Therapeutic doses of AAS for muscle injuries/knots

[hghlover]

I have a ton of build up muscle knots/trigger points/adhesions, whatever you want to call it. Build up from chronic overuse injuries. Making crunchy sounds when massaging the muscles. Stuff like massage, weight lifting, shockwave etc have not been able to touch it.

Nor has HGH, bpc 157 or tb4, although those peptides have been amazing at speeding the resistance training along, to the point where my PT asked me straight up if I was using peds.

Anyways, has anyone tried using AAS in lower therapeutic doses, say 100-200 mg deca and test, and noticed an improvement in these stubborn muscle knots, that a lot of us struggle with after injuries?

 

[Ghoul]

I haven't heard of AAS helping with that.

If ibuprofen makes you feel better I'd attack systemic inflammation first, and go with supplements that improve nerve conduction to minimize cramping, as that's probably a part of the problem too.

 

[hghlover]

I haven't heard of AAS helping with that.

If ibuprofen makes you feel better I'd attack systemic inflammation first, and go with supplements that improve nerve conduction to minimize cramping, as that's probably a part of the problem too.

Intresting, thanks!

Already on stuff like cucurmin and ginger supps for systemic inflammation. Thymosin beta 4 too for that matter.

I never viewed it from the nerve conduction point of view before. I'll look into that. Any supplements in particular you would recommend for nerve conduction?

 

[Ghoul]

Intresting, thanks! I never viewed it from the nerve conduction point of view before. I'll look into that.

When there's an issue affecting multiple areas with the same effects, the cause is usually systemic. With muscles there's often a self-feeding vicious cycle that's has to be broken.

Like inflammation from an injury leading to fibers sticking together reducing blood flow, inducing cramps, that cause pain and stress boosting systemic inflammation etc,

Taurine and magnesium are very effective at reducing cramps. I had them for years, and wasn't a big believer in supplements but these two things made a night and day difference.

Systemic inflammation is a tougher nut to crack, but as is becoming increasingly obvious. GLP class drugs are very good at reducing systemic inflammation. The problem if you don't want to lose weight is getting enough without killing your appetite. Tirz is probably better in this regard than Sema,

The body has sensory fibers in the vagus nerve that detect signs of bacterial infection, and signal the brain to increase inflammation everywhere to be a "cocked gun" ready to fight off invaders. This nerve can become hypersensitive, causing unnecessary inflammation throughout the body. GLPs "turn down" this sensitivity reducing inflammation everywhere.

Like being on a high dose of ibuprofen continuously, without the harmful effects of that drug.

 

[hghlover]

When there an issue affecting multiple areas with the same effects, the cause is usually systemic. With muscles there's often a self-feeding vicious cycle that's has to be broken.

Like inflammation from an injury leading to fibers sticking together reducing blood flow, inducing cramps, that cause pain and stress boosting systemic inflammation etc,

Taurine and magnesium are very effective at reducing cramps. I had them for years, and wasn't a big believer in supplements but these two things made a night and day difference.

Systemic inflammation is a tougher nut to crack, but as is becoming increasingly obvious. GLP class drugs are very good at reducing systemic inflammation. The problem if you don't want to lose weight is getting enough without killing your appetite. Tirz is probably better in this regard than Sema,

The body has sensory fibers in the vagus nerve that detect signs of bacterial infection, and signal the brain to increase inflammation everywhere to be a "cocked gun" ready to fight off invaders. This nerve can become hypersensitive, causing unnecessary inflammation throughout the body. GLPs "turn down" this sensitivity reducing inflammation everywhere.

Like being on a high dose of ibuprofen continuously, without the harmful effects of that drug.

It makes a lot of sense. Thanks, much appreciated. I'll have a look at those supplements. Fingers crossed.

 

[AlexDavis43]

Already on stuff like cucurmin and ginger supps for systemic inflammation. Thymosin beta 4 too for that matter.

If you have excess body fat, look into getting rid of that before piling on more drugs supplements etc

Macrophages in adipose tissue spew out pro-inflammatory cytokines. Solution is fat loss.

 

[hghlover]

When there's an issue affecting multiple areas with the same effects, the cause is usually systemic. With muscles there's often a self-feeding vicious cycle that's has to be broken.

Like inflammation from an injury leading to fibers sticking together reducing blood flow, inducing cramps, that cause pain and stress boosting systemic inflammation etc,

Taurine and magnesium are very effective at reducing cramps. I had them for years, and wasn't a big believer in supplements but these two things made a night and day difference.

Systemic inflammation is a tougher nut to crack, but as is becoming increasingly obvious. GLP class drugs are very good at reducing systemic inflammation. The problem if you don't want to lose weight is getting enough without killing your appetite. Tirz is probably better in this regard than Sema,

The body has sensory fibers in the vagus nerve that detect signs of bacterial infection, and signal the brain to increase inflammation everywhere to be a "cocked gun" ready to fight off invaders. This nerve can become hypersensitive, causing unnecessary inflammation throughout the body. GLPs "turn down" this sensitivity reducing inflammation everywhere.

Like being on a high dose of ibuprofen continuously, without the harmful effects of that drug.

I'll hit you with a few question, I hope that's okay.

Taurin and magnesium, what daily doses are you running/would recommend for muscles?

I'm possibly looking at semaglutide, although tirzepatide could work aswell. What dose range daily/weekly would you recommend for lowering chronic inflammation with these compounds?

Lastly, I'm already running metformin and berberine for managing blood glucose on 4 iu hgh. It keeps my fasted blood glucose stable at 5.3. Any issues being on these meds in combination with a glp-1 compound?

Thank you!

 

[Ghoul]

I'll hit you with a few question, I hope that's okay.

Taurin and magnesium, what daily doses are you running/would recommend for muscles?

I'm possibly looking at semaglutide, although tirzepatide could work aswell. What dose range daily/weekly would you recommend for lowering chronic inflammation with these compounds?

Lastly, I'm already running metformin and berberine for managing blood glucose on 4 iu hgh. It keeps my fasted blood glucose stable at 5.3. Any issues being on these meds in combination with a glp-1 compound?

Thank you!

Are you at ideal weight, or would some degree of appetite suppression be acceptable?

 

[hghlover]

Are you at ideal weight, or would some degree of appetite suppression be acceptable?

I am perhaps 5 kg overweight but am not looking to cut at the moment. I don't want to tank my IGF 1 by being in a deficit while recovering from injuries. I am counting all my calories and am pretty disciplined doing that.

In terms of a glp-1 compound, my main concern is going with the one being most effective lowering chronic inflammation. Any appetite suppression I'll deal with.

Obviously, any fat loss outside a caloric deficit is welcome.

 

[Ghoul]

I am perhaps 5 kg overweight but am not looking to cut at the moment. I don't want to tank my IGF 1 by being in a deficit while recovering from injuries. I am counting all my calories and am pretty disciplined doing that.

In terms of a glp-1 compound, my main concern is going with the one being most effective lowering chronic inflammation. Any appetite suppression I'll deal with.

Obviously, any fat loss outside a caloric deficit is welcome.

Tirz is the better option in your situation. It's entirely possible (common even) to take 2.5mg(or more) and feel no side effects or even appetite reduction, while the anti-inflammatory benefits are still provided. That's much harder to pull off with Sema. By the time you take enough Sema for significant anti-inflammatory effects, you'll likely experience strong appetite suppression and sides.

Since you monitor glucose, you can decide if you want to drop the metformin as it may no longer be necessary when using a GLP, but they are safe to use together.

The usual dose of Taurine is 2g/day. This is also the dose shown to significantly reduce cramping in people with liver disease (who have chronic Taurine deficiencies since the liver is where Taurine is stored). It stabilizes muscle cell walls making them less prone to cramps. I dropped to 1g/day and it's effective for me. More is safe, maxing at 10mg/day, but I see little benefit in studies beyond 2mg.

The usual dose of Magnesium is 200mg/day. 400mg/day max safe level. I take 100mg/day. Be aware it can act as a laxative at higher doses, so reduce dose if that happens. Glycinate is the best form for easy absorption.

I take both in the morning. Taurine is very inexpensive in powder form, as a tasteless, easily dissolving crystal, but capsules are available too.

 

[hghlover]

Tirz is the better option in your situation. It's entirely possible (common even) to take 2.5mg(or more) and feel no side effects or even appetite reduction, while the anti-inflammatory benefits are still provided. That's much harder to pull off with Sema. By the time you take enough Sema for significant anti-inflammatory effects, you'll likely experience strong appetite suppression and sides.

Since you monitor glucose, you can decide if you want to drop the metformin as it may no longer be necessary when using a GLP, but they are safe to use together.

The usual dose of Taurine is 2g/day. This is also the dose shown to significantly reduce cramping in people with liver disease (who have chronic Taurine deficiencies since the liver is where Taurine is stored). It stabilizes muscle cell walls making them less prone to cramps. I dropped to 1g/day and it's effective for me. More is safe, maxing at 10mg/day, but I see little benefit in studies beyond 2mg.

The usual dose of Magnesium is 200mg/day. 400mg/day max safe level. I take 100mg/day. Be aware it can act as a laxative at higher doses, so reduce dose if that happens. Glycinate is the best form for easy absorption.

I take both in the morning. Taurine is very inexpensive in powder form, as a tasteless, easily dissolving crystal, but capsules are available too.

Absolutely well written perfect answer. Thank you buddy! Much appreciated.

 

[Ghoul]

Absolutely well written perfect answer. Thank you buddy! Much appreciated.

Let me add, while the anti-cramping effects of Taurine are well documented in scientific research, you mentioned "muscle overuse", the damage of which Taurine also seems to reverse. It's good stuff, and while I'd rather get it from eating lots of steak, I'm happy I started using it:

Frontiers | Taurine Reverses Oxidative Damages and Restores the Muscle Function in Overuse of Exercised Muscle

Exercise-induced oxidative stress is linked with the expression level of endogenous antioxidants, but these antioxidants cannot overcome all oxidative stress...

www.frontiersin.org

 

[hghlover]

Let me add, while the anti-cramping effects of Taurine are well documented in scientific research, you mentioned "muscle overuse", the damage of which Taurine also seems to reverse. It's good stuff, and while I'd rather get it from eating lots of steak, I'm happy I started using it:

Frontiers | Taurine Reverses Oxidative Damages and Restores the Muscle Function in Overuse of Exercised Muscle

Exercise-induced oxidative stress is linked with the expression level of endogenous antioxidants, but these antioxidants cannot overcome all oxidative stress...

www.frontiersin.org

Intresting. Yeah I'll definitely try adding the powder to my daily stack. May aswell.

 

[hghlover]

@Ghoul Hey bud, just following up. I've added both magnesium and taurine to my daily stack.

This might be a tough one to answer. In regards to tirzepatide, do you think working oneself up to 5 mg weekly is ideal, for reaching sufficient systemic anti-inflammatory effects, or is 2.5 mg weekly more than enough? Thanks

 

[Ghoul]

@Ghoul Hey bud, just following up. I've added both magnesium and taurine to my daily stack.

This might be a tough one to answer. In regards to tirzepatide, do you think working oneself up to 5 mg weekly is ideal, for reaching sufficient systemic anti-inflammatory effects, or is 2.5 mg weekly more than enough? Thanks

Any amount will provide a benefit, but the higher you can get without inducing too much appetite suppression the greater the degree of inflammation reduction.

 

[hghlover]

Any amount will provide a benefit, but the higher you can get without inducing too much appetite suppression the greater the degree of inflammation reduction.

Gotcha, thanks

 

[hghlover]

Any amount will provide a benefit, but the higher you can get without inducing too much appetite suppression the greater the degree of inflammation reduction.

Oh by the way, I'm reading some mixed opinions. Do you know how long tirzepatide is good for before degrading? As a lyophilized powder in a vial, stored in the fridge, both before and after being mixed with bac water?

 

[Sampei]

Oh by the way, I'm reading some mixed opinions. Do you know how long tirzepatide is good for before degrading? As a lyophilized powder in a vial, stored in the fridge, both before and after being mixed with bac water?

A very long time.

 

[Ghoul]

Oh by the way, I'm reading some mixed opinions. Do you know how long tirzepatide is good for before degrading? As a lyophilized powder in a vial, stored in the fridge, both before and after being mixed with bac water?

Impossible to say with any certainty, There are too many variables, and every batch will have differences as well.

But generally:

Keep cold and out of light for less degradation.

Longer lyophilized than reconstituted.

Longer when reconstituted to a higher dilution (ideally, .5ml per dose. )

Longer when reconstituted with pharma grade BAC vs UGL.

 

[hghlover]

A very long time.

Are we talking years before mixed with water?