Is test test?

[Explore]

From anecdotal evidence different esters have different pharmacokinetics - more than just half-life.

I found this A study on 3 different testosterone esters, short, medium and long esters

Currently available testosterone (T) preparations differ substantially in their pharmacokinetic profile that might influence their androgenic properties in terms of suppression of the gonadal axis, effects on anabolic parameters, lipid metabolism, and erythropoiesis. The present work was undertaken to determine the physiological effects of three T preparations with different serum kinetics. Twenty adult male cynomolgus monkeys (Macaca fascicularis) were randomly assigned to receive treatment for 28 weeks with either T enanthate (TE) every 4 weeks, T buciclate (TB) every 7 weeks, or T undecanoate (TU) every 10 weeks or remaining untreated (controls). Each injection delivered 20 mg pure T per kilogram body weight. Pharmacokinetic profiles demonstrated higher peak levels of T for TE-treated animals; serum half-lives were longer for TU or TB. Estradiol levels (area under the curve) were significantly higher in TB vs TU or TE. All T regimens suppressed serum luteinizing hormone bioactivity and testicular volumes declined (all P <.001 vs controls). Sperm counts were markedly lowered in all animals but least in TE (P <.01 vs TB or TU). During recovery phase, return to normal for all three parameters occurred significantly earlier in TE-treated animals, followed by those given TU, compared with TB (all P <.001 between groups). Body weight increased significantly during T exposure. This effect was stronger and more sustained in TB vs TU or TE (both P <.001). Serum creatinine and hemoglobin increased with high significance in all T-treated animals (all P <.001 vs controls). The lowering impact of T on serum lipids was markedly stronger in the longer-acting T preparations in comparison with TE, as were effects on purine metabolism (all P <.001). The pattern of exposure and degree of aromatization rather than overall exposure to T determine its effects in the preclinical primate model. Both fluctuations of androgen concentrations and the conversion rate to estradiol influence gonadal suppression as well as metabolism. These results have to be considered in men receiving treatment for hypogonadism or regimens for hormonal contraception.

This study seem to confirm that:

• Longer esters cause higher levels of estrogen
• Longer esters cause more water retention
• Longer esters cause more suppression of the HPTA
• Longer esters cause higher levels of nitrogen retention (muscle gain) in other words are more anabolic
• Shorter esters cause higher peak plasma levels

But is that true or is it just a matter of different injection frequency? If we look at the study test E was injected every 4 week, enanthate will clear by week 2-3 so the HPTA will never become completly suppressed with that protocol. That longer esters convert more rapidly to estrogen could have something to do with more being injected less frequently, however according to the study the shorter esters caused higher peak levels, which suggest longer esters are more prone to convert to e2 through another pathway than increased aromatization from supraphysiological peaks.

 

[phenominal34]

From anecdotal evidence different esters have different pharmacokinetics - more than just half-life.

I found this A study on 3 different testosterone esters, short, medium and long esters



This study seem to confirm that:

• Longer esters cause higher levels of estrogen
• Longer esters cause more water retention
• Longer esters cause more suppression of the HPTA
• Longer esters cause higher levels of nitrogen retention (muscle gain) in other words are more anabolic
• Shorter esters cause higher peak plasma levels

But is that true or is it just a matter of different injection frequency? If we look at the study test E was injected every 4 week, enanthate will clear by week 2-3 so the HPTA will never become completly suppressed with that protocol. That longer esters convert more rapidly to estrogen could have something to do with more being injected less frequently, however according to the study the shorter esters caused higher peak levels, which suggest longer esters are more prone to convert to e2 through another pathway than increased aromatization from supraphysiological peaks.

Test E injected every 4 weeks ??? Huh ???

 

[Mac11wildcat]

This is a completely asinine study model to draw conclusions from to relate to the way we use testosterone….

 

[freakyjacked29]

• Longer esters cause higher levels of nitrogen retention (muscle gain) in other words are more anabolic

I have heard this also but need too look it up more