-14. Never had any real issues controlling E2 even on cycles. over the last 20 years it has risen to the 30's or a little higher using .5mg a week at most of Anastrozole. Then hit a big jump a year ago. On TRT dose now with .5 mg 3x week of anastrozole the E2 is still high. Just got my last labs in and it showed E2 was 65 and T was 730. Everything else looked good as usual other than the A/G ratio which is always a little high. As all the studies i have seen show long term that E2 over 40 things are less healthy long term. I am looking to keep it down. Any input or experience with something like this?

 

[caffaddicted]

if you’re on anastrozol and still have high e2
You gotta go see an endocrinologist

I would suggest to come off trt so your hormones auto regulate but at your age I would def see a profesional

 

[buck]

if you’re on anastrozol and still have high e2
You gotta go see an endocrinologist

I would suggest to come off trt so your hormones auto regulate but at your age I would def see a profesional

Thanks you. I went on TRT 24 years ago as my T levels were low and giving me negative consequence this was before i ever did any cycles, And as i wrote i have been seeing a professional for all those years. So i don't see how my hormone levels could auto regulate in any direction but even farther down then they were 24 years ago. My TRT Dr. is not an endo. But the last endo i saw many years ago told me there was no reason to track E2 levels as they were not important. So my experience with endo's is not inspiring. Have you had good luck with endo's?

 

[Dickwang]

On TRT dose now with .5 mg 3x week of anastrozole the E2 is still high. Just got my last labs in and it showed E2 was 65 and T was 730. Everything else looked good as usual other than the A/G ratio which is always a little high.

I know my e2 gets too high when I see or hear someone chewing with their mouth open next to me… I say I’ll be right back… then I go into the other room and take a deep breath… before returning to be with them….Or during sex I can last forever but my dick is around 70% hard….

I take .5 adex when that happens usually and it gets me back to normal within 24-48 hours… .

As the other guy said 1.5 mg of adex should have your e2 well within range even if you are taking 400-500mg a week…

Have you ever got your adex tested to make sure it’s dosed properly? Could be severely underdosed….

Or since you get older and e2 naturally gets higher and stronger (I think) could be time to try aromasin instead… maybe you need an irreversible binding ai at this point….

 

[buck]

I know my e2 gets too high when I see or hear someone chewing with their mouth open next to me… I say I’ll be right back… then I go into the other room and take a deep breath… before returning to be with them….Or during sex I can last forever but my dick is around 70% hard….

I take .5 adex when that happens usually and it gets me back to normal within 24-48 hours… .

As the other guy said 1.5 mg of adex should have your e2 well within range even if you are taking 400-500mg a week…

Have you ever got your adex tested to make sure it’s dosed properly? Could be severely underdosed….

Or since you get older and e2 naturally gets higher and stronger (I think) could be time to try aromasin instead… maybe you need an irreversible binding ai at this point….

Thanks for the reply.
As i stated 1.5/week is what i take of arimidex and mine is still high. If things worked as they should i would not have questions. Or spent many hours online searching out answers.
As my cholesterol has always been lower then i like I am concerned about aromasin lowering it even more as that is one of the side effects. And low cholesterol can shorten life spans more then high does from the studie i have seen.
My arimidex is prescription from a US pharmacy. Same all my T that i use for TRT

 

[Dickwang]

Thanks for the reply.
As i stated 1.5/week is what i take of arimidex and mine is still high. If things worked as they should i would not have questions. Or spent many hours online searching out answers.
As my cholesterol has always been lower then i like I am concerned about aromasin lowering it even more as that is one of the side effects. And low cholesterol can shorten life spans more then high does from the studie i have seen.
My arimidex is prescription from a US pharmacy. Same all my T that i use for TRT

My only other suggestion here if you want to stick with arimidex…I’m not a doctor(obviously)… these are just the steps I would take..

Lower your test dose… or switch to ed/eod dosing for test injections…

 

[buck]

My only other suggestion here if you want to stick with arimidex…I’m not a doctor(obviously)… these are just the steps I would take..

Lower your test dose… or switch to ed/eod dosing for test injections…

My T dose is 15mg/day. = 105mg a week. So i guess i would need to cut it in half or lower to get the E2 down that way.

 

[Dickwang]

My T dose is 15mg/day. = 105mg a week. So i guess i would need to cut it in half or lower to get the E2 down that way.

If adex 1.5mg isn’t working for 105mg a week. Is that the dose you’re doing ?

Then something is seriously wrong with your adex or hormones….

Try 2mg a week… but that just seems like a crazy amount of Ai for 105mg…

 

[buck]

If adex 1.5mg isn’t working for 105mg a week. Is that the dose you’re doing ?

Then something is seriously wrong with your adex or hormones….

Try 2mg a week… but that just seems like a crazy amount of Ai for 105mg…

Yes those are the doses. Which put my T level around 800/daily and E2 80-100.
I know something is wrong with my hormones. aromatase enzyme, i am guessing, That is why i posted this question here and other places. I did not figure i would find an answer here as it is unusual. 99.9% of issues i can find a solution to online quickly most of the time without asking questions. But i am always open to hearing what may be causing an issue. I understand throwing more drugs or manipulating them, at a problem but i was hoping to find what may be causing the issue.

 

[Dickwang]

Yes those are the doses. Which put my T level around 800/daily and E2 80-100.
I know something is wrong with my hormones. aromatase enzyme, i am guessing, That is why i posted this question here and other places. I did not figure i would find an answer here as it is unusual. 99.9% of issues i can find a solution to online quickly most of the time without asking questions. But i am always open to hearing what may be causing an issue. I understand throwing more drugs or manipulating them, at a problem but i was hoping to find what may be causing the issue.

Drop the test dose, up the ai dose, or switch to aromasin… I think those are the only options here my friend…

 

[buck]

Drop the test dose, up the ai dose, or switch to aromasin… I think those are the only options here my friend…

Thanks. I will probably keep looking at to what caused the change. May go to an endo to see if he has any ideas. Worse case i will look at combing 2 AI's

 

[Dickwang]

combing 2 AI's

Not sure that would be the best idea my friend ….

 

[buck]

Not sure that would be the best idea my friend ….

Please explain why not? What studies have you seen about negative consequences.

 

[caffaddicted]

My T dose is 15mg/day. = 105mg a week. So i guess i would need to cut it in half or lower to get the E2 down that way.

cutting your dose in half
will put your total testosterone in the mid low end how often do you pin?
do you consume any type of soy product?
do you supplement with zinc?
my endo asked me this questions
i had a similar problem

 

[Jin23]

What a shit show of bad advice this thread has been. Op even got advised to go off of medically supervised trt, on which he has been on for 24 years. Hat's down to you @buck for keeping your cool and actually talking politely to these people.

It seems like your arometase expression is increasing. I don't have any reall advice besides pointing you to a different forum which revolves around trt (excelmale) and not steroids use.

Have you gotten fatter? Have your increased hcg use? Maybe your shbg droped and you have more free T and thus more E2. Maybe you could try and switch to a suicide ai ... Using dutasteride maybe? Or maybe some other supp of which you mentioned that you're taking a lot off is modulating arometase expression or lowering shbg.

Needless to say, if the free androgen index is within normal paramaters, e2 should fall in range. Where is your free t at? Crp? Iron, cbc? Got any blood work to share?

 

[buck]

cutting your dose in half
will put your total testosterone in the mid low end how often do you pin?
do you consume any type of soy product?
do you supplement with zinc?
my endo asked me this questions
i had a similar problem

Cutting my dose in half would seem to lower the health benifits i may get from TRT. As that i one reason i started TRT. If i have to choose between lower T benifits or taking more AI i will choose more AI
As i posted i micro dose for the last few years. That usually causes les aromatization from my reading Did weekly injections for 15 years before that.
Quit eating soy products over 30 years ago as i didn't want to add in more phytoestrogens
Yes zinc and copper
So was your endo not be able to figure out why your E2 levels went up?

 

[buck]

What a shit show of bad advice this thread has been. Op even got advised to go off of medically supervised trt, on which he has been on for 24 years. Hat's down to you @buck for keeping your cool and actually talking politely to these people.

It seems like your arometase expression is increasing. I don't have any reall advice besides pointing you to a different forum which revolves around trt (excelmale) and not steroids use.

Have you gotten fatter? Have your increased hcg use? Maybe your shbg droped and you have more free T and thus more E2. Maybe you could try and switch to a suicide ai ... Using dutasteride maybe? Or maybe some other supp of which you mentioned that you're taking a lot off is modulating arometase expression or lowering shbg.

Needless to say, if the free androgen index is within normal paramaters, e2 should fall in range. Where is your free t at? Crp? Iron, cbc? Got any blood work to share?

I understand what asking a question on a forum is like and it is always my last resort after spending many hours searching online reliable medical sources for the question i have.Not counting decades of reading about health, nutrition, endocrinology, etc. I usually never get answers to my questions as i already know how to pick low hanging fruit.
Most all my blood work would be in a healthy range and i am not talking about normal range which i don't find to always be optimal. CRP is usually in the lower 30 percentile for a few decades for example
A 30 year old would be happy to have my 64 year old prostate gland. Although for decades my PSA was .4 now it has rocketed up to .7.
I assume my aromatase enzyme has increased or is some how working faster but have found no reason for that. The only thing is that getting older can suck. But ya deal with it and move on.
I have not been over to excelmale for some time but may have to head that way.

 

[warlockandrogen]

the gut detoxes estrogens and if it cant do its job E2 will accumulate. Maybe any recent dietary changes?

 

[buck]

the gut detoxes estrogens and if it cant do its job E2 will accumulate. Maybe any recent dietary changes?

I have never read anything about the gut detoxing estrogen. Where did you read this? Testosterone is made in the body or injected into it and never enters the gut. Once estrogen is in the blood stream how would the gut do that? The liver breaks it down and removes it from the blood stream.

 

[warlockandrogen]

I have never read anything about the gut detoxing estrogen. Where did you read this? Testosterone is made in the body or injected into it and never enters the gut. Once estrogen is in the blood stream how would the gut do that? The liver breaks it down and removes it from the blood stream.

Once estrogen is prepared and ready to be excreted, it enters the kidney’s for urination or leaves the liver via bile and makes its way into the colon to be excreted by stool.

A collection of gut bacteria called the estrobolome are capable of metabolising estrogen. They do this by producing an enzyme called beta (β)-glucuronidase, which takes the estrogen ready for excretion and sends it back into circulation. This leads to higher levels of estrogen in the body creating an estrogen dominance hormone imbalance. Calcium D-glucarate inhibits the activity of β-glucuronidase and can be found in supplement form. Eating a diet rich in fiber and fermented foods will support a healthy gut microbiome.