MESO-Rx
Anabolic Steroids
Nolvadex and drug testing
- Thread starter PANTHRO
- Start date
einstein1905
New Member
http://www.rxlist.com/cgi/generic/tamox_cp.htmPANTHRO said:
Following a single oral dose of 20 mg tamoxifen, an average peak plasma concentration of 40 ng/ml (range 35 to 45 ng/ml) occurred approximately 5 hours after dosing. The decline in plasma concentrations of tamoxifen is biphasic with a terminal elimination half-life about 5 to 7 days. The average peak plasma concentration for N-desmethyl tamoxifen is 15 ng/ml (range 10 to 20 ng/ml).
Chronic administration of 10 mg tamoxifen given twice daily for three months to patients results in average steady-state plasma concentrations of 120 ng/ml (range 67 to 183 ng/ml) for tamoxifen and 336 ng/ml (range 148 to 654 ng/ml) for N-desmethyl tamoxifen. The average steady-state plasma concentrations of tamoxifen and N-desmethyl tamoxifen after administration of 20 mg tamoxifen once daily for 3 months are 122 ng/ml (range 71 to 183 ng/ml) and 353 ng/ml (range 152 to 706 ng/ml), respectively.
After initiation of therapy, steady state concentrations for tamoxifen are achieved in about 4 weeks and steady state concentrations for N-desmethyl tamoxifen are achieved in about 8 weeks, suggesting a half-life of approximately 14 days for this metabolite
After oral administration, tamoxifen is absorbed rapidly with maximum serum concentrations attained within 4 to 7 hours. Steady state concentrations (about 300 nanogram/mL) are achieved after four weeks treatment with 40mg daily. The medicine is highly protein bound to serum albumin (>99%). Metabolism is by hydroxylation, demethylation and conjugation, giving rise to several metabolites which have a similar pharmacological profile to the parent compound and thus contribute to the therapeutic effect. Excretion occurs primarily via the faeces and an elimination half-life of approximately seven days has been calculated for the medicine itself, whereas that for N-desmethyltamoxifen, the principal circulating metabolite, is 14 days.
So, after some calculations...if all of the metabolites were excreted throught the urine then it would take about three months to pass a drug test. Since it says that excreation is primarily through shit then the time is shorter than this. I'll see if I can find out what the excretion rate is through urine.
