Increased PSA value

[amindzeye]

I got blood work done... Most things are in range. I noticed that my PSA Total has increased from .7 to 2.03. It's still within range, but am wondering if I should blast again. I've had it checked multiple times, always came back around .6-.7. The last reading of .7 was after a cycle with mast, var, and anadrol. They didn't affect psa at all. I finished a blast with those same dosages again, with tren and HGH included, but now it has raised.

 

[Evom1]

That big of an increase would be alarming, I'd want to consult with a physician

 

[Apple-ice]

Have you consulted with a doctor on the data that you have in medical analyzes?

 

[Type-IIx]

RhGH can increase PSA, because PSA is an IGFBP-3 protease, and GH is the primary stimulator of IGFBP-3.

This is not to say that it rules out pathology/tumorigenesis/cancer; consider that growth hormone-releasing hormone antagonists are effective treatments to shrink enlarged prostates.

 

[amindzeye]

This is not to say that it rules out pathology/tumorigenesis/cancer; consider that growth hormone-releasing hormone antagonists are effective treatments to shrink enlarged prostates.

Can you elaborate on this? Meaning I should get ahold of Pegvisomant?

 

[Type-IIx]

Can you elaborate on this? Meaning I should get ahold of Pegvisomant?

Oh no, just a caution that we cannot exclude the possibility of continuing increases to PSA being something more pernicious. If I were still within normal range, I'd be chalking it up for now myself to a natural byproduct of increased IGFBP-3 by rhGH.

 

[amindzeye]

Oh no, just a caution that we cannot exclude the possibility of continuing increases to PSA being something more pernicious. If I were still within normal range, I'd be chalking it up for now myself to a natural byproduct of increased IGFBP-3 by rhGH.

Thanks for your input. It put me at ease. If this were your scenario, would you consider continued use of rhGH, or chalk it up to a compound that doesn't agree with your biological system?

 

[Type-IIx]

Thanks for your input. It put me at ease. If this were your scenario, would you consider continued use of rhGH, or chalk it up to a compound that doesn't agree with your biological system?

I'd continue but keep an eye on PSA.

 

[Mac11wildcat]

This is an issue near and dear to me having lost my father-in-law to prostate cancer. I’d be consulting with a doctor and considering another test. Some things can artificially raise PSA, but it’s the single marker where “it’s in range” isn’t adequate if there is any trend upward.

 

[B Ware]

Thanks for your input. It put me at ease. If this were your scenario, would you consider continued use of rhGH, or chalk it up to a compound that doesn't agree with your biological system?

I would not be “at ease” and would not be “chalking it up”. Yes, you are still with in range and everything may be hunky-dory but that’s is a significant increase and I would be concerned.

I’m on doctor’s prescribed trt for this very reason as prostrate cancer runs in my family and I need/want to be monitored. I’ve been taking hgh for 2+ years and I have not seen any increase in my psa from taking hgh myself.

Definitely consult a doctor

 

[Type-IIx]

This is an issue near and dear to me having lost my father-in-law to prostate cancer. I’d be consulting with a doctor and considering another test. Some things can artificially raise PSA, but it’s the single marker where “it’s in range” isn’t adequate if there is any trend upward.

I would not be “at ease” and would not be “chalking it up”. Yes, you are still with in range and everything may be hunky-dory but that’s is a significant increase and I would be concerned.

I’m on doctor’s prescribed trt for this very reason as prostrate cancer runs in my family and I need/want to be monitored. I’ve been taking hgh for 2+ years and I have not seen any increase in my psa from taking hgh myself.

Definitely consult a doctor

Sure, family history changes the risk.

 

[amindzeye]

Sure, family history changes the risk.

I have no known family incidents of Prostate Cancer.

 

[Type-IIx]

I have no known family incidents of Prostate Cancer.

I wouldn't be particularly worried, to me this would just be something to keep an eye on (PSA). I'd reduce my testosterone dose and introduce a 5AR antagonist (dutasteride, finasteride) prophylactically if anything. I'm pretty low in trait anxiety and think that self-ordered bloodwork tends to raise anxiety unnecessarily in general.

 

[Apple-ice]

I would not be “at ease” and would not be “chalking it up”. Yes, you are still with in range and everything may be hunky-dory but that’s is a significant increase and I would be concerned.

I’m on doctor’s prescribed trt for this very reason as prostrate cancer runs in my family and I need/want to be monitored. I’ve been taking hgh for 2+ years and I have not seen any increase in my psa from taking hgh myself.

Definitely consult a doctor

I have been actively undergoing cancer screening since the age of 20. My relatives have something from the side of the pope, that from the side of the mother. One way or another, there were deaths associated with cancer.

 

[BBC3]

Just my two cents and having a father and grandad both having issues and gone. (I started TRT as a remedy for that but also did not get vasectomies' like they did). So I am kind of a super-Guinea pig....

Running testosterone for 17 years now and currently under the direction of a urologist. As much as 200+ per week finally got me up from 0.7 to 0.9 at just over 50 years old. He stated thats the PSA of some teenagers and no sweat. I have backed down to 150/week now...

But consider this. PSA or PROSTATE SPECIFIC ANTIGEN is a simple notification that your prostate has sustained some kind of physical "Insult". Be it eating too much corn, to holding turds too long as a hobby, to having your wife jam her hand up your ass/ or just simple OVERJAK if you are one of those guys that can hit it 6+times a day. (I actually knew a guy that jacked it 8 times a day all summa long and he wound up with PC having to have it removed at about 40 years old).. . ALL OF THESE WILL RAISE PSA THRU THE ROOF. So its about physical aggravation of the prostate ON THE PSA TEST, and then possible long term damage depending.. Which is why you can ONLY RELY on the touch of a well trained and experienced urologist doing a finger check to be sure. Don't shy away from it and demand it if he does not insist. AND DON'T WAST YOU TIME ON A FAMILY OR GENERAL PRACTICIONER... He wouldn't know a low grade lump on your prostate from a piece of corn...!!! Of course second opinions do not hurt. You have to be sure the experience of the docs you see... MANY Prostate cancers evolve slowly and therefore DO NOT sound the "PSA Alarm".. Hence the need for the finger check...

And by the way if you review the footage they were big on the fact that a PSA test is not enough (back around 2015), and stated you need a finger to be sure has gone BYE BYE as a trending idiology. They don't even care anymore if you get it. The medical/ins industry has GONE CRAZY... Part of Agenda 21. Don't wind up "Watchful waiting"...

Also be careful the foods you eat. A health an wellness nut I used to know 30 years ago told me peanuts did it. No made no sense. But it turns out that one of the primary culprits in prostate cancer is CADMIUM... If your peanuts happened to be grown in dirt high in this heavy metal it would cause big problems. And my ancestors ate a SHIT TON of peanuts. Part of me wants to send some Jiff off for testing. But the other is scared to know...

 

[amindzeye]

I'm just going to wait a month and re test. I'm guessing if it's nothing serious, the PSA value should lower...

 

[amindzeye]

I'm just going to wait a month and re test. I'm guessing if it's nothing serious, the PSA value should lower...

@Type-IIx am I right on this assessment? I stopped the HGH use a week before the original test, so by the time I re-test, exogenous HGH would have ceased a month earlier... This would be enough time for the PSA value to lower if HGH was the reason the value almost tripled?

 

[Type-IIx]

@Type-IIx am I right on this assessment? I stopped the HGH use a week before the original test, so by the time I re-test, exogenous HGH would have ceased a month earlier... This would be enough time for the PSA value to lower if HGH was the reason the value almost tripled?

The time-course of changes to PSA (an IGFBP-3 protease) as a function of rhGH dose is unknown, but is almost certainly related to serum IGF-I pharmacokinetics. These peak at 6 - 8 weeks at a constant dose. After 12 weeks of rhGH at a constant dose, serum IGF-I returns to base-line after +12 weeks (+84 days), i.e., time on = time off.

Note that "almost tripling" doesn't confer significance in itself, if still within the normal healthy range, and if the trend over at least 30 samples (30 bloodwork results that are representative of testosterone administration) has been virtually zero change.

 

[amindzeye]

Note that "almost tripling" doesn't confer significance in itself, if still within the normal healthy range, and if the trend over at least 30 samples (30 bloodwork results that are representative of testosterone administration) has been virtually zero change.


I have around 5 previous samples.

 

[Mac11wildcat]

Note that "almost tripling" doesn't confer significance in itself, if still within the normal healthy range, and if the trend over at least 30 samples (30 bloodwork results that are representative of testosterone administration) has been virtually zero change.


I have around 5 previous samples.

Two results isn’t a trend, but having 20 results prior to a trend doesn’t make a trend or a trend. As I said, many things can cause an artificially high result. But 3 in a row ascending would have me concerned.