Do steroids damage mental health?

[Gaia262]

I have seen a marked deterioration in mental health in alcoholics and other type of drug users.

So how about anabolic steroids?

Do you feel any deterioration in your mental health using steroids?

 

[Monkipalo]

Estrogen is neuroprotective, if you crash your E2 you might have problems long term.

 

[MFAAS]

There was a recent study (last fall, I believe)) that showed changes in brain structure and the brain's reward system due to testosterone and steroid use. Also, some steroids are neurotoxic, like trenbolone and nandrolone. I use taurine, 5g per day split AM/PM, to provide some neuroprotection while on those substances.

 

[MFAAS]

Here it is: https://scihubtw.tw/10.1126/scisignal.aba1169

Was a very interesting read. I am a past drug abuser (opioids) so seeing the opioid system involved with steroids, which I now use (but no longer use opioids) was fascinating, albeit a tad concerning...

There's been quite a few studies showing changes to brain structure. Here is one: Structural Brain Imaging of Long-Term Anabolic-Androgenic Steroid Users and Nonusing Weightlifters

Here is a really good one too, at least read the abstract: Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures



Everything below this is From this reddit post:

This was specific to 19-nors, but other steroids have differing effects on the brain. I believe trenbolone is the most neurotoxic. It sucks the original post was taken down, it was really good...anyway, the whole thing isn't about neurotoxicity, but I'll just copy the whole post anyway:

Long-Term Suppression:

• 19-nors such as Trenbolone and Nandrolone—excluding Trestolone (MENT), which is twice as fast to recover from as Testosterone—are highly suppressive for up to six months or more. No one should take nandrolone or other 19-nor compounds unless they're on blast and cruise (BnC), because full recovery from PCT will be rendered largely ineffective for six months to a year—so long as to be impractical.
  Long term perturbation of endocrine parameters and cholesterol metabolism after discontinued abuse of anabolic androgenic steroids

“Even after six months LH and FSH were both still suppressed. LH and FSH recovery was correlated to the urinary level of the nandrolone metabolite 19-norandrosterone (19-NA). 19-NA was detectable for several months after the last nandrolone administration, and there was a large inter-individual variation in the excretion rate. Some individuals still tested positive even one year after their last nandrolone dose and still sustained suppression of LH and FSH during that time.”

• Trenbolone metabolites 17α-trenbolone, 17β-trenbolone and trendione are all able to convert into one another, which substantially prolongs the elimination time.

Additional Risk Factors

• Nandrolone is 11 times more damaging to blood vessels than testosterone, causes longstanding changes in the brain reward system, adversely impacts learning and memory, and induces genetic damage across multiple organ systems.
• Chronic nandrolone administration induces dysfunction of the reward pathway in rats
• Brain Imaging Study Suggests Long-Term Steroid Use Can Lead to Significant Brain Structural and Functional Abnormalities
• Gym steroid use has impact on memory
• Effects of anabolic-androgens on brain reward function
• Cognitive Deficits in Long-Term Anabolic-Androgenic Steroid Users
• Brain and Cognition Abnormalities in Long-Term Anabolic-Androgenic Steroid Users
• The Impact of Nandrolone Decanoate on the Central Nervous System
• Effects of anabolic-androgens on brain reward function
• Anabolic steroids cause longstanding changes in the brain
• Nandrolone eleven times more damaging to blood vessels than testosterone
• Nandrolone Decanoate Induces Genetic Damage in Multiple Organs of Rats
• Anxiogenic effects of chronic exposure to nandrolone decanoate (ND) at supraphysiological dose in rats: a brief report
• Voluntary exercise does not ameliorate spatial learning and memory deficits induced by chronic administration of nandrolone decanoate in rats

“Chronic exposure to the anabolic androgenic steroid (AAS) nandrolone decanoate (ND) in supraphysiological doses is associated with learning and memory impairments. Nandrolone impaired spatial learning and memory, and this effect was not rescued by exercise. The harmful effects of ND and other AAS on learning and memory should be taken into account when athletes decide to use AAS for performance or body image improvement.”

Taurine, a Neuroprotective Antioxidant
If you're going to take Nandrolone, pair it with Taurine for its antioxidant protective effects on the Leydig cells and other metabolic systems. The stuff is pretty much magic.

• Effects and Mechanisms of Taurine as a Therapeutic Agent
• Taurine Increases Testicular Function in Aged Rats by Inhibiting Oxidative Stress and Apoptosis
• The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis

Taurine helps prevent some of the damage caused by a nandrolone cycle:

• Amelioration of nandrolone decanoate-induced testicular and sperm toxicity in rats by taurine: effects on steroidogenesis, redox and inflammatory cascades, and apoptotic pathway

“Results of the present study showed that taurine reversed nandrolone decanoate-induced perturbations in sperm characteristics, normalized serum testosterone level, and restored the activities of the key steroidogenic enzymes; 3β-HSD, and 17β-HSD. Moreover, taurine prevented nandrolone decanoate-induced testicular toxicity and DNA damage by virtue of its antioxidant, anti-inflammatory, and anti-apoptotic effects.”

 

[Gaia262]

Here it is: Sci-Hub | µ-Opioid receptorâinduced synaptic plasticity in dopamine neurons mediates the rewarding properties of anabolic androgenic steroids | 10.1126/scisignal.aba1169

Was a very interesting read. I am a past drug abuser (opioids) so seeing the opioid system involved with steroids, which I now use (but no longer use opioids) was fascinating, albeit a tad concerning...

There's been quite a few studies showing changes to brain structure. Here is one: Structural Brain Imaging of Long-Term Anabolic-Androgenic Steroid Users and Nonusing Weightlifters

Here is a really good one too, at least read the abstract: Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures



Everything below this is From this reddit post:

This was specific to 19-nors, but other steroids have differing effects on the brain. I believe trenbolone is the most neurotoxic. It sucks the original post was taken down, it was really good...anyway, the whole thing isn't about neurotoxicity, but I'll just copy the whole post anyway:

Long-Term Suppression:

• 19-nors such as Trenbolone and Nandrolone—excluding Trestolone (MENT), which is twice as fast to recover from as Testosterone—are highly suppressive for up to six months or more. No one should take nandrolone or other 19-nor compounds unless they're on blast and cruise (BnC), because full recovery from PCT will be rendered largely ineffective for six months to a year—so long as to be impractical.
  Long term perturbation of endocrine parameters and cholesterol metabolism after discontinued abuse of anabolic androgenic steroids

• Trenbolone metabolites 17α-trenbolone, 17β-trenbolone and trendione are all able to convert into one another, which substantially prolongs the elimination time.

Additional Risk Factors

• Nandrolone is 11 times more damaging to blood vessels than testosterone, causes longstanding changes in the brain reward system, adversely impacts learning and memory, and induces genetic damage across multiple organ systems.
• Chronic nandrolone administration induces dysfunction of the reward pathway in rats
• Brain Imaging Study Suggests Long-Term Steroid Use Can Lead to Significant Brain Structural and Functional Abnormalities
• Gym steroid use has impact on memory
• Effects of anabolic-androgens on brain reward function
• Cognitive Deficits in Long-Term Anabolic-Androgenic Steroid Users
• Brain and Cognition Abnormalities in Long-Term Anabolic-Androgenic Steroid Users
• The Impact of Nandrolone Decanoate on the Central Nervous System
• Effects of anabolic-androgens on brain reward function
• Anabolic steroids cause longstanding changes in the brain
• Nandrolone eleven times more damaging to blood vessels than testosterone
• Nandrolone Decanoate Induces Genetic Damage in Multiple Organs of Rats
• Anxiogenic effects of chronic exposure to nandrolone decanoate (ND) at supraphysiological dose in rats: a brief report
• Voluntary exercise does not ameliorate spatial learning and memory deficits induced by chronic administration of nandrolone decanoate in rats

Taurine, a Neuroprotective Antioxidant
If you're going to take Nandrolone, pair it with Taurine for its antioxidant protective effects on the Leydig cells and other metabolic systems. The stuff is pretty much magic.

• Effects and Mechanisms of Taurine as a Therapeutic Agent
• Taurine Increases Testicular Function in Aged Rats by Inhibiting Oxidative Stress and Apoptosis
• The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis

Taurine helps prevent some of the damage caused by a nandrolone cycle:

• Amelioration of nandrolone decanoate-induced testicular and sperm toxicity in rats by taurine: effects on steroidogenesis, redox and inflammatory cascades, and apoptotic pathway

From reading this trenbolone and nandrolone should be vilified on this forum.

I plan only running micro doses of test + anavar and primo on an annual basis or on a run up to a special occasion.

Come to realise steroids are not gummy bears and can seriously mess you up.

There is no safe way of doing this, its just risk mitigation.

 

[Ferenor]

Can't you see how retarded is the average roid guy? Can't you feel my heart beating so fast?


can't you hear me knocking ?

 

[AlwaysHungry]

Trestolone you recover twice as fast as testosterone ?? Weird

 

[MFAAS]

Trestolone you recover twice as fast as testosterone ?? Weird

Studies so far show this to be true. Trest is one of the most promising anabolics out there!!! Looking forward to seeing more research come forth

 

[MFAAS]

From reading this trenbolone and nandrolone should be vilified on this forum.

I plan only running micro doses of test + anavar and primo on an annual basis or on a run up to a special occasion.

Come to realise steroids are not gummy bears and can seriously mess you up.

There is no safe way of doing this, its just risk mitigation

Unfortunately they are 2 of the most anabolic substances out there. And the damage accumulates slowly, so it is easily ignored (maybe not with tren, obviously there are some immediate negative impacts to tren).

Personally, NPP is my favorite anabolic I have ever run. I was very disappointed to learn of the deleterious effects to it. I don't know if I will run it again or not. I just get such incredible results and feel amazing the whole time. But it isn't worth the downsides.

Some of the effects may be able to protect ourselves against, like with taurine, perhapd peptides like BPC-157 or TB-500 or Epitalon. Taking adequate time off between cycles is critical. Doing your cardio, eating clean, getting enough sleep, avoiding chemical exposure such as pesticides, plastics, and other bad things (working on a post about this that I should have up in the next few days) all make a difference in preventing and healing damage induced by deleterious lifestyle choices. Not drinking, smoking, or doing drugs.

In general, if not competing, nobody should take nandrolone or tren.

That said, I just started my first tren cycle on Monday. Low dose, only 175 mg per week, just gonna see what's up with it. Then going forward I will likely stick to trestolone, testosterone, and anavar (and maybe proviron, never tried it before).

Edit: I am of the opinion that the foundational lifestyle choices I make which are far healthier than most (avoiding chemicals, eating clean and organic, having lots of air filters, having a high quality under sink water filter) mitigate or at least offset the damage from a once per year NPP cycle, or my upcoming tren experiment. That is just my opinion, and maybe I'm simply justifying it in my head, idk. Regardless, I figured I'd add that lttle tid bit.

 

[Ridethelightningbarefoot]

Well anechdotally, ive experienced increase in mental acuity. My depression is largely gone. So idk if this from lifting the depression or the aas but I dont smoke anymore or feel the need to. Drinking is less important to me where before it felt like a beed at times. A significant increase in lebido. I will probably BnC my whole life until my health goes to shit

 

[Cashton]

I have seen a marked deterioration in mental health in alcoholics and other type of drug users.

So how about anabolic steroids?

Do you feel any deterioration in your mental health using steroids?

My mental health has greatly improved since starting gear.

 

[MindlessWork]

So then according to these articles referenced if you ever had any mental issues that weren't dealt with then gear isn't really for you, especially tren!

 

[jJjburton]

I have seen a marked deterioration in mental health in alcoholics and other type of drug users.

So how about anabolic steroids?

Do you feel any deterioration in your mental health using steroids?

Clearly, have you heard yourself?

edit- or maybe that was before any aas too. Lol

edit 2- this was a joke

 

[Gaia262]

Clearly, have you heard yourself?

edit- or maybe that was before any aas too. Lol

edit 2- this was a joke

View: https://youtu.be/-7ADNCMwLDc

 

[RoidRage420]

You forgot the hardest way hormones hit you. Body dysmorphia lol

 

[Pineapples4Puss]

From reading this trenbolone and nandrolone should be vilified on this forum.

I plan only running micro doses of test + anavar and primo on an annual basis or on a run up to a special occasion.

Come to realise steroids are not gummy bears and can seriously mess you up.

There is no safe way of doing this, its just risk mitigation.

I’m glad you realized messing with your hormone system, brain, and organs is not comparable to eating gummy bears.

that is a step in the right direction.

 

[Millard]

• Nandrolone is 11 times more damaging to blood vessels than testosterone, causes longstanding changes in the brain reward system, adversely impacts learning and memory, and induces genetic damage across multiple organ systems.
• Chronic nandrolone administration induces dysfunction of the reward pathway in rats
• Brain Imaging Study Suggests Long-Term Steroid Use Can Lead to Significant Brain Structural and Functional Abnormalities
• Gym steroid use has impact on memory
• Effects of anabolic-androgens on brain reward function
• Cognitive Deficits in Long-Term Anabolic-Androgenic Steroid Users
• Brain and Cognition Abnormalities in Long-Term Anabolic-Androgenic Steroid Users
• The Impact of Nandrolone Decanoate on the Central Nervous System
• Effects of anabolic-androgens on brain reward function
• Anabolic steroids cause longstanding changes in the brain
• Nandrolone eleven times more damaging to blood vessels than testosterone
• Nandrolone Decanoate Induces Genetic Damage in Multiple Organs of Rats
• Anxiogenic effects of chronic exposure to nandrolone decanoate (ND) at supraphysiological dose in rats: a brief report
• Voluntary exercise does not ameliorate spatial learning and memory deficits induced by chronic administration of nandrolone decanoate in rats

You can't make such conclusive statements with in vitro and rat studies, and correlational studies.

Even the researchers don't go so far:

For example, correlation does not equal causation in brain changes studies. It's just speculation:

And the nandrolone is 11x worse than testosterone... it's a big leap to go from in vitro to human conclusions. Notice the qualifiers from researchers:



The conclusions are overstated, often mere speculation, and have not been proven in humans for most of these studies. We need to be careful speaking beyond what the evidence actually says.

Source:

Bjørnebekk, A., Walhovd, K. B., Jørstad, M. L., Due-Tønnessen, P., Hullstein, I. R., & Fjell, A. M. (2017). Structural Brain Imaging of Long-Term Anabolic-Androgenic Steroid Users and Nonusing Weightlifters. Biological Psychiatry, 82(4), 294–302. Redirecting

D’Ascenzo, S., Millimaggi, D., Di Massimo, C., Saccani-Jotti, G., Botrè, F., Carta, G., Tozzi-Ciancarelli, M. G., Pavan, A., & Dolo, V. (2007). Detrimental effects of anabolic steroids on human endothelial cells. Toxicology Letters, 169(2), 129–136. Redirecting

 

[Gaia262]

You can't make such conclusive statements with in vitro and rat studies, and correlational studies.

Even the researchers don't go so far:

For example, correlation does not equal causation in brain changes studies. It's just speculation:

View attachment 144511And the nandrolone is 11x worse than testosterone... it's a big leap to go from in vitro to human conclusions. Notice the qualifiers from researchers:

View attachment 144513

The conclusions are overstated, often mere speculation, and have not been proven in humans for most of these studies. We need to be careful speaking beyond what the evidence actually says.

Source:

Bjørnebekk, A., Walhovd, K. B., Jørstad, M. L., Due-Tønnessen, P., Hullstein, I. R., & Fjell, A. M. (2017). Structural Brain Imaging of Long-Term Anabolic-Androgenic Steroid Users and Nonusing Weightlifters. Biological Psychiatry, 82(4), 294–302. Redirecting

D’Ascenzo, S., Millimaggi, D., Di Massimo, C., Saccani-Jotti, G., Botrè, F., Carta, G., Tozzi-Ciancarelli, M. G., Pavan, A., & Dolo, V. (2007). Detrimental effects of anabolic steroids on human endothelial cells. Toxicology Letters, 169(2), 129–136. Redirecting

Anecdotally , I have seen people's mental health deteriorate with steroid use.

I used to work out at the same gym as Candice Armstrong who used tren, she would talk to herself and have conversations with herself , it was sad to see.

Vitalyzd (tren user ) and Connor Murphy (type of AAS use not confirmed) are both mentally ill now and were previously hyper social before.

It really does fry your brain for this reason Im stepping away from AAS and only doing the safest possible cycle on occasions like before summer. It's a luxury tool to be deployed when needed, too many people try to lean on it and feel they can make it work.

Yes they took other things but it's clear the roids exasperated it, this looks permanent damage as well.



View: https://youtu.be/xkF8LXdzZns




View: https://youtu.be/SwJ1acWmRtI

 

[Pineapples4Puss]

Anecdotally , I have seen people's mental health deteriorate with steroid use.

I used to work out at the same gym as Candice Armstrong who used tren, she would talk to herself and have conversations with herself , it was sad to see.

Vitalyzd (tren user ) and Connor Murphy (type of AAS use not confirmed) are both mentally ill.

It really does fry your brain for this reason Im stepping away from AAS and only doing the safest possible cycle on occasions like before summer. It's a luxury tool to be deployed when needed, too many people try to lean on it and feel they can make it work.

Yes they took other things but it's clear the roids exasperated it, this looks permanent damage as well.



View: https://youtu.be/xkF8LXdzZns




View: https://youtu.be/SwJ1acWmRtI

You can also argue these individuals abused other drugs along side anabolics.

conor Murphy was publicly using psychedelics and vitaly is known for his party life i can assume involved Coke and molly among other things chronically.

 

[Gaia262]

You can also argue these individuals abused other drugs along side anabolics.

conor Murphy was publicly using psychedelics and vitaly is known for his party life i can assume involved Coke and molly among other things chronically.

No doubt the roids exasperated it.