HGH Peak - Subcutaneously/ Intramuscularly

[Exitcrafter]

I have been using HGH for several years now. I don't do any big experiments with it, I prefer to use the GH pre workout and if necessary during a diet pre cardio or generally before going to bed for a better regeneration / sleep quality - mostly between 2-4iU per dose and a maximum of 4-8iU per day.

I would be very interested to know roughly when I can expect the "peak" after an HGH administration? I myself have always administered HGH intramuscularly before training about 1 hour before I get in the car and drive to the gym.

Now I found a graph that irritates me a bit. Here the GH concentration is shown highest after IM injection after about 2h. According to this, you should take the GH about 2 hours before the gym - with subcutaneous administration possibly even 3 hours before. How do you handle the timing?

 

[Rido]

Type 2 has talked about how it peaks at 2 hours prior.

A GH and fat loss protocol (rhGH lipolysis) that is science-based

Here is a gift for the Holidays from a likely forthcoming book I am considering releasing, titled Bolus: A Science-Based Guide to recombinant human Growth Hormone (rhGH) for the Athlete, Aesthete, and Aging Gym-goer This protocol is in direct contravention of the commonly touted 3-5x daily...

thinksteroids.com

 

[Type-IIx]

I have been using HGH for several years now. I don't do any big experiments with it, I prefer to use the GH pre workout and if necessary during a diet pre cardio or generally before going to bed for a better regeneration / sleep quality - mostly between 2-4iU per dose and a maximum of 4-8iU per day.

I would be very interested to know roughly when I can expect the "peak" after an HGH administration? I myself have always administered HGH intramuscularly before training about 1 hour before I get in the car and drive to the gym.

Now I found a graph that irritates me a bit. Here the GH concentration is shown highest after IM injection after about 2h. According to this, you should take the GH about 2 hours before the gym - with subcutaneous administration possibly even 3 hours before. How do you handle the timing?

Note that we don't generally care about peak GH per se (pharmacokinetics in itself), but rather we may care about peak activity of some biological effect (pharmacodynamics).

 

[Exitcrafter]

Type 2 has talked about how it peaks at 2 hours prior.

A GH and fat loss protocol (rhGH lipolysis) that is science-based

Here is a gift for the Holidays from a likely forthcoming book I am considering releasing, titled Bolus: A Science-Based Guide to recombinant human Growth Hormone (rhGH) for the Athlete, Aesthete, and Aging Gym-goer This protocol is in direct contravention of the commonly touted 3-5x daily...

thinksteroids.com

With subcutaneous injection?

 

[Exitcrafter]

Note that we don't generally care about peak GH per se (pharmacokinetics in itself), but rather we may care about peak activity of some biological effect (pharmacodynamics).

Do I understand you correctly, it is not about the "peak" concentration HGH as a substance itself but about the time in which one of the HGH effects "peaks" - for example effects like lipolysis or IGF1.
Is there more detailed information regarding the timing? In training, for example, you want to have the maximum IGF1 peak. When does this peak occur and how does the time period change if you do an IM injection instead of SQ?

 

[Type-IIx]

Do I understand you correctly, it is not about the "peak" concentration HGH as a substance itself but about the time in which one of the HGH effects "peaks" - for example effects like lipolysis or IGF1.
Is there more detailed information regarding the timing? In training, for example, you want to have the maximum IGF1 peak. When does this peak occur and how does the time period change if you do an IM injection instead of SQ?

Correct, GH pharmacokinetics, e.g. GH's moment of peak are irrelevant if e.g., a nighttime rhGH bolus confers the same benefits for something like anaerobic capacity as a pre- training bolus.

I doubt that you'll find freely available relevant materials about this subject on the internet, but it is something that I discuss at length in Bolus.

 

[Exitcrafter]

I agree with you. I have been researching HGH for years and have never found any concrete information about this topic.
I think many AAS users claim they know exactly how hgh works. However, if such "basic information" is not freely available on the internet for most people, I don't think there are many "experts" in this topic. I have been following your posts since 2021 and am very excited about your book, will definitely buy it.

 

[Smashshit]

So what’s the best time to dose gh for improved sleep/recovery and how long after your last meal?

 

[Exitcrafter]

So what’s the best time to dose gh for improved sleep/recovery and how long after your last meal?

I would say it makes sense to inject the HGH as soon as possible before going to bed. This way you could cover most of the sleep with the effective time of HGH.

 

[HB_22]

So what’s the best time to dose gh for improved sleep/recovery and how long after your last meal?

I do it right before going to bed and I have my last meal 2 hours before that.

 

[Capodecapi]

I do it right before going to bed and I have my last meal 2 hours before that.

same. you use berberine or metformin?

 

[Smashshit]

I would say it makes sense to inject the HGH as soon as possible before going to bed. This way you could cover most of the sleep with the effective time of HGH.

I do it right before going to bed and I have my last meal 2 hours before that.

Awesome thanks

 

[HB_22]

same. you use berberine or metformin?

No metformin at the moment but I did use it for a long time. Right now all I take for insulin sensitivity is semaglutide 0.5mg/week. Works great. I woke up with a bg level of 82 this morning.

 

[freakyjacked29]

No metformin at the moment but I did use it for a long time. Right now all I take for insulin sensitivity is semaglutide 0.5mg/week. Works great. I woke up with a bg level of 82 this morning.

I’d bring that down to 70 at least
Mine even after 900 carbs next day is 62 but I’m on point with blood sugar control never eat until it’s at 4.4 or under then I will eat

 

[HB_22]

I’d bring that down to 70 at least
Mine even after 900 carbs next day is 62 but I’m on point with blood sugar control never eat until it’s at 4.4 or under then I will eat

Thanks, but im alright. 82 fasted is pretty good and im currently bulking.

 

[Rido]

I’d bring that down to 70 at least
Mine even after 900 carbs next day is 62 but I’m on point with blood sugar control never eat until it’s at 4.4 or under then I will eat

70-99 is normal. you could have a fasted GH at 105 but an a1c of sub 5%. its not a big deal

 

[freakyjacked29]

70-99 is normal. you could have a fasted GH at 105 but an a1c of sub 5%. its not a big deal

Sure it’s normal but less is best you’ll see by mirror and bodyfat responds too food etc currently on 12iu gh too and just prefer lower than normal blood sugars personally

But 80s is good

 

[Rido]

Sure it’s normal but less is best you’ll see by mirror and bodyfat responds too good etc currently on 12iu gh too.

Everyone is different. I have ran 10 with minimal increase as well.


If less was best then there would be no lower limit

 

[freakyjacked29]

Everyone is different. I have ran 10 with minimal increase as well.


If less was best then there would be no lower limit

Yeah that’s true good response

 

[Capodecapi]

Yeah that’s true good response

Whats your protocol for That BG on 12 Iu ?