Switch from Retatrutide to Cagrilintide

[ExxMarine]

I’ve been taking Retatrutide for 10 weeks now — started at 1 mg and currently at 3.5 mg per week.
I’ve had the best experience with daily (ED) dosing, as it keeps the appetite suppression steady without noticeable highs or lows.


I’ll stay on Retatrutide until I reach about 5 mg per week, which should give me roughly a 20-week total Retatrutide cycle.
After a short break, I plan to try Cagrilintide next.


Has anyone here followed a similar approach?
What would be a good starting dose to balance lethargy and appetite.

 

[narta]

Reta is a glp-1/gip/glucagon agonist. Cagri is an amylin analog that can be used in conjunction with a glp-1 agonist. I would opt to use a lower dose of reta and add the cagri on top albeit on a low low dose of 125mcg

 

[xrayphoton13]

You don't take cagrilintide by itself. It's an add on to glp1s.

 

[Deadpool99]

I’ve been taking Retatrutide for 10 weeks now — started at 1 mg and currently at 3.5 mg per week.
I’ve had the best experience with daily (ED) dosing, as it keeps the appetite suppression steady without noticeable highs or lows.


I’ll stay on Retatrutide until I reach about 5 mg per week, which should give me roughly a 20-week total Retatrutide cycle.
After a short break, I plan to try Cagrilintide next.


Has anyone here followed a similar approach?
What would be a good starting dose to balance lethargy and appetite.

Try stacking cagri, many people I've noticed including me sometimes needs higher doses of cagri when reta isn't cutting it (pun intended). Also me and other usually notice cagri's food noise/appetite decreasing over time a little faster than reta. def can't be a standalone drug, not strong enough imo.

Ofc dosing/effectiveness is all individual, I started at 0.5 which is higher than many start with, some get away with 0.25-0.5mg and feel insane suppression, some don't respond.

In trials, to my knowledge, about 15–25 % were non-responders at low doses, and roughly half of them responded after escalation to 2.4–4.5 mg.

On paper it sounds very strong but in practice I haven't seen anyone use it long terms without eventually feeling it's effects decline rapidly. I'm at 4.5mg taking it slow on my 6th week on it. I have 5mg vials so eventually I'll just opt to trying stacking tirz or maybe increasing my reta

 

[Deadpool99]

I’ve been taking Retatrutide for 10 weeks now — started at 1 mg and currently at 3.5 mg per week.
I’ve had the best experience with daily (ED) dosing, as it keeps the appetite suppression steady without noticeable highs or lows.


I’ll stay on Retatrutide until I reach about 5 mg per week, which should give me roughly a 20-week total Retatrutide cycle.
After a short break, I plan to try Cagrilintide next.


Has anyone here followed a similar approach?
What would be a good starting dose to balance lethargy and appetite.

And honestly increasing reta is just has more benefits metabolically/fat burning wise/BG control wise and more cost effective IMO. At 8mg u see some great effects

 

[primojuju]

I prefer cagri by itself, has noticable mental hunger mitigation(food noise) but no slowing of the gut. I wouldn't start at more than .5mg a week. .3mg is where they started in the trials. I have rotated tirz, reta, and cagri using only one at a time to keep doses low and still keep losing weight. I have reached my goals and dont really use any of them anymore. But cagri is my favorite.

 

[ExxMarine]

Thank you for your feedback, experiences, and tips.
I will continue with Retatrutide until the effect/dosage reaches 5 mg per week and no other side effects are present.
After that, I’ll carefully introduce Cagrilintide on its own, starting at around 0.3 mg per week (≈ 45 µg ED), and observe what happens, increasing the dose if needed.
Later, I may also combine it with Retatrutide.
I prefer to test one compound at a time — including its ED (every-day) dosage.