Semaglutide sterilization procedure

thelettert

New Member
I’ve recently begun prep on a homebrew of semaglutide. Vials, bac water, autoclave. Etc.

Since the dosage is so small 2-4 mg, this would require a sophisticated lab grade balance to weigh out such small quantities. In my efforts to avoid this I am searching for a supplier that can customize raws - that could put a suitable excipient which would allow for greater ease when handling the powder. Thinking 100mg to 1mg semaglutide, my research has turned up mannitol as a possible excipient agent.

However assuming I could find a supplier willing to customize the raws prior to shipping (since I’m not entirely comfortable doing it myself - I would like to avoid the chocolate chip cookie effect)

How would one go about sterilizing the powder? My understanding is heat degrades semaglutide fairly easily but from chatting with a chemist friend, he seems to think 60 degrees celius for 10 hours in a glass vial would do the trick. I’m wondering how are these peptide sellers able to sterilize their raws? Or they just slapping it in a sterilized vial and hoping when the customer add the bac water, the small amounts of BA already in the bac water kills off any possible bacteria?

Questions: is it possible to have a raw supplier add an excipient agent so the powder is ready to brew

Will my sterilization procedure be sufficient without degrading the semaglutide?
 
yea I know, just the fact he is asking for something that is "ready to brew" lol
Yes this post was referring to lyophilized raw powders, I saw there was very little information on sterilization of semaglutide raws so was hoping someone would have some insights into the process
 
Take it easy on yourself. Just google "research peptides" and you will find lots of vendors ready to go. Unless you yourself are looking to sell peptides. Probablly the wrong forumn to get that advice.
 
Yes this post was referring to lyophilized raw powders, I saw there was very little information on sterilization of semaglutide raws so was hoping someone would have some insights into the process
Try chatGPT 4. You'll be surprised how much it can help with questions like this. Ask it to help you with writing a movie script ;)
 
...why?

just get a kit of 10 vials and use bac water, why are you trying to reinvent the wheel?
 
...why?

just get a kit of 10 vials and use bac water, why are you trying to reinvent the wheel?
It’s the same as homebrewing aas, he probably wants to save a little bit.

However, I think the process is different with these kinds of peptides, it is more complicated and requires sophisticated equipments. I could be wrong though, but I haven’t seen anyone here do homebrew glp-1s yet.
 
While making oral caps at 5mg are easy because you use a filler and simple math. I don't see it being easy or cost/time efficient to individually try to measure 5mg and put it into a sterilized vial.

I think this is something better left to a manufacturer with proper equipment
 
You aren’t going to lyophilize shit at home unless you have a tray-stoppering lyophilizer.
I don’t think you understand the process.

Sterilizing would be the least of your worries.
 
I’ve been curious since I’ve seen these peptide raws floating around, and there wasn’t much in the way of information into turning them into a usable form, appreciate the replies though

My understanding the raws are shipped lyophilized
 
If it was that easy, more people would be buying HGH raws and just "homebrewing" 100iu/vial.

You need advanced equipment to lypholize and vacuum seal the vials, and the measurement of such small amounts of product becomes an issue.
 
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