How gear like primo and mast regulate e2

[Isosceles Gangster]

I'm just curious the science behind this, how certain gear controls or reduces estro? I have never run anything like primo or mast, I always run "wet" compounds with the exception being tren in the past.

I would really like to drop the ai on my current high test only cycle and was considering primo for estrogen control. I'm trying to stay the fuck away from 19nors and most orals these days.

Might be dumb question but it's a gap in my knowledge banks.

 

[Spaceman Spiff]

Effect of drostanolone propionate on the binding of oestradiol and dihydrotestosterone by normal and malignant target tissues

The influence of drostanolone propionate, an anticancer agent, was tested on the binding of 17 β-oestradiol and dihydrotestosterone to specific recept…

www.sciencedirect.com

 

[FunkOdyssey]

Effect of drostanolone propionate on the binding of oestradiol and dihydrotestosterone by normal and malignant target tissues

The influence of drostanolone propionate, an anticancer agent, was tested on the binding of 17 β-oestradiol and dihydrotestosterone to specific recept…

www.sciencedirect.com

Full text: https://www.wellesu.com/10.1016/0014-2964(77)90193-1

 

[Isosceles Gangster]

It competitively inhibits the aromatase enzyme.. is what I take from that.

Thanks

 

[UncleBuns]

It competitively inhibits the aromatase enzyme.. is what I take from that.

Thanks

Not sure where you came up with that, Mast does not effect aromatase. It modulates and inhibits Estrogens effect in some tissues. It does not lower estrogen levels. Primo on the other hand can lower Estrogen in some guys but this effect varies significantly person to person.

 

[egruberman]

Primo on the other hand can lower Estrogen in some guys but this effect varies significantly person to person.

My understanding of it is that one of the metabolites of primo is an aromatase inhibitor and as such the resultant AI effect is going to be dependent on how each individual metabolizes it.