Introductory Physiology and Pharmacology of Androgens Endogenous androgens are well known for their many functions in promoting sexual differentiation and the induction of the male phenotype. In the male, the two endogenous androgens most active in promoting these effects are testosterone (T) and dihydroxytestosterone (DHT). T is the most quantitatively important androgen in systemic circulation […]
androgen receptor
Androgen Receptors Downregulate Don’t They? Part 2
In part 1 of this article we discussed the mistake of thinking about androgen receptors (testosterone receptors) in the same way we think of other receptors such as beta-receptors. Beta-receptors down regulate in response to beta-adrenergic stimulation whereas there is good evidence that androgen receptors increase in numbers in response to androgens. We also discussed […]
Androgen Receptors Downregulate Don’t They? Part 1
There is as much misinformation about steroids as there is good information had among bodybuilding enthusiasts. Go to any gym and you will hear some kid spouting off to his buddies about how steroids do this, or how they do that, or whatever. This soon starts somewhat of a pissing contest (excuse the expression) as […]