MESO-Rx
Anabolic Steroids
Test shot every 5 days better than 1/week?
- Thread starter PointBlank
- Start date
frankwhardy
New Member
It sure seems to me that some individuals would benefit from a dosing interval of testosterone cypionate that is more frequent than every 7 days. If the idea is that the best compromise in terms of keeping a relatively stable blood level of T - while avoiding an excessive number of injections - might be obtained by having the injections correspond to the half-life of the drug, then it seems like it needs to be taken into consideration that the half-life is going to be different depending on the individual.
When Pfizer (formerly the Upjohn Co.) states here: http://www.pfizer.com/pfizer/download/uspi_depo_testosterone.pdf
that the half-life of Depo-Testosterone is approximately 8 days (for an IM injection), that doesn't mean that it's 8 days for everyone. That's an average. The reality, I'm sure, is that it is 8 days plus or minus several days depending on the individual. There are enormous differences in metabolic clearance rates among individuals.
I'm also finding a big drop off beginning about the 5th day as I'm doing 100mg T-cyp injections every 7 days. So I'm thinking that it would work better, and probably be healthier/safer too, to do 100mg every 5 days (the equivalent of 140mg/wk) versus uping the dose to, say, 150mg every 7 days. Why flood the body with that much T all at once, which will likely cause a greater increase in E2 and DHT levels, etc. (and expose the liver to a greater concentration of T) than presumably would a smaller more frequent dose?
Aside from having to do the injections on a different day each time, I just don't see any great inconvience from injecting (if you're self-injecting, that is) every 5 days compared to every 7 days. Any more thoughts on this subject?
When Pfizer (formerly the Upjohn Co.) states here: http://www.pfizer.com/pfizer/download/uspi_depo_testosterone.pdf
that the half-life of Depo-Testosterone is approximately 8 days (for an IM injection), that doesn't mean that it's 8 days for everyone. That's an average. The reality, I'm sure, is that it is 8 days plus or minus several days depending on the individual. There are enormous differences in metabolic clearance rates among individuals.
I'm also finding a big drop off beginning about the 5th day as I'm doing 100mg T-cyp injections every 7 days. So I'm thinking that it would work better, and probably be healthier/safer too, to do 100mg every 5 days (the equivalent of 140mg/wk) versus uping the dose to, say, 150mg every 7 days. Why flood the body with that much T all at once, which will likely cause a greater increase in E2 and DHT levels, etc. (and expose the liver to a greater concentration of T) than presumably would a smaller more frequent dose?
Aside from having to do the injections on a different day each time, I just don't see any great inconvience from injecting (if you're self-injecting, that is) every 5 days compared to every 7 days. Any more thoughts on this subject?
PointBlank
New Member
I have switched to doing one shot every 5 days, and feel better than 1/week, I am not experiencing a drop-off on day 5 and 6 like before. I would certainly rather do this than do 150mg 1/week, it must keep levels more even this way. FYI I am also using enanthate, which I think has a slightly shorter half-life than cypionate, so that could be a factor.
Axl
New Member
PointBlank said:
Great to hear I'm not the only one on enanthate here! Pointblanck: any chance you're from Europe? I got the impression all European endos prescribe enanthate and all American endos prescribe cypionate. I know both product are simular, but I think it's strange that for the same illness there are still two different types of T injections. I mean, there must be "an optimal product"...so it's either one or the other. Now which is it?
PointBlank
New Member
Axl said:Great to hear I'm not the only one on enanthate here! Pointblanck: any chance you're from Europe? I got the impression all European endos prescribe enanthate and all American endos prescribe cypionate. I know both product are simular, but I think it's strange that for the same illness there are still two different types of T injections. I mean, there must be "an optimal product"...so it's either one or the other. Now which is it?
I'm in New Zealand, haven't seen cypionate here at all, its either sustanon or enanthate.
Testosterone cypionate and testosterone enanthate are extremely similar and in practical terms, they are interchangeable. Cypionate happens to be more popular in North America while enanthate is more popular in the rest of the world.PointBlank said:
I'm not a fan of sustanon and I certainly don't recommend it for TRT, especially with enanthate is available.
PointBlank
New Member
mranak said:
Sustanon is nasty, no doubt. Most bodybuilders seem to like it but all those long-acting esters just hanging around and building up and up...yikes.
frankwhardy said:
This makes sense... but how/where would you work in your HcG protocol if you wanted to also do that (not only could you likely lower the Test Cyp IM shot levels (80mg???) but then there's also the testicle size factor for those who have experienced significant size reduction on TRT (and hope to regain it while on HcG) - and then there's simply the "feel good" aspect of HcG....
Larry
frankwhardy
New Member
Hi Larry,
Are you using Dr. C's HCG protocol by any chance? (I was just wondering if you had found that you were able to lower the T injection dosage from 100 to 80mg with the addition of the HCG.)
Under the injection every 5 days scenario, just as a guess, I was thinking the HCG (if necessary) might be used only once every 5 days - on either the day before or the day of the T injection. (Maybe I'll have the chance to do the experiment myself sometime in the future.) It might be a more beneficial use of the the HCG, though, to stick with the every 7 days regimen and allow a proportionately larger amount of T to come from the natural production the HCG induces over the 2 days it's used. There are a lot of permutations to think about and it doesn't help that each individual is different!
Frank
Are you using Dr. C's HCG protocol by any chance? (I was just wondering if you had found that you were able to lower the T injection dosage from 100 to 80mg with the addition of the HCG.)
Under the injection every 5 days scenario, just as a guess, I was thinking the HCG (if necessary) might be used only once every 5 days - on either the day before or the day of the T injection. (Maybe I'll have the chance to do the experiment myself sometime in the future.) It might be a more beneficial use of the the HCG, though, to stick with the every 7 days regimen and allow a proportionately larger amount of T to come from the natural production the HCG induces over the 2 days it's used. There are a lot of permutations to think about and it doesn't help that each individual is different!
Frank
Larry doing this did not work for me I felt better upping the dose to 150 mgs. every 7 days. You try sticking your leg every 5 days that was one of the things I did not like. For me I don't care what I use for TRT my E2 is going to need to be controlled so it is just better for me doing the higher dose. Doing shots every 5 days did not bring my levels up that much.
