Lyle Mcdonald Interview Discussing His New Book, "The GLP-1 Solution"

[aljowa]

People in this forum might find this informative. It's a three-hour interview discussing the highlights and main contents of the book, so quite in-depth; a decent compromise for those who don't want to purchase and read the actual book. Regardless of your personal opinion of Lyle McDonald, I've never come across a substantial critique regarding the intellectual rigor of his content. Anyone interested in the 'GLP-1 revolution' should glean some insight from this interview.


View: https://youtu.be/t7T6Dii-90Q?si=nzv-k4Ed8HnDMV2x

 

[readalot]

People in this forum might find this informative. It's a three-hour interview discussing the highlights and main contents of the book, so quite in-depth; a decent compromise for those who don't want to purchase and read the actual book. Regardless of your personal opinion of Lyle McDonald, I've never come across a substantial critique regarding the intellectual rigor of his content. Anyone interested in the 'GLP-1 revolution' should glean some insight from this interview.


View: https://youtu.be/t7T6Dii-90Q?si=nzv-k4Ed8HnDMV2x

Thank you very much for sharing. This dude really knows the deep dive. I hope he is doing well.

Very fitting he was predicting this drug class or at least make prophetic comments about them more than 20 years ago.

 

[xrayphoton13]

Lyle is the first person to teach me how metabolism and dieting really work all the way back in 2009. Before that I was reading Flex magazine and the bodybuilding forums thinking I needed to eat at least 2k calories to diet or I'd lose muscle and go into"starvation mode." After reading the rapid fatloss handbook I dropped 75 lbs in a few months. It was a freaking life changer. Lyle rubs a lot of people the wrong way but all of his books are top notch. I really enjoyed the guide to flexible dieting and the stubborn fatloss solution. UD2.0 was also great bc I got to pig out on carbs every weekend but the two glycogen draining workouts per week ultimately were too much for me to maintain it for more than 2 months

 

[BrunoES]

Listened to it today. Pretty informative, brings a lot about the history of the GLP-1's agonists, the mechanism of action, etc. Pretty general info, but I would recommend it. 3h is a lot though lol

 

[readalot]

for those who don't want to purchase and read the actual book.

Purchased. Thanks again Sir.

 

[aljowa]

Listened to it today. Pretty informative, brings a lot about the history of the GLP-1's agonists, the mechanism of action, etc. Pretty general info, but I would recommend it. 3h is a lot though lol

Helps to have it playing in the background during a non-cognitive intensive task (e.g., cardio, cleaning, driving, lifting, etc). I just put it on while I was lifting yesterday. Got about halfway through. This evening's lifting session should take me through the rest. Otherwise, yeah, it is a marathon interview. Playing it at 1.2× - 1.5× speed could help, as well.

 

[aljowa]

Purchased. Thanks again Sir.

Nice! He did mention during the interview that he goes more in-depth on a lot of the topics compared with the interview, and also there is a good amount of content contained in the book that they don't discuss here. Let us know how you like the book. I'm probably gonna get a copy myself. It's only $10, I believe.

I'm very eager to see the future iterations of these drugs that are in development, or will be in development in the next decade. Lyle himself mentions half-jokingly that this class of drugs are going to put him out of a job, and the only thing preventing that reality is the staggering cost of most of them to the general population (at least until those pharma patents expire).

 

[readalot]

Nice! He did mention during the interview that he goes more in-depth on a lot of the topics compared with the interview, and also there is a good amount of content contained in the book that they don't discuss here. Let us know how you like the book. I'm probably gonna get a copy myself. It's only $10, I believe.

I'm very eager to see the future iterations of these drugs that are in development, or will be in development in the next decade. Lyle himself mentions half-jokingly that this class of drugs are going to put him out of a job, and the only thing preventing that reality is the staggering cost of most of them to the general population (at least until those pharma patents expire).

I paid 25 bucks for the soft cover. Almost went for the hard cover. Love Lyle's mind and definitely need the book after listening to the vid on 2x. His prior books are excellent and still have my out of print BodyOpus.

Haven't spent much time with GLP-1 drugs so this will be fun. Maybe they will help me get to negative BF%. Love your posts Brother.

 

[aljowa]

I paid 25 bucks for the soft cover. Almost went for the hard cover. Love Lyle's mind and definitely need the book after listening to the vid on 2x. His prior books are excellent and still have my out of print BodyOpus.

Haven't spent much time with GLP-1 drugs so this will be fun. Maybe they will help me get to negative BF%. Love your posts Brother.

Not bad, I think I was thinking $10 for the e-book. I definitely admire Lyle's intellect and no-bullshit approach to fitness and nutrition content. No marketing gimmicks or social media pandering, just plain, old, dry quality information - my preferred way to ingest informative content.

I'm new to them myself. I will say Tirzepatide has made my cut feel pretty effortless, and I've always had a large appetite. Finally seeing that one ab vein I have again after my two-and-a-half-year dreamer bulk, haha. We're all gonna get there, good sir. And much appreciated! Just trying to contribute what tiny bits I can to elevate the community here. I've come across many of your posts over the past months, and I've thrown many upvotes your way; good stuff.

 

[BrunoES]

Out of curiosity, what weight and BF did you start Tirzepatide at? And how did it go? I am looking into incorporating it at a very small dose, to help maintain a lower BF without all the mental stress. Getting lean is pretty easy for me, staying lean without stress is a whole other deal

 

[aljowa]

Out of curiosity, what weight and BF did you start Tirzepatide at? And how did it go? I am looking into incorporating it at a very small dose, to help maintain a lower BF without all the mental stress. Getting lean is pretty easy for me, staying lean without stress is a whole other deal

5'10", ~235 lbs start weight. Body fat %, hmm, I'm trying to go off mid-section definition, because my arms always look vascular. I was fluffy with *slight* outer abdominal indentations. Probably 20-22%? Right now I'm 215, probably around 16-17% body fat, give or take (if I flex my abs I can see a pretty clear four-pack upper abs). Doing the "jump test," nothing jiggles in my torso except for pec muscles; make of that what you will.

I think in your situation, low-dose semaglutide or tirzepatide would definitely stave off hunger, or "food noise," as people say. Full disclosure, I'm on 15mg tirzepatide, but my appetite can be wicked, and honestly I feel like I've always needed higher doses of all substances to feel effects, from clen to adderall to anabolics to modafinil to caffeine to alcohol. It's weird; sometimes I feel like I'm a low responder to stuff, but at the same time I'm a low responder to side effects as well. It's like I just need to amplify my doses of everything to get the same effects most people do at half the dose. I ran 800mg of tren E with 500mg test E last year and felt no side effects, mental or physical, except for some acid reflux.

But I can relate heavily to you on the maintaining leanness. I am excellent at gaining and losing weight, terrible at maintaining, lol. It's a work in progress.

 

[BrunoES]

@aljowa this question was directed to you, I forgot to quote you lol

Out of curiosity, what weight and BF did you start Tirzepatide at? And how did it go? I am looking into incorporating it at a very small dose, to help maintain a lower BF without all the mental stress. Getting lean is pretty easy for me, staying lean without stress is a whole other deal

 

[aljowa]

@aljowa this question was directed to you, I forgot to quote you lol

No worries. I replied, but my message is awaiting moderator approval. Should hopefully be cleared soon and you'll see it.

I suspect it's because I used a certain word, lol.

 

[BrunoES]

No worries. I replied, but my message is awaiting moderator approval. Should hopefully be cleared soon and you'll see it.

I suspect it's because I used a certain word, lol.

Ah, I've been there, and it doesn't solve the problem if you go back and try to edit it, I've tried it

 

[AlexDavis43]

Lyle provides great information about training but he's such a dork. Like five times in this video, he said "and we all know athletes never do anything illegal!" *wink wink*

Ok bud, we know. That hasn't been funny since the 90s.

 

[BrunoES]

5'10", ~235 lbs start weight. Body fat %, hmm, I'm trying to go off mid-section definition, because my arms always look vascular. I was fluffy with *slight* outer abdominal indentations. Probably 20-22%? Right now I'm 215, probably around 16-17% body fat, give or take (if I flex my abs I can see a pretty clear four-pack upper abs). Doing the "jump test," nothing jiggles in my torso except for pec muscles; make of that what you will.

I think in your situation, low-dose semaglutide or tirzepatide would definitely stave off hunger, or "food noise," as people say. Full disclosure, I'm on 15mg tirzepatide, but my appetite can be wicked, and honestly I feel like I've always needed higher doses of all substances to feel effects, from clen to adderall to anabolics to modafinil to caffeine to alcohol. It's weird; sometimes I feel like I'm a low responder to stuff, but at the same time I'm a low responder to side effects as well. It's like I just need to amplify my doses of everything to get the same effects most people do at half the dose. I ran 800mg of tren E with 500mg test E last year and felt no side effects, mental or physical, except for some acid reflux.

But I can relate heavily to you on the maintaining leanness. I am excellent at gaining and losing weight, terrible at maintaining, lol. It's a work in progress.

Seems like you are resistant to dosages, in general. As long as the side effects are following this resistance, its mostly a matter of costs, I believe.

I am planning on trying something in the ballpark of 2.5mg/week of Tirz and see how it goes.

I already maintain where I am at, but having to hammer down high volumes of low calorie foods is just unsustainable long term, IMO.

What I am mostly looking to achieve is for my brain to realize its satiated, and with this BF I am at, I can get physically full, but neurologically wise, my brain simply doesn't register it lol

 

[aljowa]

Seems like you are resistant to dosages, in general. As long as the side effects are following this resistance, its mostly a matter of costs, I believe.

I am planning on trying something in the ballpark of 2.5mg/week of Tirz and see how it goes.

I already maintain where I am at, but having to hammer down high volumes of low calorie foods is just unsustainable long term, IMO.

What I am mostly looking to achieve is for my brain to realize its satiated, and with this BF I am at, I can get physically full, but neurologically wise, my brain simply doesn't register it lol

Your last sentence here hits my soul, lol. I can relate on a deep level with that one. I feel as if my relationship with food is warped on psychological level. I've never been morbidly obese or anything, but it's always been a struggle to stave off appetite for me. My primary strategy to overcome this before GLP-1s was to just keep my mind occupied; an idle mind was my worst enemy when it came to appetite.

I can also relate to the unsustainability of a high-volume, low calorie-density diet. The physical discomfort and general lethargy from being stuffed all the time gets old fast, especially when it feels like you have a bowling ball in your stomach at bedtime, lol.

I wish you all the best with the Tirzepatide, and I hope you find it helps achieve your goal of turning down the food noise volume psychologically. I do wonder, though: why start with tirz and not semaglutide? Semaglutide is cheaper and has a higher binding affinity to your endogenous GLP-1 receptors (I believe around twice as much). It is the most potent of the available GLP-1s when it comes to pure appetite suppression (on paper, at least). You may find that a low-to-moderate dose of semaglutide is sufficient to achieve the effects you desire, and would be cheaper in the long run.

 

[BrunoES]

Your last sentence here hits my soul, lol. I can relate on a deep level with that one. I feel as if my relationship with food is warped on psychological level. I've never been morbidly obese or anything, but it's always been a struggle to stave off appetite for me. My primary strategy to overcome this before GLP-1s was to just keep my mind occupied; an idle mind was my worst enemy when it came to appetite.

I can also relate to the unsustainability of a high-volume, low calorie-density diet. The physical discomfort and general lethargy from being stuffed all the time gets old fast, especially when it feels like you have a bowling ball in your stomach at bedtime, lol.

I wish you all the best with the Tirzepatide, and I hope you find it helps achieve your goal of turning down the food noise volume psychologically. I do wonder, though: why start with tirz and not semaglutide? Semaglutide is cheaper and has a higher binding affinity to your endogenous GLP-1 receptors (I believe around twice as much). It is the most potent of the available GLP-1s when it comes to pure appetite suppression (on paper, at least). You may find that a low-to-moderate dose of semaglutide is sufficient to achieve the effects you desire, and would be cheaper in the long run.

I actually was just talking to Ghoul about it, I am going to purchase both and see which one works the best for my situation. One of Tirz benefit, from what I have seen, is the lower side effect profile.
The one side effect I would really like to avoid is the slow gastric emptying, but maybe on a very low dose of Sema it wouldn't appear so much.
I am planning on trying (and hopefully staying on) either 0.10mg of Sema/week or 2.5mg of Tirz/week.

 

[readalot]

So I went through the book last night and fortunately/unfortunately depending on your persuasion it is no where near as detailed as Lyle's previous Ketogenic Diet compendium.

To be quite honest it seems like he just cranked it out as part of the GLP-1 craze. Lots of typical basic diet, fat loss, body fat info but that's also just redux from his prior books and Duchaine's Bodyopus.

That being said I am sure it would potentially help the beginner and I am probably a poor target audience member for his book. The section on lean people using GLP-1 drugs really has next to nothing (appendix).

Thanks again the video @aljowa. I think if someone was to watch that video diligently there is very little else they would get from the book. Definitely not a specialized text on the use of GLP-1 drugs for bodybuilders/lean people, but my expectation going in was probably was too high. Of course it was extremely generous for Lyle to do the video free of charge!

In summary, I don't agree with last sentence in the Introduction... "A complete guide to the GLP-1s containing everything you could ever need to know."

 

[BigTomJ]

Lyle could be 100% right

but being the colossal cry baby, no citation claims, drama starting cunt he is I would never be able to put much stock in anything he has to say.