low IGF-1 ,LH ,FSH . and klinefelter syndrome .

[medo84]

Hi,
I found out that I suffer from a chromosome problem called Klinefelter's syndrome "XXY 47" I am a male and been married for past 10 years with a wonderful fine lady, 6 years ago I found out about my problem and started treatments.
currently, I am taking TRT "test-E (Cidoteston 200mg" every 10 days " and .25 Arimidex EOD " " I started Arimidex only lately only for past 5 weeks" also I am taking medicine for uric acid as I had gout attack 2 months ago
as I started to have a good level of T in my blood my life went much better and I started to take care of myself as you know low T makes people damn depressed and lazy, now I am much more alive.
so, I made a checkup lately and would like you guys to take a look at it and tell me your opinion. And how well my protocol is working and if I should adjust anything around.
my current problems are:
sever PME, depressed, 20 kg of extra water retain.
currently, I am on Ketogenic diet with 20% defect.
I am 181 cm tall, and 161 kg. BMI 49.8 PBF 50%
my results are the following: “this test been made at 8:30 AM the day right after my T- shoot.

CBC
hematocrit 46% (N.40-53)
hemoglobin 15.7 N.13-18 d/l
RBCS 5.4 n4.5-6.5 x10^6ul
MCV 86.3 n80-94 fL
MCH 29.1 n27-33 pg
MCHC 33.7 n31-36 g/dl
RDW 13.9 n11.5-14.5 %
**Leucocytic count 14.06 N.4-11 x10^3/ul **
Comment (Leucocytosis with absolute neutrophilia)
Fasting blood glucose 106 N.70-110 mg/dl
Total cholesterol 248 N. upto200 mg/dl
Uric acid 4.6 nm:3-7 mg/dl
Cystatin C .81 N.63-1.33 mg/L
GFR 120 n59-137 ml/min
Albumin / creatinine in urine 8.6 N.less than 30 mg/alb/g creat
Urinary albumin 20.8 mg/L
Urinary creatinine 2.42 g/L
Total serum bilirubin .31 N.upto 1 mg/dl
Direct serum bilirubin .11 Upto .25 mg/dl
ALT (SGPT) 18 N.m upto 41 U/L
AST (SGOT) 14 N.m upto 40 U/L
Serum albumin 4.2 N.3.5-5.4 g/dl
ESR (first hour) 8 N.M: less than 13
Second hour 21
HORMONES:
LH 0.23 N.M 0.8-9.1 mIU/ml
FSH 1.12 N.M 1.6-11 mIU/ml
E2 21.8 N.M upto 45 pg/ml
SHBG 25.1 N.M 14.5-48.5 nmol/L
Testosterone 9.98 N.M 2.6-10.1 ng/ml
Free Testosterone 281 N.M 50-300 pg/ml
DEHA -s 323 N.M 59-452 ug/dl
Cortisol AM 8.32 N.M 5-25 ug/dl
Insulin like growth factor -1 IGF-1 66.1 n115-307 ng/ml
Reference ranges were corrected for age.
fT3 2.98 n1.68-3.54 pg/ml
fT4 1.32 n0.9-1.9 ng/dl

Many thanks for your time and sorry for my nonperfect English .

 

[heady muscle]

Interesting. Never heard of
klinefelter syndrome

For the gout, what is your diet like?

 

[medo84]

I have been on ketogenic diet for 2 years everything was very fine with gout than one day I started to eat freely loads of sweets and carbs than my gout hit me back big time . now I stopped eating trash and things start to get back to normal . my biggest concern here is my very low IGF- 1 FSH and LH . I feel so depressed and lacking any motives to do anything at all .

 

[heady muscle]

I have been on ketogenic diet for 2 years everything was very fine with gout than one day I started to eat freely loads of sweets and carbs than my gout hit me back big time . now I stopped eating trash and things start to get back to normal . my biggest concern here is my very low IGF- 1 FSH and LH . I feel so depressed and lacking any motives to do anything at all .

maybe someone with more knowledge can help:
@Dr JIM @Michael Scally MD

 

[Dr JIM]

I have been on ketogenic diet for 2 years everything was very fine with gout than one day I started to eat freely loads of sweets and carbs than my gout hit me back big time . now I stopped eating trash and things start to get back to normal . my biggest concern here is my very low IGF- 1 FSH and LH . I feel so depressed and lacking any motives to do anything at all .

Post a COPY of your LAB REPORTS.

 

[Savagesteve]

And make sure you don't post any personal info OP.

 

[Dr JIM]

Lol sorry I didn't see your lab had already been posted.

 

[Dr JIM]

If you have a genetic disorder such as KS your physician rather than a PED forum is where you should seek answers to your questions.

 

[Docd187123]

I agree with Dr. Jim although I'll add the caveat that your LH aNd FSH are low bc you are on TRT. This is to be expected and nothing To worry about as it can't be avoided.

 

[Dr JIM]

If you have a genetic disorder such as KS your physician rather than a PED forum is where you should seek answers to your questions.

@medo84 I mention this bc it's VERY IMPORTANT you understand Klinefelter Syndrome is a VERY COMMON human sex chromosomal disorder effecting
roughly 1:500 males!

It's also important to note there is an increased incidence of DM, Thyroid, and certain "autoimmune" disorders in SOME patients with KS.

It's for these reasons and others, I suggest a search for the "opinions" of those on PED forums are unlikely to be beneficial, (and may even be harmful) especially from a therapeutic perspective.

To that end I would encourage you to ask your endo about a forum specifically directed at and designed for patients with KS.

JIM

 

[Dr JIM]

Out of curiosity I've a few questions with respect to your "gout DX"

1) what joints are involved?

2) how was this DX CONFIRMED?

3) what was your age at DIAGNOSIS.

Incidentally although "low T"
can be associated with depression, other contribution factors are often overlooked completely such as MORBID OBESITY, and KS once a DX of "low T" is rendered.

Finally why in the heck are you trying another "diet" bc rest assured it will fail unless you change your lifestyle fella.

And I'm not saying this to be "mean" but after some 20 years of practice and being very familiar with the "obesity" literature, the outcome remains essentially the same; initial "diet" "success" followed by return to ones baseline AND some EXTRA!