MESO-Rx
Anabolic Steroids
New miracle drug? Can reattach tendon to bone?!
- Thread starter tubesox
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Molecules. 2014 Nov 19;19(11):19066-77.
Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts.
Chang CH1, Tsai WC2, Hsu YH3, Pang JH4.
Abstract
BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat. From the result of cDNA microarray analysis, growth hormone receptor was revealed as one of the most abundantly up-regulated genes in tendon fibroblasts by BPC 157. BPC 157 dose- and time-dependently increased the expression of growth hormone receptor in tendon fibroblasts at both the mRNA and protein levels as measured by RT/real-time PCR and Western blot, respectively. The addition of growth hormone to BPC 157-treated tendon fibroblasts dose- and time-dependently increased the cell proliferation as determined by MTT assay and PCNA expression by RT/real-time PCR. Janus kinase 2, the downstream signal pathway of growth hormone receptor, was activated time-dependently by stimulating the BPC 157-treated tendon fibroblasts with growth hormone. In conclusion, the BPC 157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon.
Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts.
Chang CH1, Tsai WC2, Hsu YH3, Pang JH4.
Abstract
BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat. From the result of cDNA microarray analysis, growth hormone receptor was revealed as one of the most abundantly up-regulated genes in tendon fibroblasts by BPC 157. BPC 157 dose- and time-dependently increased the expression of growth hormone receptor in tendon fibroblasts at both the mRNA and protein levels as measured by RT/real-time PCR and Western blot, respectively. The addition of growth hormone to BPC 157-treated tendon fibroblasts dose- and time-dependently increased the cell proliferation as determined by MTT assay and PCNA expression by RT/real-time PCR. Janus kinase 2, the downstream signal pathway of growth hormone receptor, was activated time-dependently by stimulating the BPC 157-treated tendon fibroblasts with growth hormone. In conclusion, the BPC 157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon.
I think i read this right, correct me if im wrong. So if im running BPC 157 for its healing properties it would only make since to run something like ghrp-2 and grf 1-29 with it correct?
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i've been digging around datbtrue and i tell you what, i've never learned so much in a day...that place is awesome
michaltyler
New Member
Agreed. datbtrue is the peptide bible.
Any thoughts on running BPC 157 solo?
Any thoughts on running BPC 157 solo?
unless i read CBS post wrong, it seems like it just opens up receptor sites in the myofibrils..so yeh your natural GH should work just fine. But in order to really ramp up the healing process take GH releasers or just supplement it.
Would love for someone to tell me if im right or not though
michaltyler
New Member
That's what I was thinking... I just got some BPC 157, and I'm anxious to use it for my shoulders, just wanna get the most bang for my buck.
if it were me id take ghrp2 with it
@tileguy123 you'd prbably be interested in this stuff if you haven't heard of it already
hotdog23
New Member
This is what I got out of it
hotdog23
New Member
Oh and there is NO way it'll reattach tendon to bone unless said tendon is surgically anchored. And then it will. But it would without bpc-157 as well
So along with ghrp6 as well maybee?
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