MESO-Rx
Anabolic Steroids
Trenbolone while on tirzepatide
- Thread starter sliderke
- Start date
JuiceJohn
Member
That’s a really interesting combo to think about, especially since both compounds mess with nutrient handling in different ways.
Tren definitely increases calorie expenditure — it’s known for revving up your metabolism, body temp, and nutrient partitioning. You’ll feel hungrier on it (usually), and it can make staying in a deficit a lot harder mentally.
Tirzepatide, on the other hand, blunts appetite hard and increases insulin sensitivity — so pairing that with even low-dose Tren could create a situation where you’re burning more but eating way less, which might push you toward hypo if carbs are too low or if you're training fasted.
I haven’t seen much real-world data on that combo yet, but I’d imagine it could be pretty harsh without enough dietary control, especially if you’re using other glucose-lowering agents (like GH or insulin).
Definitely one of those “advanced user only” setups — but super interesting to think about. Anyone here actually tried it?
Tren definitely increases calorie expenditure — it’s known for revving up your metabolism, body temp, and nutrient partitioning. You’ll feel hungrier on it (usually), and it can make staying in a deficit a lot harder mentally.
Tirzepatide, on the other hand, blunts appetite hard and increases insulin sensitivity — so pairing that with even low-dose Tren could create a situation where you’re burning more but eating way less, which might push you toward hypo if carbs are too low or if you're training fasted.
I haven’t seen much real-world data on that combo yet, but I’d imagine it could be pretty harsh without enough dietary control, especially if you’re using other glucose-lowering agents (like GH or insulin).
Definitely one of those “advanced user only” setups — but super interesting to think about. Anyone here actually tried it?
xrayphoton13
Member
The first few days after I started tren I felt a little hypo during my workout but then it was gone. 10mg tirzepatide, 250mg tren e
It does what it's supposed to yes.
I won't be using tirzepatide nor semaglutide again though because it totally fucks up my stomach.
xrayphoton13
Member
Tirz really kicks my ass if I overeat and that's actually part of the reason I like it. Keeps me from overeating or I'll suffer with bloating, gas, and sulfur burps.
I tried reta from qsc and xyx for two months now at 8mg and don't notice anything so I probably won't use it again. No food noise suppression whatsoever, just an elevated heart and mines already elevated enough from test, caffeine, and ephedrine or clen so no thank you. I understand it works wonders for some but I'm not noticing any benefits over tirz to be honest. Maybe not as lethargic but that's it. Just gotta find what works for you
Dirthand
Member
I think thay would be the reason you have a solid laid out diet plan that consist of timing your meals with certain macros at certain times of the day. In my personal experience tren worked well for a body recomp.. ran it all last year while taking tirizepitide.. no problems. Great progress.
Good to know. Thnx
explodingHeart
Member
god damn bro
Both sema and tirz make me swing between constipation and diarrhoea, and a few times I had to go to the hospital with really bad stomach pain from what turned out to be basically gas. I think the delayed gastric emptying hits me really hard with these compounds, and that’s what ends up causing me problems. I’ve tried even with 1mg tirzepatide, after a few weeks my stomach is in bits. I just lived with it for 9 months last year but eventually decided that the juice isn’t worth the squeeze for me. For insulin sensitivity I need to rely on good old cardio and GDAs. And in terms of hunger when cutting, I just have to live with it unfortunately.
Maybe if reta gets approved then I’ll try that, but the increased heart rate puts me off to be honest.
xrayphoton13
Member
Yeah mine was mid to high 50s before trt. Jumped to the high 60s on trt. Jumped to low 70s on tirz. Jumped to high 70s with HGH. Jumped to low 80s with trt/HGH/reta. This is with regular weight training and cardio even. I wonder how much just cutting out the 200mg caffeine 2x a day would help. I think the big jump with trt is because I'm prescribed the cream and it has a very short half life (apply 2x/day) and converts highly to dht
Mrhairyman
Member
I have thought about using tren while on tirz, but the first thing that came to mind is " stomach issues X10 "
I get heartburn and acid relx if I use tren past 2 weeks, I can only imagine what it would do to me on tirz.
I have opped for inject-able anadrol and Dbol instead, I get "close" to the same aggression and strength gains in the gym minus the 24/7 pump/size
I’ve used that combo a few times. In fact, I’ve used tren with Sema, Tirzepatide and Retatrutide. You will get totally shredded. That was my experience and I’m over 40. I’m sure you will love it too.
I used tren at 300-350mg while on the max Reta dosage with no issues whatsoever.
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