Please see below, sorry for the long post.
I did my 1st blood test 7/15/2009. The reason I did this test was because I had zero sex drive, no energy, storing fat and just felt mentally very unclear. I was working out hard and have always ate very clean and was still holding the fat no matter what I did. So I did the test below.
7/15/2009
Test- 453 (241-827)
Free Test (Direct) 9.8 (8.7-25.1)
TSH- 1.350 (.450-4.5)
DHEA- 267 (120-520)
IGF-1- 146 (115-307)
Then on 7/28/2009 we did more testing to see if we could determine why test and especially free test were low.
7/28/2009
LH- 1.5 (1.5-9.3)
FSH- 2.4 (1.4-18.1)
Estrodial- 31 (0-53)
7/30/2009 Doctor decided to inject 200MG of depo Test and retest levels which we did on 8/04/09
TSH .596 (.450-4.500) WOW, super odd not sure what happened here???
T4- 1.31 (.61-1.76)
TEST- 1467 (241-827)
FREE TEST- 39.9 (8.7-25.1)
During this time I felt great sex drive was finally back, great moods, very alert, memory was greatly improved and so on. My doctor did not know much about injecting test the 1467 test number scared him so he said no second injection.
We tested on 8/13/2009 as he wanted to see what my levels were at now. During this time I felt about the same as I used to feel before the shot, like ****, i did feel a little worse I was a little more tired and got headaches.
8/13/2009
Test- 182
Free Test- 4.1
Prolactin- 4.7 (2.1-17.7)
8/14/2009 I did some research about re-start protocols and talked my doctor into one of them
I took HCG m,w,f 300mg injected for 3 weeks total
Clomid 100mgs a day split 50mg morning and 50 mg afternoon 4 weeks
Nolva 20 mg, 10 morning and 10 at night 4 weeks
I felt better on this and for about 2 months after it but I have slowly started to feel like **** again. HCG took fat off me like no other, sorry for the side note.
We retested on 9/30 about 2 weeks after the end of the restart.
9/30/2009
Test 579
Free Test 14.1
LH- 5.7
I have started to feel like **** again, no sex drive what so ever, no morning wood, very moody, no zest for life, no energy, mentally unclear and so on. So we re-tested on 1/12/2009
1/12/2009
DHEA 691 (146-850)
TEST 563
FREE TEST 11.7
LH 3.8
Next We Ran Some Thyroid and other test 2/4/10
Thyroid Antibodies
TP0- 16 (0-34)
AB- <20 (0-40)
Vitamin B-12- 1075 (211-911)
Free T4- 1.70 (.82-1.77)
TSH- 1.050 (.450-4.5)
Vitamin D- 42.2 (32.0-100.0)
Estradoil- 9.5 (7.6-42.6)
Reverse T3 380 (90-350)
Ferritin, Serum- 868 (22-322)
Free T3- 3.0 (2.0-4.4)
SHBG- 55.7 (14.5-48.4)
WOW how many things can go wrong at once. I think the SHBG would explain my low free test and I think the SHBG is what is killing my sex drive, desire and so on. I have been told that reverse T3 is the hidden Hypo. high reverse T3 mimics hypothyroidism and drops your body temperature/slows your metabolism. even if you are not clinically hypo according to your freeT3 and freeT4, you are still EFFECTIVELY HYPOTHYROID because your reverse T3 is blocking your freeT3 from working.
I am not sure what to do or where to go from here. I guess I am at least headed in the right direction it is just frusterating. Why in the hell would my SHBG be so high and how do I lower it???
My Doctor was concerned with my Ferritin so we ran some iron test along with a CBC 2/11/2010
TRANSFERRIN SAT
Iron 117 (45-182)
Transferrin Sat 34 (20-50)
Transferrin 249 (215-365)
LH 4.3 (1.7-8.6)
FSH 2.5 (1.5-12.4)
Iron Serum 119 (40-155)
CBC
wbc 5.4 (4-10.5)
rbc 4.99 (4.20-6.0)
hemoglobin 15.5 (13.0-18.0)
hematocrit 44.7 (37-55)
mcv 90 (80-98)
mch 31 (27-34)
mchc 34.6 (32.0-36.0)
rdw 13.4 (11.7-15)
platelets 158 (140-415)
neutrophils 52 (40-74)
lymphs 38 (14-46)
monocytes 7 (4-13)
eos 3 (0-7)
basos 0 (0-3)
neutrophils absolute 2.8 (1.8-7.8)
lymphs absolute 2.1 (.7-4.5)
monocytes absolute .4 (.1-1.0)
eos absolute .2 (.0-.4)
baso absolute .0 (.0-.2)
Ferritin Serum 828 (22-322)
Everything thing looked good except ferritin so doc referred me to a Hemotologist who ran the following test
CBC
wbc 6 (4-10)
rbc 4.97 (4.60-6.2)
hemoglobin 15.4 (13.0-18.0)
hematocrit 45.7 (42.0-52.0)
mcv 91.9 (81-98)
mch 31 (27-32.5)
mchc 33.7 (32.0-36.0)
rdw 12.7 (11.5-14.5)
platelets 161 (150-400)
mpv 9.4 (7.4-10.4)
neutrophils 49 (40-75)
lymphs 38.3 (19-45)
monocytes 6.7 (0-12.0)
eos 4.6 (0-6.0)
basos .5 (0-2.0)
neutrophils absolute 3.0 (1.0-6.0)
lymphs absolute 2.3 (1.0-3.0)
monocytes absolute .4 (0-0.8)
eos absolute .3 (.0-.4)
baso absolute .0 (.0-.2)
esr 3 (0-10)
protime 13.9 (11.6-15.1)
APTT 26.4 (24.0-35.0)
CMP BASIC
Sodium 139 (134-144)
Potasium 4.1 (3.4-5.1)
Chloride 104 (101-112)
CO2 28.4 (22-32)
Anion Gap 7 (4-15)
Glucose 103 (70-110)
BUN 19 (8-20)
CREAT 1.24 (.7-1.3)
BUN/CR Ration 15.3 No Range Given
Calcium 9.2 (8.9-10.3)
Tot Protein 7.1 (6.5-8.5)
Albumin 4.5 (3.5-4.8)
Tot Bili: 1.3 (.3-1.2) HIGH
ALK PHOS: 82 (38-126)
AST 25 (15-41)
Globulin 2.6 (2.3-3.9)
A/G Ration 1.7 No Range Given
Alt 35 (17-63)
LDH 125 (98-228.6)
RF <20 (0-20)
B-2 Microglob 1.13 (.0-1.73)
HEP A AB, IGM- NEGATIVE
HEP B COR IGM- NON- REACTIVE, Not sure what "non-reactive means" I am praying it is not bad??
HEP B SUR AG- NEGATIVE
HEPATITIS C AB- NEGATIVE
ANA came back at >7.5 which on the scale is negative
Hemachromatosis testing Method:
A PCR-based assay was utilized to test for the following 3 mutations in the HFE gene. C282Y, H63D and S65C. Because of the minimal effect on iron metabolism associated with the S65C mutation, it is only report when it is found with the C282Y mutation.
Results:
C282Y - Not Detected
H63D - Heterozygous. One Copy of the H63D mutation identified
Interpretation:
These results suggest a low risk for either a diagnosis of the hereditary Hemachromatosis (HH) or a predisposition for (HH)
The diagnosis of (HH) can not be excluded since approx. 2 to 4% of patients with (HH) in a North American Caucasian population have this genotype. However this genotype is also found in approx 20 to 30% of clinically normal individuals. For other ethnic or racial groups, the % of HH patients with this genotype may differ. Additionally, these results do not rule out the possibility of the disease causing mutations in other regions of the HFE genes. These results, therefore, need to be interpreted in the context of the clinical presentation and the results of the other laboratory.
At this point my hemotologist has ruled out most possibities, I also did an HIV/Aids test which was negative. She believes I have iron storage problems due to the gene mutation. I asked her if this was just because she had nothing else and she said no she actually has patients with this exact mutation and the iron storage problems. At this point I am going to give 500cc of blood, wait 2 weeks check hg>15.5 then go ahead and draw another 500CC then check ferritin again.
Now that I have the ferritin under control I would like to figure out thyriod high SHBG. My total test is good it is my free test that is getting gobbled up by the SHBG. If any one has any suggestions or know of a good doctor in Colorado that would be great. Thanks
I did my 1st blood test 7/15/2009. The reason I did this test was because I had zero sex drive, no energy, storing fat and just felt mentally very unclear. I was working out hard and have always ate very clean and was still holding the fat no matter what I did. So I did the test below.
7/15/2009
Test- 453 (241-827)
Free Test (Direct) 9.8 (8.7-25.1)
TSH- 1.350 (.450-4.5)
DHEA- 267 (120-520)
IGF-1- 146 (115-307)
Then on 7/28/2009 we did more testing to see if we could determine why test and especially free test were low.
7/28/2009
LH- 1.5 (1.5-9.3)
FSH- 2.4 (1.4-18.1)
Estrodial- 31 (0-53)
7/30/2009 Doctor decided to inject 200MG of depo Test and retest levels which we did on 8/04/09
TSH .596 (.450-4.500) WOW, super odd not sure what happened here???
T4- 1.31 (.61-1.76)
TEST- 1467 (241-827)
FREE TEST- 39.9 (8.7-25.1)
During this time I felt great sex drive was finally back, great moods, very alert, memory was greatly improved and so on. My doctor did not know much about injecting test the 1467 test number scared him so he said no second injection.
We tested on 8/13/2009 as he wanted to see what my levels were at now. During this time I felt about the same as I used to feel before the shot, like ****, i did feel a little worse I was a little more tired and got headaches.
8/13/2009
Test- 182
Free Test- 4.1
Prolactin- 4.7 (2.1-17.7)
8/14/2009 I did some research about re-start protocols and talked my doctor into one of them
I took HCG m,w,f 300mg injected for 3 weeks total
Clomid 100mgs a day split 50mg morning and 50 mg afternoon 4 weeks
Nolva 20 mg, 10 morning and 10 at night 4 weeks
I felt better on this and for about 2 months after it but I have slowly started to feel like **** again. HCG took fat off me like no other, sorry for the side note.
We retested on 9/30 about 2 weeks after the end of the restart.
9/30/2009
Test 579
Free Test 14.1
LH- 5.7
I have started to feel like **** again, no sex drive what so ever, no morning wood, very moody, no zest for life, no energy, mentally unclear and so on. So we re-tested on 1/12/2009
1/12/2009
DHEA 691 (146-850)
TEST 563
FREE TEST 11.7
LH 3.8
Next We Ran Some Thyroid and other test 2/4/10
Thyroid Antibodies
TP0- 16 (0-34)
AB- <20 (0-40)
Vitamin B-12- 1075 (211-911)
Free T4- 1.70 (.82-1.77)
TSH- 1.050 (.450-4.5)
Vitamin D- 42.2 (32.0-100.0)
Estradoil- 9.5 (7.6-42.6)
Reverse T3 380 (90-350)
Ferritin, Serum- 868 (22-322)
Free T3- 3.0 (2.0-4.4)
SHBG- 55.7 (14.5-48.4)
WOW how many things can go wrong at once. I think the SHBG would explain my low free test and I think the SHBG is what is killing my sex drive, desire and so on. I have been told that reverse T3 is the hidden Hypo. high reverse T3 mimics hypothyroidism and drops your body temperature/slows your metabolism. even if you are not clinically hypo according to your freeT3 and freeT4, you are still EFFECTIVELY HYPOTHYROID because your reverse T3 is blocking your freeT3 from working.
I am not sure what to do or where to go from here. I guess I am at least headed in the right direction it is just frusterating. Why in the hell would my SHBG be so high and how do I lower it???
My Doctor was concerned with my Ferritin so we ran some iron test along with a CBC 2/11/2010
TRANSFERRIN SAT
Iron 117 (45-182)
Transferrin Sat 34 (20-50)
Transferrin 249 (215-365)
LH 4.3 (1.7-8.6)
FSH 2.5 (1.5-12.4)
Iron Serum 119 (40-155)
CBC
wbc 5.4 (4-10.5)
rbc 4.99 (4.20-6.0)
hemoglobin 15.5 (13.0-18.0)
hematocrit 44.7 (37-55)
mcv 90 (80-98)
mch 31 (27-34)
mchc 34.6 (32.0-36.0)
rdw 13.4 (11.7-15)
platelets 158 (140-415)
neutrophils 52 (40-74)
lymphs 38 (14-46)
monocytes 7 (4-13)
eos 3 (0-7)
basos 0 (0-3)
neutrophils absolute 2.8 (1.8-7.8)
lymphs absolute 2.1 (.7-4.5)
monocytes absolute .4 (.1-1.0)
eos absolute .2 (.0-.4)
baso absolute .0 (.0-.2)
Ferritin Serum 828 (22-322)
Everything thing looked good except ferritin so doc referred me to a Hemotologist who ran the following test
CBC
wbc 6 (4-10)
rbc 4.97 (4.60-6.2)
hemoglobin 15.4 (13.0-18.0)
hematocrit 45.7 (42.0-52.0)
mcv 91.9 (81-98)
mch 31 (27-32.5)
mchc 33.7 (32.0-36.0)
rdw 12.7 (11.5-14.5)
platelets 161 (150-400)
mpv 9.4 (7.4-10.4)
neutrophils 49 (40-75)
lymphs 38.3 (19-45)
monocytes 6.7 (0-12.0)
eos 4.6 (0-6.0)
basos .5 (0-2.0)
neutrophils absolute 3.0 (1.0-6.0)
lymphs absolute 2.3 (1.0-3.0)
monocytes absolute .4 (0-0.8)
eos absolute .3 (.0-.4)
baso absolute .0 (.0-.2)
esr 3 (0-10)
protime 13.9 (11.6-15.1)
APTT 26.4 (24.0-35.0)
CMP BASIC
Sodium 139 (134-144)
Potasium 4.1 (3.4-5.1)
Chloride 104 (101-112)
CO2 28.4 (22-32)
Anion Gap 7 (4-15)
Glucose 103 (70-110)
BUN 19 (8-20)
CREAT 1.24 (.7-1.3)
BUN/CR Ration 15.3 No Range Given
Calcium 9.2 (8.9-10.3)
Tot Protein 7.1 (6.5-8.5)
Albumin 4.5 (3.5-4.8)
Tot Bili: 1.3 (.3-1.2) HIGH
ALK PHOS: 82 (38-126)
AST 25 (15-41)
Globulin 2.6 (2.3-3.9)
A/G Ration 1.7 No Range Given
Alt 35 (17-63)
LDH 125 (98-228.6)
RF <20 (0-20)
B-2 Microglob 1.13 (.0-1.73)
HEP A AB, IGM- NEGATIVE
HEP B COR IGM- NON- REACTIVE, Not sure what "non-reactive means" I am praying it is not bad??
HEP B SUR AG- NEGATIVE
HEPATITIS C AB- NEGATIVE
ANA came back at >7.5 which on the scale is negative
Hemachromatosis testing Method:
A PCR-based assay was utilized to test for the following 3 mutations in the HFE gene. C282Y, H63D and S65C. Because of the minimal effect on iron metabolism associated with the S65C mutation, it is only report when it is found with the C282Y mutation.
Results:
C282Y - Not Detected
H63D - Heterozygous. One Copy of the H63D mutation identified
Interpretation:
These results suggest a low risk for either a diagnosis of the hereditary Hemachromatosis (HH) or a predisposition for (HH)
The diagnosis of (HH) can not be excluded since approx. 2 to 4% of patients with (HH) in a North American Caucasian population have this genotype. However this genotype is also found in approx 20 to 30% of clinically normal individuals. For other ethnic or racial groups, the % of HH patients with this genotype may differ. Additionally, these results do not rule out the possibility of the disease causing mutations in other regions of the HFE genes. These results, therefore, need to be interpreted in the context of the clinical presentation and the results of the other laboratory.
At this point my hemotologist has ruled out most possibities, I also did an HIV/Aids test which was negative. She believes I have iron storage problems due to the gene mutation. I asked her if this was just because she had nothing else and she said no she actually has patients with this exact mutation and the iron storage problems. At this point I am going to give 500cc of blood, wait 2 weeks check hg>15.5 then go ahead and draw another 500CC then check ferritin again.
Now that I have the ferritin under control I would like to figure out thyriod high SHBG. My total test is good it is my free test that is getting gobbled up by the SHBG. If any one has any suggestions or know of a good doctor in Colorado that would be great. Thanks
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