Here2Learn
Member
Just got this from Trust Pointe saying there are widespread issues with Tirz quality.
MESO-Rx
Anabolic Steroids
Wide spread Tirz issues
- Thread starter Here2Learn
- Start date
Ghoul
Member
Thanks for sharing this. God bless these small labs giving us some insight into our peptides, but we need to also keep in mind they don't have the same capacity to dive into all the details a major biotech lab with tens of millions of dollars worth of equipment and an army of personal have.
If *they*, the small labs, find quality problems, it's likely even worse than that.
This is a decent glimpse, at a reasonable cost, but there's far more we don't see, which becomes apparent when you look at the results of something like peptide mapping and impurity characterization. An extremely expensive and time consuming process the pharma companies have to use to meet the safety and quality requirements imposed on them by regulators.
If *they*, the small labs, find quality problems, it's likely even worse than that.
This is a decent glimpse, at a reasonable cost, but there's far more we don't see, which becomes apparent when you look at the results of something like peptide mapping and impurity characterization. An extremely expensive and time consuming process the pharma companies have to use to meet the safety and quality requirements imposed on them by regulators.
Here2Learn
Member
I think it is great they wanted to get this information out to everyone. I never compare pharma to grey, they are just not the same and never will be.
I am curious how so many Tirz testings have come back clean that are being posted. Makes me wonder why we have not seen more bad reports coming back and if we haven’t how they are covering that up. I get vendors posting fake reports but people that are supposedly customers who have sent theirs off haven’t posted issues.
I am curious how so many Tirz testings have come back clean that are being posted. Makes me wonder why we have not seen more bad reports coming back and if we haven’t how they are covering that up. I get vendors posting fake reports but people that are supposedly customers who have sent theirs off haven’t posted issues.
Ghoul
Member
Well most vendors here also seemed to dodge the "no peptide" scandal that affected many outside of Meso. Maybe the vendors who sell AAS are just coincidentally connected to a different network of peptide suppliers.
Regardless, once again we're reminded of the fact we can never truly know what's in a particular vial, and who knows what other things "bad batches" include. I think a lot of folks write off the "not peptide" impurities as some harmless vitamin B12 floating around the vial, or degraded peptide turns into something benign, when nothing could be farther from the truth.
USP / FDA have stringent requirements regarding identifying all this unwanted crap, manufacturing residues and degraded peptide, using computer modeling to determine which present a health risk (in silico testing), and ensuring they be removed or prevented from forming at all. They're called "Critical impurities", and even the slightest change to peptide manufacturing, storing, or packaging requires reassessment to see if any new types are created as a result,
Think UGL is doing this?
At least filtering reduces this risk.
AlexDavis43
Member
They said "sub-99%" purity which could mean 98% purity, well within pharma and UGL range.
I don't understand the point of that article. Fearmongering? Are they really finding 80% tirz samples, for example, which would be an actual cause for concern.
I don't understand the point of that article. Fearmongering? Are they really finding 80% tirz samples, for example, which would be an actual cause for concern.
Here2Learn
Member
There has been a ton of 0% Tirz delivered in the last month. I would imagine that is what they are referencing.
AlexDavis43
Member
That's messed up. Have they reported any 100% tirz samples?
surely they posted some positive controls
Spaceman Spiff
Subscriber
What 0% tirz?
PiscesMoon
Member
GYC shipping vials with zero peptides detected
From the scattered info between the GYC server and the Swiss server, T40 from gb 9, and maybe gb 11, have zero tirz detected. The attached is from customer test
glp1forum.com
Here2Learn
Member
There are three known companies so far, I don’t buy Tirz so I haven’t tracked all the updates but I’ve seen a ton of posts on other forums.
Spaceman Spiff
Subscriber
I just haven't seen anything of 0% tirz
AlexDavis43
Member
You mean from Jano. Piscesmoon posted something from Peptide Test™
I still have questions about Here2Learn's reply from Trust Pointe, with their potentially fearmongering headline "Widespread Tirz with <99% Purity."
They only posted one negative result with about their testing method. No positive controls, no pharma tirz to compare and verify their testing capacity. Just vague.
Ghoul
Member
You see "fearmongering" conspiracies everywhere.
PiscesMoon
Member
RE: 0mg Tirzepatide (and other 0mg peptides)
glp1forum.com
Recommended reading to check out the thread I linked. If one has the time and patience to spare.
@Ghoul @Spaceman Spiff @AlexDavis43 @Here2Learn
There is some incredible mental gymnastics and general acrobatics happening as the whole alleged scandal unfurls. At some points the lines of reasoning, the suspicions, and the conclusions all reeeeally push the limits of believability. Like it feels majorly Looney Tunes, the lengths gone to """figure out""" what happened.
The drama overall seems like a weird distraction, or some strange way of creating confusion and exhausting attention. "idk" though. That is all just my subjective* opinion as an outsider to the situation.
edit: I do believe it is worth considering, and reading to learn more, because it seems to involve some crossover with vendors who may be present on MESO-Rx , as well as a testing lab that is used often enough for peptide tests.
GYC shipping vials with zero peptides detected
From the scattered info between the GYC server and the Swiss server, T40 from gb 9, and maybe gb 11, have zero tirz detected. The attached is from customer test
glp1forum.com
Recommended reading to check out the thread I linked. If one has the time and patience to spare.
@Ghoul @Spaceman Spiff @AlexDavis43 @Here2LearnThere is some incredible mental gymnastics and general acrobatics happening as the whole alleged scandal unfurls. At some points the lines of reasoning, the suspicions, and the conclusions all reeeeally push the limits of believability. Like it feels majorly Looney Tunes, the lengths gone to """figure out""" what happened.
The drama overall seems like a weird distraction, or some strange way of creating confusion and exhausting attention. "idk" though. That is all just my subjective* opinion as an outsider to the situation.
edit: I do believe it is worth considering, and reading to learn more, because it seems to involve some crossover with vendors who may be present on MESO-Rx , as well as a testing lab that is used often enough for peptide tests.
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AlexDavis43
Member
You fearmonger everywhere.
OldGHGuy
Member
I really hope Trustpointe wouldn't call a substance that tested at 0% Tirz as a "<99% Tirz" substance. Although technically true, they are two very different things.
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Here2Learn
Member
I think there are two different things happening. One, there was Tirz shipped with 0% and second there is fast degrading Tirz. Now did the fast degrading become the same zero latter? No clue.
AlexDavis43
Member
Their post was really vague. The title, misleading. I can't figure why they'd post that article.
SpicyMeatball
Member
It’s because it’s nothing more than an advertisement for this lab
Ghoul
Member
Jeezus Christ, first, this was an email to their existing clients, not an "article" or a marketing email. See the "Mailchimp" URL and the "unsubscribe" buttons?
It's not vague at all.
"We've had a lot of poor Tirz results lately. To ensure it's not our process, here are the chromatographs of a blank sample, the reference standard Tirz sample with the expected result, and one of the samples that was below 99%, showing a clear peak of impurity. We think the common element is a batch of degraded API coming from the same manufacturer. If you would like us to discuss test results with your supplier we'd be happy to."
This is not difficult to understand.
The 0% peptide issue affected numerous peptides from several different vendors, all getting ripped off by the same source and unrelated to this.
