The “cancerine” stuff is all from rat studies at absurd mg/kg doses
If you wanna take narrow scope rat studies as proof positive for results in humans that’s on you. The studies have extreme limitations, that is all I’m saying.You realize it doesn't translate linearly mg to mg, rat to human? You can reference the study and I'll do the conversion for you.
If you wanna take narrow scope rat studies as proof positive for results in humans that’s on you. The studies have extreme limitations, that is all I’m saying.
I wanna use it badly but the cancer studies are stopping me from doing it.
It improve lipids and endurance in rats it also causes cancer in rats , so wouldn't we assume is the same for humans?
Also can be taken once pre event style would it still work ? Like a pre workout
In the rat study i believe the rats were given 10mg. This would equate 200-400mg for a human.
So the way I understand this, is that we almost sure that it causes cancerFrom the Geiger rat study that everyone loves to misrepresent, all doses trialled were associated with various cancers (e.g., stomach squamous cell papilloma in males at 5 mg/kg/day, the lowest dose trialled). 5 mg/kg/day in rat is equivalent to 0.81 mg/kg/day in adult man (the opposite of how it's reported), or ~65 mg daily for an 80 kg man.
The lowest dose (3 mg/kg) in females was shown to be carcinogenic. A 3 mg/kg/day cardarine dose is equivalent to ~24 mg daily for a 50 kg (110 lb) woman.
Anyhow, rodent carcinogenicity assays are not intended for assessing dose/response in man; instead, they are used to screen for potentially dangerous (carcinogenic) drugs. Since cardarine is profoundly carcinogenic it was not pursued to market.
See Bond, P. The Rise and Fall of Cardarine (GW501516). Sep 2021. Source: The Rise and Fall of Cardarine (GW501516) - MESO-Rx
There's really no "almost" here, we absolutely know it causes cancer.So the way I understand this, is that we almost sure that it causes cancer
Couldn't be more clear , thank youThere's really no "almost" here, we absolutely know it causes cancer.
Just as heavy tobacco smoking does not assure cancer, Cardarine use does not assure cancer (but certainly causes it).