Tb500 and my calf

[Joeblack]

Hurt my calf ( the Soleus )

After hard cardio or long walking it hurt and almost to a point of a limp.

Going to run tb500 2mg 2x a week

pretty much a log to remember to take my shoots

8/28 took 2mg Subq

calf hurts dues to 40 mins walking at 2.8 mph

 

[Dr JIM]

Gosh don't you think it would be optimal to have a formal diagnosis? Yep, bc that's the only way of establishing (or approximating if preferred) what the recovery interval would be absent the use of TB-500.

 

[Joeblack]

Gosh don't you think it would be optimal to have a formal diagnosis? Yep, bc that's the only way of establishing (or approximating if preferred) what the recovery interval would be absent the use of TB-500.

Grade 2 tear. This was 2 years or so ago. I was told to ice and compression at the time and it would get better.
6 month later it wasnt better and was limping. Told to keep doing R.I.S.E and slight stretching. Didnt do shit

next doc said I have chronic exertional compartment syndrome. I might have to go the surgery route but going to give tb500 and the anti-inflammatory properties a try

 

[Dr JIM]

A grade II tear of either the Soleus or CGN shouldn't take anywhere close to six months to heal. If the diagnosis was correct the injury was recurring which hampered and significantly delayed the recovery.

Consequently I don't believe there is a baseline to compare the efficacy of TB-500 to, except healing which should have already occurred. That's to say if it "heals" one could LEGITIMATELY argue well it's about time and TB500 did not expedite that process.

 

[Dr JIM]

Incidentally how wasthe original diagnosis made? I ask bc GCN tears are MUCH more common that Soleus tears especially as isolated injuries.

 

[Joeblack]

Incidentally how wasthe original diagnosis made? I ask bc GCN tears are MUCH more common that Soleus tears especially as isolated injuries.

MRI

 

[mands]

I have used TB500 with great success and so has many others, but all anecdotal at this point. No human studies that I know have been done.

A little info on it.

• Abstract

Send to:



J Chromatogr A. 2012 Nov 23;1265:57-69. doi: 10.1016/j.chroma.2012.09.043. Epub 2012 Sep 23.
Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry.
Ho EN1, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD.
Author information

Abstract
A veterinary preparation known as TB-500 and containing a synthetic version of the naturally occurring peptide LKKTETQ has emerged. The peptide segment (17)LKKTETQ(23) is the active site within the protein thymosin β(4) responsible for actin binding, cell migration and wound healing. The key ingredient of TB-500 is the peptide LKKTETQ with artificial acetylation of the N-terminus. TB-500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation. In order to control the misuse of TB-500 in equine sports, a method to definitely identify its prior use in horses is required. This study describes a method for the simultaneous detection of N-acetylated LKKTETQ and its metabolites in equine urine and plasma samples. The possible metabolites of N-acetylated LKKTETQ were first identified from in vitro studies. The parent peptide and its metabolites were isolated from equine urine or plasma by solid-phase extraction using ion-exchange cartridges, and analysed by liquid chromatography-mass spectrometry (LC/MS). These analytes were identified according to their LC retention times and relative abundances of the major product ions. The peptide N-acetylated LKKTETQ could be detected and confirmed at 0.02 ng/mL in equine plasma and 0.01 ng/mL in equine urine. This method was successful in confirming the presence of N-acetylated LKKTETQ and its metabolites in equine urine and plasma collected from horses administered with a single dose of TB-500 (containing 10mg of N-acetylated LKKTETQ). To our knowledge, this is the first identification of TB-500 and its metabolites in post-administration samples from horses.

Copyright © 2012 Elsevier B.V. All rights reserved.

mands

 

[Joeblack]

2mg more today

 

[Joeblack]

2mg more today

 

[ebkallday]

2mg more today

How mg are you doing per week? 4?

 

[Jimmyinkedup]

Yes any update?
Ill tell you how this stuff worked with me. The anti inflammatory properties kicked in quick. This allowed me to push harder in my Physical Therapy. Subsequently I made better progress in my PT than I had prior to tb500. Also my healing prgression was significantly hastened. I knew this as the Phys Therapist's timelines were getting blown away.
So here is my theory on how this stuff works (and to my surprise it really does work IMO). The anti-inflammatory properties give you some fairly quick relief. If PT is involved you doubly benefit from this relief as you can push harder and do things you previously could not. This is good as it hastened healing. In addition to that however, there is something else at work here. The rate of healing is accelerated as well and this is not just due to increased capacity for PT intensity and volume. It is, in fact, an effect of TB500 itself.
So for me I think there is a 2 pronged effect of TB500 as far as how it works/what it actually does. TB500 has been my biggest surprise as far as peptides or any compound of the likes. I was so skeptical when I started taking it you would not believe it but it made me a believer.

 

[ebkallday]

Yes any update?
Ill tell you how this stuff worked with me. The anti inflammatory properties kicked in quick. This allowed me to push harder in my Physical Therapy. Subsequently I made better progress in my PT than I had prior to tb500. Also my healing prgression was significantly hastened. I knew this as the Phys Therapist's timelines were getting blown away.
So here is my theory on how this stuff works (and to my surprise it really does work IMO). The anti-inflammatory properties give you some fairly quick relief. If PT is involved you doubly benefit from this relief as you can push harder and do things you previously could not. This is good as it hastened healing. In addition to that however, there is something else at work here. The rate of healing is accelerated as well and this is not just due to increased capacity for PT intensity and volume. It is, in fact, an effect of TB500 itself.
So for me I think there is a 2 pronged effect of TB500 as far as how it works/what it actually does. TB500 has been my biggest surprise as far as peptides or any compound of the likes. I was so skeptical when I started taking it you would not believe it but it made me a believer.

That's awesome! I have been out of work and out of the gym with a torn quad. MRI also showed a big hematoma around the tear. This is my first week in physical therapy. My therapist measured my leg and I could only get a 60 degree bend out of it. He measured again after I warmed it up and did some stretching, I got 73 degrees. I am going through 4 rounds of streching excercises throughout each day. It hurts bad and I have some TB-500 on the way. I'm am hoping it will help get my leg healed up and bending again.

 

[Joeblack]

doing 6mg a week. I swear my calf feels better. I walked today 3.3mph on a treadmill for 45 mins. That's BIG for me

 

[Joeblack]

2mg more today

 

[Dr JIM]

Although an MRI is the most reliable means of making the diagnosis, there is only ONE reasonable explanation for your continued symptoms after SIX MONTHS RE-INJURY

Did you ever rehab the injury using a PHysical therapists guidelines and assistance?

TB5 sounds like some miracle drug since your symptoms are "improved" after just FIVE DAYS of therapy. That's called a PLACEBO effect or is on level with something that can modulate pain perception such as NSAIDS, Tylenol etc. But actual healing of your injury, not IMO.

 

[Joeblack]

Although an MRI is the most reliable means of making the diagnosis, there is only ONE reasonable explanation for your continued symptoms after SIX MONTHS RE-INJURY

Did you ever rehab the injury using a PHysical therapists guidelines and assistance?

TB5 sounds like some miracle drug since your symptoms are "improved" after just FIVE DAYS of therapy. That's called a PLACEBO effect or is on level with something that can modulate pain perception such as NSAIDS, Tylenol etc. But actual healing of your injury, not IMO.

I know its not healed. They didnt have me do any rehad then i lost my insurance and just lived with it. I know if anything its the NSAID type of effect maybe keeping the swelling down a little making me able to push a little harder. Even a placebo effect, Ill take it. Im happy to be able to walk at 3.3mph for 30 mins or more

 

[Jimmyinkedup]

Although an MRI is the most reliable means of making the diagnosis, there is only ONE reasonable explanation for your continued symptoms after SIX MONTHS RE-INJURY

Did you ever rehab the injury using a PHysical therapists guidelines and assistance?

TB5 sounds like some miracle drug since your symptoms are "improved" after just FIVE DAYS of therapy. That's called a PLACEBO effect or is on level with something that can modulate pain perception such as NSAIDS, Tylenol etc. But actual healing of your injury, not IMO.

Yes any update?
Ill tell you how this stuff worked with me. The anti inflammatory properties kicked in quick. This allowed me to push harder in my Physical Therapy. Subsequently I made better progress in my PT than I had prior to tb500. Also my healing progression was significantly hastened. I knew this as the Phys Therapist's timelines were getting blown away.
So here is my theory on how this stuff works (and to my surprise it really does work IMO). The anti-inflammatory properties give you some fairly quick relief. If PT is involved you doubly benefit from this relief as you can push harder and do things you previously could not. This is good as it hastened healing. In addition to that however, there is something else at work here. The rate of healing is accelerated as well and this is not just due to increased capacity for PT intensity and volume. It is, in fact, an effect of TB500 itself.
So for me I think there is a 2 pronged effect of TB500 as far as how it works/what it actually does. TB500 has been my biggest surprise as far as peptides or any compound of the likes. I was so skeptical when I started taking it you would not believe it but it made me a believer.

Hey Dr Jim - See the bold in my previous post. I believe you have nailed exactly what this early onset of perceived "healing" may be. It is the anti-inflammatory effects of the TB500 kicking in. You likened it to a pain modulator like an nsaid or tylenol. i think your are right on the money with your nsaid analogy. I feel like TB500 has pretty potent anti-inflammatory effects that allow you to experience the onset of relief very early on post its administration. This effect is (was for me) undoubtedly more potent than ibuprofen or naproxen as I has tried those things pre physical therapy before using the TB500 and the effects of the meds was not as pronounced as the effects of the TB500.
Like I said in my post for me this early onset of its anti-inflammatory properties was a blessing as it allowed me to more effectively perform my PT. Unlike a narcotic pain reliever however the pain relief isnt to the point of being so significant than I could actually harm myself by going overboard with my PT. It was to a level whereby I could perform the PT properly and effectively. It wasnt until later on the actual healing effects of the peptide were experienced.
As far as your placebo contention I am not dismissing that by any means but I know for me that wasnt the case because I honestly felt that TB500 was going to be a waste of money and like all the other equine cross over miracle substances end up being nothing but over hyped garbage. Also I didnt become aware of these anti-inflammatory effects until AFTER I had been using the TB500 and too my surprise it was working and working well so i delved into is MOA more thoroughly only to then learn about its AI properties. Going into this I honestly thought the stuff was gonna be useless but I had little to lose. I was, however, pleasantly surprised at its effectiveness..

 

[Joeblack]

been walking at 3.3mph for 50 mins, yesterday i ran for a total of 3 mins at 3.8mph. That is the first time running in 3 years ( come oct ) today my calf doesnt hurt at all

still doing 2mg EOD about

 

[Jimmyinkedup]

been walking at 3.3mph for 50 mins, yesterday i ran for a total of 3 mins at 3.8mph. That is the first time running in 3 years ( come oct ) today my calf doesnt hurt at all

still doing 2mg EOD about

Man thats a healthy dose. Really glad to hear it is working for you. In the realm of over hyped garbage I really feel like tb is the real deal. I am admittedly biased due to my personal experience with the compound but it if saved anyone from surgery and they achieved a full recovery I would suspect they would be as well.
Good stuff - thanks for the update!

 

[Joeblack]

Man thats a healthy dose. Really glad to hear it is working for you. In the realm of over hyped garbage I really feel like tb is the real deal. I am admittedly biased due to my personal experience with the compound but it if saved anyone from surgery and they achieved a full recovery I would suspect they would be as well.
Good stuff - thanks for the update!

thanks. This was the last resort before surgery. Im going to keep pushing it E3D, did 3 mins of running. friday i will try for 4 to 5 mins. Really i happy to be able to walk fast again. I miss doing cardio. For the last 3 years ive had the most body fat ive ever had cuz i couldnt do cardio.