Which steroids alter thyroid hormone? Or what could cause an idiopathic increase in T3 (almost doubled since last blood test)

[MFAAS]

I got blood after my recent cycle, been off for like 2 months now.

Currently running 160 mg TRT weekly along with 4 IU HGH daily timed as per suggestion of Type-IIx, during a meal about 2.5-3 hours before workout.

My T is back to normal, everything seems fine except one really weird thing is that my

Free T3, which had never really changed before, is now high. It's at 4.6 (range 2.3-4.2) pg/mL. Previously Free T3 was at 2.8.

Free T4 is normal.
T3 Uptake is high at 37% (range 22-35%) - previously was 30%
Total T4 and TSH are both normal, although total T4 is on the lower end of normal. previously TSH was slightly high at 5 (0.4,-4.5 range).

I'm just trying to figure out what might be going on. I was fasted for the blood test. I have had issues with appetite recently not being able to eat enough. In probably barely at many maint as in not really losing weight m, maybe very slowly losing some fat and leaning out more. I haven't had any additional anxiety or fast heartbeat, no sign of goiter. It's the weirdest thing.

Lastly, my white blood cell count is a little low. But I feel totally fine. Definitely don't feel like I'm sick or fighting anything off.

I haven't taken anything that I know of that would effect the thyroid.

All the steps I've taken in the last 6 months:

- MENT (stopped over 3 months ago i think)
- mast P
- test C
- NPP
- DHB
- anavar
- injectable superdrol - just a couple times, experimenting with it for use in a future cycle
- HGH

I have been sleeping much better but I can't see how that would nearly double my free t3.

Any ideas?

Thank you meso brothers and sisters!

 

[Alphalfa]

rHGH is well known for increasing/improving T4 conversion to T3.

 

[MFAAS]

rHGH is well known for increasing/improving T4 conversion to T3.

Oh duh I can't believe I forgot that. All I could recall was anecdotal tren effects and that just stopped any other thoughts from getting through lol. Makes sense now.

 

[Alphalfa]

Oh duh I can't believe I forgot that. All I could recall was anecdotal tren effects and that just stopped any other thoughts from getting through lol. Makes sense now.

Well, tren is supposed to decrease T3, it worked that way for me as well.

But might occur an increase of Free T3 due to the effect of hard androgens like tren, or orals, decreasing binding globulins, TBG in this case, increasing the Free fraction of T3.

 

[Type-IIx]

@Alphalfa is correct: rhGH has this effect by increasing peripheral T4 to T3 conversion & there is some evidence of androgens reducing TBG (e.g., FTM transition)... These effects can combine to increase fT3. There's no clear dose-dependency of androgens lowering TBG, but a notable effect in replacement of high endogenous estrogens with high endogenous T in XX females identifying as men.

 

[MFAAS]

Well, tren is supposed to decrease T3, it worked that way for me as well.

But might occur an increase of Free T3 due to the effect of hard androgens like tren, or orals, decreasing binding globulins, TBG in this case, increasing the Free fraction of T3.

Yeah I can't stand tren so it's been a while since I've looked into those anecdotes at all. Now it's coming back to me.

@Alphalfa is correct: rhGH has this effect by increasing peripheral T4 to T3 conversion & there is some evidence of androgens reducing TBG (e.g., FTM transition)... These effects can combine to increase fT3. There's no clear dose-dependency of androgens lowering TBG, but a notable effect in replacement of high endogenous estrogens with high endogenous T in XX females identifying as men.

How much would one expect 25 mcg of T3 to increase FT3 blood levels? I'm just curious what the difference in magnitude of effect might be between HGH increase in FT3 and exogenous T3. I don't believe I have ever seen before/after bloods for someone kn T3

 

[Type-IIx]

Yeah I can't stand tren so it's been a while since I've looked into those anecdotes at all. Now it's coming back to me.

How much would one expect 25 mcg of T3 to increase FT3 blood levels? I'm just curious what the difference in magnitude of effect might be between HGH increase in FT3 and exogenous T3. I don't believe I have ever seen before/after bloods for someone kn T3

25 µg Cytomel is a replacement dose, so I wouldn't expect it to increase fT3 blood levels. For a 75 µg Cytomel dose, fT3 increases by 1.7-fold (mean).