The book chapter you're refering to describes Leydig cell-derived CRH (in animal models). Leydig cell-derived CRH plays no endocrine role and will not have any influence on your HPA. (The book chapter itself even solely describes its paracrine role, too.)
How has your low cortisol been determined and has any diagnosis been made?
Yes, low cortisol i take adrenal cortex 3 to 4 times a day, but last few days i have felt better. If i lower my trt dosage to the 110mg a week range i do very well actually extremely well ,but when i get to the 150mg a week dosages it drians me.
I bumped back up to 150mg plus the hcg, so far so good....werid. so thats why i was wondering if theres a range woth the hcg. Etc
E2 is always checked always on point etc
I do extensive blood work, my doc lets me add anything i want.
Im also a night worker, for 4 years so my circadian rhythm is messed up.
Its hard to diognose low cortisol when someone is on nights, for 4 years , All saliva tests are inaccurate. I would need to be on days for a good length of time to get a good reading, so im not wasting anymore money on them, i no whats wrong, i just dont know if hcg will fix it. Theres really no explanation for feeling strength at low dose trt, and worse on a higher dosage.
iv been at this awhile, i do more blood work then most every 2.5 months, low blood cortisol confirms it when both am and pm are low, blood cortisol is bound and unbound, so when there both low , then its low. If they came back high, or at least 1 high then it is debatable, symptoms match the blood work, also my ft4 has always pooled and not converted to ft3 properly, basically no matter how much t4 i take it stays the same, due to low cortisol, but the adrenal cortex has helped me to get my thyroid hormones into the cells. When I lower my trt i also have to adjust thyroid hormones, so figure that one out lol.
My thyroid is under control now for the most part ft3 is top of reference range, but ft4 still a bit behind, if i can get that extra bump in cortisol from the hcg opening up old pathwas ,then id be happy.
Changes though when i excercise ,i feel fantastic, my cortisol comes back great am and pm, as i believe I stimulate my acth and then i get alot of circulating cortisol, but if i stop for a bit its pretty much like it runs out.
Only on first week of hcg, ill give it a few weeks and see of it works. Iv read other fourms where some say it changed them and other say it wasn't enough.
I also take prescription pregnenolone, and my last labs came back over the reference range so ill tinker with that as well.
Was just curious what other's thought about maybe starting to test hcg on blood work.
