Taking dantrolene on DNP cycle? Conciliator?

[GregR]

I just want to come out and say that this is so far just a thought and an idea I wanted to put out there from discussion. I do not know enough about the potential sides of dantrolene to assert that this is in any way a safe or smart thing to do. So treat this as a purely academic musing.

I've been doing some reading, it's mentioned numerous times how dantrolene has been incredibly effective at heading off acute dnp over dosing.

'By inhibiting calcium release from the sarcoplasmic reticulum, dantrolene reduces intracellular calcium. This is thought to help to facilitate heat dissipation in uncontrolled DNP-related hyperthermia. ' One of the factors in heat of dnp is the increase contractions brought about by elevated calcium.

Now, theoretically, could one run a higher dose of dnp whilst taking dantrolene for dnp cycles. Would doing this reduce DNP's efficiency? I don't think so, the DNP is still acting on the ATP, just preventing on the heating mechanisms - calcium incduced contractions - from occurring.

So this could mean standard doses could be run with even less sides with the same benefit. OR this means the envelope could be pushed harder with doses of dnp whilst keeping side effects bearable.

Could you imagine taking a gram of dnp for 10 days and feeling like it's half the dose?

Just a thought, I will keep reading and putting together more info, I was never one to read too much into the science of things, but I guess I ought to if I'm going to fuck around with this shit. As I've said, this is just an idea. I know dnp is amazing as it is and looking for ways to make it even more efficient is just getting greedy.

Thanks.

 

[bigrobbie]

I'm researching this bro....I'll get back to you ASAP with thoughts.

 

[Millard]

I just want to come out and say that this is so far just a thought and an idea I wanted to put out there from discussion. I do not know enough about the potential sides of dantrolene to assert that this is in any way a safe or smart thing to do. So treat this as a purely academic musing.

The only person that I've ever seen address the use of dantrolene in athletes is Dharkam:

Q: Can I stack DNP with PGF2 for better thermogenic response?

A: I would say no as I speculate that DNP thermogenic actions require the release of prostaglandins or at least employ similar pathways. To determine this for sure, scientists (do not try this at home) could use very high doses of aspirin a bit before DNP to determine whether the thermogenic response is affected. The same kind of result should be realized with Dantrolene as an inhibitor.

Read more: Dharkam's Way - The 'How-To" of PGF2

Dantrolene is an oral drug which belongs to a class of medication called calcium channel blockers [1]. Dantrolene is the most muscle specific member of this class. This is why it is so popular among athletes. It is commonly used as a muscle relaxant. As intracellular calcium release is responsible for muscle contractions, inhibition of this release induces a relaxation of the muscles. This reduces the muscle’s need for ATP, which allows a faster recovery of the training-induced diminution of the ATP “stores.” By inhibiting the calcium release from the sarcoplasmic reticulum, Dantrolene will impair the normal activation of the calpains by training.

Dantrolene has two major flaws. First, it acts on every muscle and not only specifically on the trained muscles as we would wish for optimal effects. Second, as a muscle relaxant, it will reduce muscle strength if you are not extra careful about the intake timing and dosage. What you want is for Dantrolene to produce its magic right after but not during the workout. If your training lasts less than one hour, you can take Dantrolene before your workout. This way, the drug will kick in at the right time. If you train for more than an hour, it is best to take Drantrolene in the middle of your workout. Start with the 25 mg tablets and build up SLOWLY to the 200 to 300 mg per day. It is ideal if you work out at night as Dantrolene will help you to sleep (it is a relaxant). If you have to drive or to perform something which requires attention while you are supposed to be under the influence of this drug, please do not take it. However most people work out in the evening, so it should not be a problem. If you have to drive home after your workout, take Drantrolene right after your workout so that it kicks in while you are home ready to go to bed.

Read more: Grow Even When Off Steroids! Part 2

 

[GregR]

Thanks guys.

After exhaustive googling I came across one dnp thread, 3 pages along, in which a guy asks the same question. This was the last post of the thread much to my frustration.

I am willing to give this a try. I am particularly prone to sweating and night issues on dnp, so maybe dantrolene late in the evening could make a huge difference.

 

[bigrobbie]

Thanks guys.

After exhaustive googling I came across one dnp thread, 3 pages along, in which a guy asks the same question. This was the last post of the thread much to my frustration.

I am willing to give this a try. I am particularly prone to sweating and night issues on dnp, so maybe dantrolene late in the evening could make a huge difference.

Use caution if you're set on DNP usage, PLEASE! Good luck bro!! Oh, I do worry about liver toxicity....keep an eye on that liver enzyeme baseline for spikes!

 

[GregR]

Use caution if you're set on DNP usage, PLEASE! Good luck bro!! Oh, I do worry about liver toxicity....keep an eye on that liver enzyeme baseline for spikes!

I've used DNP before. The issue was the puddle of water at night made sleep impossible.

If dantrolene can reduce the heat + knock me out at night then this would be of great benefit.

I would start at 50mg a day taken late in the evening, concurrent with 250mg of crystal. After a week, step it up to 100mg and 500mg dentro/dnp. If the fort is holding well at 100/500, then maybe up to 150/750 etc etc