Steps I am taking to raise my SHBG.

[Dr JIM]

Oh and “to support my comments”
others are well advised to take note, the FULL title of James
article is: THBG modifies Tt action and metabolism in Prostate CA cells! (How convenient CANCER was omitted James, lol)

Is SHBG involved in a number of
sex hormone mediated physiologic processes,, of course it is, but it’s NOT the holy grail James proclaims it to be by any means.

 

[James23]

Lol I love omit when ignorant fools attempt to interpret physiologic processes.

Have you ANY idea where glucoronidatiion occurs, hint a lot of drugs “bang around there”.

You like many others on PED forums see what they want to
and remove “excerpts” from the literature to support bro bullshit.


LMAO.

Jim, you're an outright quack.

"We identified a man with an undetectable SHBG concentration in combination with low total T. He presented with a 7-year history of muscle weakness, fatigue, and a low libido."

"However, passive diffusion of T alone may be insufficient for target tissues requiring large amounts of sex steroids (17, 18). This might explain some of the proband's symptoms. "

"Dialyzable free T level was normal (174 pmol/L [120–750 pmol/L]),but plasma SHBG was repeatedly undetectable using two different assays (detection limit, 0.35 nmol/L). Despite normal free T levels, the patient had multiple signs that could be related to a decreased T availability: low libido, decreased spontaneous morning erections, fatigue, muscular weakness, decreased shaving frequency (once per 4 d), inability to concentrate, sleep disturbance, and depressed mood."

 

[James23]

"Thus, low levels of SHBG have consistently been associated with a wide array of cardiovascular risk factors including visceral and subcutaneous adiposity, hypertension, dyslipidemia, and insulin resistance (4,5). Consequently, SHBG levels are low in overt type 2 diabetes and have more recently been associated with the metabolic syndrome (6–8). In addition, SHBG levels have been found to be a determinant of cardiovascular risk independently of obesity and insulin resistance (9) and can be used to predict future type 2 diabetes and metabolic syndrome in adults (7,10)"
Sex Hormone–Binding Globulin Levels Predict Insulin Sensitivity, Disposition Index, and Cardiovascular Risk During Puberty

"However, our results complement findings that expand SHBG’s role as a mediator of multiple signaling pathways in sex hormone-responsive cells (19,20,30,31). Sex hormone-bound SHBG may bind its own cell membrane receptor (19,32) and steroid-free SHBG to an endocytic receptor (20) to mediate intracellular sex hormone signaling and cell function. "

"... although the function of SHBG has classically been ascribed to the binding of steroid hormones in circulation to regulate their bioavailability, SHBG has been demonstrated to affect glycemic control [8,9] and to predict both T2D [10–12] and metabolic syndrome [13]."
Resistance training increases SHBG in overweight/obese, young men

 

[Dr JIM]

Yea so what, lol!

And how are PATHOLOGICAL STATES and SHBG derangements
to be used in otherwise NORMAL FOLK!

I know, let’s begin the APPLES to ALLIGATORS EXPERIMENT
with a little of this, some of that, a touch of whatever you want.

Post an evidence based HUMAN study in which SHBG
is/was the independent variable (rather than a marker) with clearly define outcome measures, bc in spite of your broisms praising SHBG modification as a holy grail, ignored by contemporary medicine NOT, such verbiage amounts to little more than concocted drivel.

Finally rather than formulating a cause and effect relationship based on a authors/abstracts conclusion, I suggest you try to support dogma using an articles contents, as in data.

 

[James23]

Yea so what, lol!

And how are PATHOLOGICAL STATES and SHBG derangements
to be used in otherwise NORMAL FOLK!

I know, let’s begin the APPLES to ALLIGATORS EXPERIMENT
with a little of this, some of that, a touch of whatever you want.

Post an evidence based HUMAN study in which SHBG
is/was the independent variable (rather than a marker) with clearly define outcome measures, bc in spite of your broisms praising SHBG modification as a holy grail, ignored by contemporary medicine NOT, such verbiage amounts to little more than concocted drivel.

Finally rather than formulating a cause and effect relationship based on a authors/abstracts conclusion, I suggest you try to support dogma using an articles contents, as in data.

Again, you don't understand. This is not about SHBG modification. This is not about SHBG modification. This is not about SHBG modification. Also, this is not about SHBG modification. Is it about SHBG modification? No.

This is about low SHBG being a result of a disease state and/or causing a disease state that complicates TRT to the point of reducing or preventing subjective improvement.

The study provided shows that SHBG is required for the full effect of T in a tissue specific manner. Futher provided studies show the additional roles of SHBG in intracellular and extracellular androgenic signalling beyond that of altering the rate of free diffusion.

If SHBG is low, it should be normalized. If it is not low, it should be left alone.

SHBG is the centerpiece of TRT, and that's the mainstream belief in 2018. The value changes the patient's ideal approach to TRT and expected outcome.

 

[Dr JIM]

If SHBG is low, it should be normalized. If it is not low, it should be left alone.

SHBG is the centerpiece of TRT, and that's the mainstream belief in 2018
.

What a myopic one size fits all
viewpoint, BOTH of which are BALONEY.

Why stop there and apply theorem to an endless list of LAORATORY values many of which are markers of disease as , WBC, CRP, Sed Rate etc.

Try developing a hypothesis based upon cause and effect relationships, bc you continue to see only the EGG, and ignore the CHOCKEN

 

[James23]

Because SHBG is the primary transport protien for testosterone and directly (solely) controls the free to bound ratio, and has its own effects via it's own receptor (SHBG-R) on modulating the response of androgen sensitive tissues.

Lower values (< 15 nmol/L) greatly complicate TRT and often necessitate aromatase inhibition where otherwise unnecessary. SHBG protects androgens from hepatic disposal, and lower levels of SHBG exponentially increase the metabolic clearance rate of testosterone, yet leaves the MCR of estrogen unaltered.

Free DHT, T and E2 will all be elevated to supraphysiological levels where TT is normalized (> 650 ng/dL) and SHBG is subnormal (< 15 nmol/L).

For these reasons, it is necessary to maintain SHBG within the range of 20-40 nmol/L for most men, for optimal function.

It is a trivial task to lower SHBG via danazol, and if it were truly beneficial to maintain subnormal of SHBG to increase FT in TRT patients, we would all do so, wouldn't we? However, as it turns out, there is no benefit to subnormal values of SHBG, and many patients complain of decreased response to TRT as they become too low, as the negative effects of subnormal SHBG outweigh the positive effects of free testosterone percentage.

 

[sasori540]

Hey James, finally got access to this forum.
This is sasori.
I am also a low SHBG guy.
Agree with most of your idea.
Tons of information to share but no idea where to start.
I saw your earlier post about”injectable SHBG”, have you tried that over these years?
I am asking because your calculations are wrong.
English is my tertiary language so I hope that won’t bother you.

Thank you.

 

[Misterboots]

I've been on trt for 16 years, just switched from fortesta to cypionate sub q 10 mg daily and take aromasin. 50 msg daily. Switched cause gel stopped working and total t dropped to under 150 (somewhere around this, I'll post labs). That's where I was at 16 years back when found to have microadenoma. Always had low shbg, latest labs it was at 7. I started berberine today and will do bloods in few weeks n report and then also share next round of labs too if anyone is interested. I train at least three times a week. Sugar levels on last labs were slightly high. Here are last labs.

 

[Misterboots]

Labs

 

[InfoFront]

I'm a low SHBG guy too. After seeing a few doctors, Crisler is the only one who helped me feel better at all. He put me on SubQ test EOD, daily HCG, arimidex EOD. Since me testosterone levels crashed, for unexplained reasons, I've never felt great, or even normal. We tried increasing my test dosage, but that resulted in absolutely no increase in free or total T in blood levels. 24 hour urine analysis indicated it was all being excreted.

I've been taking berberine for a couple years, but only with high-ish carb meals. I may consider taking it more regularly at 1.5g/day to see if there's any effect. I guess I should get bloodwork though.

 

[Old]

I'm a low SHBG guy too. After seeing a few doctors, Crisler is the only one who helped me feel better at all. He put me on SubQ test EOD, daily HCG, arimidex EOD. Since me testosterone levels crashed, for unexplained reasons, I've never felt great, or even normal. We tried increasing my test dosage, but that resulted in absolutely no increase in free or total T in blood levels. 24 hour urine analysis indicated it was all being excreted.

I've been taking berberine for a couple years, but only with high-ish carb meals. I may consider taking it more regularly at 1.5g/day to see if there's any effect. I guess I should get bloodwork though.

Glad you are getting some help. A few questions:

1. When your T crashed for unexplained reasons, had you ever had T and other hormones drawn beforehand to compare?
2. When you say T was all being excreted, did they also test if you were excreting all your estradiol?
3. Have you ever had any bile or bilirubin abnormalities show?
4. Now that you feel better, what are your numbers (T, FT, E2, SHBG) compared to before your current protocol?

 

[Kwirion]

Just try a gluten free diet: Cornell-China study suggests rice-based diet | Cornell Chronicle

"Though other foods such as fish and green vegetables were associated with changes in blood parameters studied, the strong effects of rice and wheat on SHBG were remarkable and unexpected," Gates said. "Women in the northern, wheat- eating counties consistently had low HDL levels, high triglycerides, and low SHBG, all suggestive of insulin resistance. Evidently, rice and wheat can have significantly different effects on the important biochemical parameters we measured."

 

[Kwirion]

You can also try other dietary tricks as well: SHBG Symptoms, Blood Test, & How to Lower/Raise Levels - Selfhacked

 

[Misterboots]

Lab f/u as promised, shbg Def increased if u look at last labs. Next change, cut low carb/no sugar n processed food diet....tried keto to start but not eating enough fat. Lost twenty pounds in past month

 

[James23]

What was your starting SHBG? I can only see the 13 nmol/L value in these photos.

I’ve been able to get mine as high as 19 with diet. I’ve seen other people go from 14 to 28 and even as high as 30 with a vigorous diet and workout routine.

 

[Misterboots]

What was your starting SHBG? I can only see the 13 nmol/L value in these photos.

I’ve been able to get mine as high as 19 with diet. I’ve seen other people go from 14 to 28 and even as high as 30 with a vigorous diet and workout routine.

 

[Misterboots]

Was at 7 back in September, bloods are in my September 12 post in ur thread. I'll get next bloods December n now on low carb no sugar diet (modified keto). Berberine continued too

 

[clear0cn]

Good article I just found about SHBG SHBG – A Modulator to be Modulated - The ZRT Laboratory Blog

 

[clear0cn]

"Pinpoint the cause of the imbalance whenever possible and instead of trying to lower a high SHBG and raise a low SHBG, zoom out to support balance in the system. If SHBG is high or low, look deeper. Always consider the main endocrine inputs: INSULIN, ESTRADIOL, THYROID."

I had issues with SHBG being to low trying to dial in trt. What worked for me was going Paleo, berberine and most importantly a steady protocol. Unfortunately after a blast this summer, I'm back where I was, on a e2 roller coaster, constantly changing T and AI dosage. I guess I was too inpatient to fsee what was really working for me back then.

This article point out that estrogen activates production of SHBG. I'm not diabetic and my T3 is fine. If you, like me been constantly crashing your e2 with Adex trying to find the sweet spot, might be worth trying to taper off your AI for a while and let your shbg stabilize. Just a thought