TRIZ REACTION HELP

[gotgrowth]

Been using triz for 4-5 weeks still at low dose. Around 4mg. Last 2 shots I’ve been getting itchy red welts. That take pretty much a week to go away. 30mg reconstituted with 3ml bac water.

I don’t remember it i was getting them at 2mg or not but i guess now because more volume it’s more pronounced

Been trying benedryl gel and oral benedryl doesn’t seem to help

It’s from a well know Chinese source

- my BAC is good
- tired letting the solution get to room temp. - tried making sure the area was dry from alcohol before pinning.
- Made sure I’m getting deep sub q.

I know the Triz is working But this sucks
Help!

 

[RockyP]

Been using triz for 4-5 weeks still at low dose. Around 4mg. Last 2 shots I’ve been getting itchy red welts. That take pretty much a week to go away. 30mg reconstituted with 3ml bac water.

I don’t remember it i was getting them at 2mg or not but i guess now because more volume it’s more pronounced

Been trying benedryl gel and oral benedryl doesn’t seem to help

It’s from a well know Chinese source

- my BAC is good
- tired letting the solution get to room temp. - tried making sure the area was dry from alcohol before pinning.
- Made sure I’m getting deep sub q.

I know the Triz is working But this sucks
Help!

May need to try a different source. I had some similar irritation from a glutathione preparation. Switched brands and went away.

 

[Ghoul]

What's the volume of the injection?

How do you know you're BAC is good?

 

[wells14]

That sounds pretty bad. Are you administering 4mg once weekly or in split doses? If you didn't get the irritation/reaction from a 2mg dose, you could try continuing with 2mg doses but twice weekly. I dose reta EoD as I don't like pinning large volumes subQ and its working totally fine.

 

[gotgrowth]

Well the expiration isn’t for another several months it’s pharm grade 3.5-40 units

What's the volume of the injection?

How do you know you're BAC is good?

 

[BigDadd7]

What's the volume of the injection?

How do you know you're BAC is good?

From his math, .4 ml

 

[sionnach]

Been using triz for 4-5 weeks still at low dose. Around 4mg. Last 2 shots I’ve been getting itchy red welts. That take pretty much a week to go away. 30mg reconstituted with 3ml bac water.

I don’t remember it i was getting them at 2mg or not but i guess now because more volume it’s more pronounced

Been trying benedryl gel and oral benedryl doesn’t seem to help

It’s from a well know Chinese source

- my BAC is good
- tired letting the solution get to room temp. - tried making sure the area was dry from alcohol before pinning.
- Made sure I’m getting deep sub q.

I know the Triz is working But this sucks
Help!

One user from another forum had the same reaction. Culprit ended up being previously frozen Hospira (dunno how that would change composition, but switching to fresh Hospira solved the issue). What brand BAC are you using?

Could be product degradation from poor storage.

Could be you developed an allergy to mannitol. Confirm other ingredients with your seller.

Could be cap disintegration. I've had multiple Chinese batches with shitty rubber seals.

 

[Ghoul]

From his math, .4 ml

Ah yeah thx lol, was distracted reading that.

So weeks 1-3 ok, then reaction weeks 4-5.

Pretty good chance of aggregate formation over the course of a month, potentially causing site reactions.

If it doesn't happen with a fresh vial you've got your answer.

 

[gotgrowth]

Ah yeah thx lol, was distracted reading that.

So weeks 1-3 ok, then reaction weeks 4-5.

Pretty good chance of aggregate formation over the course of a month, potentially causing site reactions.

If it doesn't happen with a fresh vial you've got your answer.

I threw out my first bottle because it was left out and this bottle is about 2-3 weeks old so i should try another bottle ? First if not buy different bac ?

 

[gotgrowth]

Ah yeah thx lol, was distracted reading that.

So weeks 1-3 ok, then reaction weeks 4-5.

Pretty good chance of aggregate formation over the course of a month, potentially causing site reactions.

If it doesn't happen with a fresh vial you've got your answer.

I sent you a message

 

[sionnach]

I threw out my first bottle because it was left out and this bottle is about 2-3 weeks old so i should try another bottle ? First if not buy different bac ?

If your BAC isn't Pfizer (you still haven't said) then chunk it. Too many bad stories about Chinese and domestic reseller water. You can make your own, but unless you've got mad lab experience, don't try it.

 

[gotgrowth]

If your BAC isn't Pfizer (you still haven't said) then chunk it. Too many bad stories about Chinese and domestic reseller water. You can make your own, but unless you've got mad lab experience, don't try it.

 

[sionnach]

Hospira

Perfect. I'd move that down the list as possibilities then. It's likely some lyophilization additive in that specific batch of tirz, or as @readalot likes to say "excipients".

 

[gotgrowth]

Hospira

Perfect. I'd move that down the list as possibilities then. It's likely some lyophilization additive in that specific batch of tirz, or as @readalot likes to say "excipients".

I’m wondering if i should just pin straight bac and make sure it’s good. And then maybe try filtering my stuff

 

[sionnach]

I’m wondering if i should just pin straight bac and make sure it’s good. And then maybe try filtering my stuff

Never a bad idea as a scientist to start small with your troubleshooting checklist.

 

[sliderke]

You got eu link for this bac water?

 

[gotgrowth]

Never a bad idea as a scientist to start small with your troubleshooting checklist.

As an update i just started again and filtered my triz this time around and still red welts

I tried the bad straight and it’s good

 

[sionnach]

As an update i just started again and filtered my triz this time around and still red welts

I tried the bad straight and it’s good

 

[psauce]

One user from another forum had the same reaction. Culprit ended up being previously frozen Hospira (dunno how that would change composition, but switching to fresh Hospira solved the issue).

Freezing isn't the problem, per se, it's the concentration of dissolved stuff that happens during freezing.

The really short version is that freezing is when two molecules of a liquid have an intermolecular attraction that's stronger than the motion due to heat lets them break. When that initial crystal forms, the other water (that's also not moving quickly) will eventually bump into it and get locked in.

When you have solutes dissolved in water, the formation of ice crystals essentially pulls liquid away and concentrates the remaining solution. If a peptide has a hydrophobic domain, and you get them close enough to have frequent collisions, they'll match up and make an aggregate, which is irreversible even upon heating because it's a thermodynamically favorable configuration.

Freeze drying gets around this and makes a pretty stable product. Flash freezing, like in LN2, can also work to varying degrees, but you gotta keep everything super cold which is often impractical to impossible.

 

[gotgrowth]

Freezing isn't the problem, per se, it's the concentration of dissolved stuff that happens during freezing.

The really short version is that freezing is when two molecules of a liquid have an intermolecular attraction that's stronger than the motion due to heat lets them break. When that initial crystal forms, the other water (that's also not moving quickly) will eventually bump into it and get locked in.

When you have solutes dissolved in water, the formation of ice crystals essentially pulls liquid away and concentrates the remaining solution. If a peptide has a hydrophobic domain, and you get them close enough to have frequent collisions, they'll match up and make an aggregate, which is irreversible even upon heating because it's a thermodynamically favorable configuration.

Freeze drying gets around this and makes a pretty stable product. Flash freezing, like in LN2, can also work to varying degrees, but you gotta keep everything super cold which is often impractical to impossible.

I shot straight bac and was fine