Interesting post from Reddit, which among other things explains why I sleep like shit on Mk:
“The benefits of using MK-677 will never become comparable to the side effects you're currently experiencing. MK-677 is a ghrelin receptor agonist, so you should probably look up what ghrelin does physiologically to see what you'll experience.
Ghrelin an agonist of the ghrelin receptor. Ghrelin is an orexigenic neuropeptide that inhibits normal cycling between sleep stages, via its tonic and phasic action on the arcuate nucleus of the hypothalamus. Ghrelin release normally follows the circadian rhythm (tonic control), so your body has the lowest amounts before falling asleep, then ghrelin increases steadily before waking up to inhibit sleep. Ghrelin also increases before meal time (phasic control). Basically, if you gave anyone ghrelin, you expect them to be hungry and less able to switch to Slow Wave Sleep, the component of sleep that's important for cognition and memory.
People on here recommend taking MK 677 immidiately before sleep, which goes to show you how broscience dominates bodybuilding. Those people are dumb. If you wanted to enhance the physiological role of ghrelin you'd have to take it a few hours before waking up (like if you go pee in the middle of the night), immidiately upon waking, or before meal times. If you take ghrelin before sleep you WILL have poor quality sleep, fat gain, and arguably a temporary cognitive decline from less SWS. Gastrointestinal distress is the only symptom you're describing that I'd classify as a side effect. The rest is entirely to be expected, and won't go away.
Even if you were to inject yourself with hGH, it'd still take you months to see the positive effects. MK-677 achieves a much more mild increase in growth hormone than hGH injections, so you should expect to wait a few times longer to see an actual benefit besides placebo. MK-677 is effective for weight gain, particularly of fat, but not for anything a bodybuilder would want to use it for.”
