Lepodisiran

[Evac513]

Lepodisiran looks promising, wonder how long until we start getting it from ugl's.

 

[Photon]

This is probably something you'll never see from UGL.
Even if you do see it, its not something you want to use.

 

[Nidus]

This is probably something you'll never see from UGL.
Even if you do see it, its not something you want to use.

Yeah doubt that ANY UGL would ever has this and if, it would so crazy high expensive that your minimum quantity to order is like 100 Kits or so.
Maybe Lipid Expert @egruberman knows more.

 

[egruberman]

Yeah doubt that ANY UGL would ever has this and if, it would so crazy high expensive that your minimum quantity to order is like 100 Kits or so.
Maybe Lipid Expert @egruberman knows more.

Being a siRNA, my first thought was, "no fucking way are they going to replicate this in China." This is based on the difficulty with which they could replicate biologics like evolocumab.

Then I did some actual research into it and... Oligonucleotide synthesis is routine. Lipid nanoparticles are already being used and they've already developed or are developing a couple of siRNA drugs. As such, the capability exists. Whether or not a UGL could or would exploit that capability is anyone's guess.

My guess is that this has limited application and likely wouldn't be worth the effort. It's going to be effective for those with elevated Lp(a) which is a small subset of the population that is otherwise at risk for ASCVD.

I think we'd be more likely to see inclisiran before this which targets the PCSK9 mRNA and would be more broadly efficacious than something targeting Lp(a). Given the difficulty in synthesizing evolocumab, I wager we'd see this first, if in fact a UGL can get their hands on it.

Even so, do you want to fuck with your genes using a UGL compound? Don't answer. As soon as there's a UGL myostatin inhibitor y'all are all gonna be on it (me too).