hungryalways
Member
I just received the results from an LP(a) blood test, and unfortunately, it's on the high side at around 52 ng/dL / 110 nmol/L.
I had previously been running HGH for around 18 months at around 2 IU/day but had around a 6-week unrelated break before running the LP(a) bloods.
I was blissfully unaware that HGH can affect LP(a), but it seems that HGH does in fact raise LP(a) significantly.
My case may well be hereditary, but I'm curious as to any other experiences running LP(a) during or after running HGH.
Here is the literature I came across. There is evidence of LP(a) returning to baseline after 6 weeks to 3 months:
Study 1:
pubmed.ncbi.nlm.nih.gov
Three months after the cessation of GH therapy, serum Lp(a) levels were not significantly different from the pre-treatment values.
Study 2:
Serum Lp(a) concentrations increased in all patients after only 6 weeks of treatment (205 ±13% of pretreatment values, mean±SEM) and remained increased after 26 weeks of treatment (196±16% of pretreatment values).In the four patients who started on active treatment, Lp(a)concentrations decreased to pretreatment concentrations 6 weeks after rhGH withdrawal (Figure 2).
Study 3:
pubmed.ncbi.nlm.nih.gov
Overnight fasting blood samples were collected immediately before and after 6 months hGH treatment. In all but one of the children there was a significant increase in serum Lp(a) over the 6 month treatment period -(+)66.7% over the basal levels (range 14 to 180%). After the hGH treatment, in six children Lp(a) levels were elevated to above 300 mg/l, the cut-off level for increased coronary artery disease (CAD) risk.
Study 4:
However, after 12 months of treatment, the Lp(a) concentration had increased by 44% and 101% above baseline and the control group, respectively. Men and women responded differently to GH, with a more marked increase in Lp(a) concentration and fat-free mass and a more pronounced decrease in body-fat mass in men.
I had previously been running HGH for around 18 months at around 2 IU/day but had around a 6-week unrelated break before running the LP(a) bloods.
I was blissfully unaware that HGH can affect LP(a), but it seems that HGH does in fact raise LP(a) significantly.
My case may well be hereditary, but I'm curious as to any other experiences running LP(a) during or after running HGH.
Here is the literature I came across. There is evidence of LP(a) returning to baseline after 6 weeks to 3 months:
Study 1:
Increase of serum lipoprotein (a) levels during growth hormone therapy in normal short children - PubMed
Serum Lp(a) concentrations remained above pretreatment values during a 1-year period of GH treatment in short children without GH deficiency and declined shortly after cessation of therapy. Since GH therapy for short children without GH deficiency usually continues for several years, we suggest...
pubmed.ncbi.nlm.nih.gov
Study 2:
Serum Lp(a) concentrations increased in all patients after only 6 weeks of treatment (205 ±13% of pretreatment values, mean±SEM) and remained increased after 26 weeks of treatment (196±16% of pretreatment values).In the four patients who started on active treatment, Lp(a)concentrations decreased to pretreatment concentrations 6 weeks after rhGH withdrawal (Figure 2).
Study 3:
Growth hormone treatment increases circulating lipoprotein(a) in children with chronic renal failure - PubMed
Cardiovascular disease is the major cause of death in chronic renal failure (CRF) patients managed by dialysis or kidney transplantation. Whilst the use of human growth hormone (hGH) is of established benefit in CRF children particularly in those with short stature, in the present study we...
pubmed.ncbi.nlm.nih.gov
Study 4:
However, after 12 months of treatment, the Lp(a) concentration had increased by 44% and 101% above baseline and the control group, respectively. Men and women responded differently to GH, with a more marked increase in Lp(a) concentration and fat-free mass and a more pronounced decrease in body-fat mass in men.
