Anecdotally, Indapamide nuked my BP. I was ~120/60ish on 10mg Amlodipine, 80mg Telmi, 5mg Nebivolol, and it dropped it to 90/60 within two days at just a 1.25mg dose.
MESO-Rx
Anabolic Steroids
MESO-Rx Sponsor PCT 24X7 "1 stop shop for all day healthcare"
- Thread starter PCT24X7 PHARMACY
- Start date
malfeasance
Member
I cannot tolerate hydrochlorothiazide even at 12.5 mg - I get horrible cramping when working out or on hot days. I literally see stars when doing intense leg training.
Since Google tells me "Indapamide is a thiazide-like diuretic with antihypertensive effects," can you tell me more about it? I'll keep reading, too. Thanks for sharing.
malfeasance
Member
No answer because I am overmedicated already and still have shitty blood pressure and this is why we tell young folks not to do steroids because when they are old they will be like malfeasance?
Thiazide like diuretics seem to be much better tolerated than hctz, and it also has a much better 24 hour antihypertensive effect, allowing for once daily dosing. Here's a good read that I found a while back when going down the BP rabbit hole.
Ghoul
Member
I'd add 10mg, the typical starting dose.
Combined with Telm 80/Meto 50 You can expect an additional reduction of:
• Systolic BP: ~8-12 mmHg
• Diastolic BP: ~5-7 mmHg
Which puts you near ideal without any significant risk of hypotension.
Also, Cilnipidine doesn't cause any reflex tachycardia (raised RHR as BP drops), and you may even experience a small drop, up to 3 BPM since it works synergistically with metoprolol.
IF you turn out to be a hyperresponder and you drop too much at 10mg you can always cut them in half.
Also, risk of edema is very low. Telmisartan actually lowers the already low risk of edema from Cilnipidine even lower.
malfeasance
Member
Yeah, I have amlodipine, but I got gross swelling of my ankles and feet.
Ghoul
Member
In India, Amlodipine is the cheapest CCB, and the most commonly used.
The primary reason a doctor there would switch to more expensive Cildipidine is if the patient develops edema, and in the overwhelming majority of cases, it goes away after making the switch.
So it should work very well for you.
Last edited:
malfeasance
Member
Thanks for your input, Ghoul.
malfeasance
Member
metoprolol
So I mentioned above that I have the tartrate version which is not intended for once daily. Half life = typical 3-4 hours.
I have extra.
Last night my heart was pounding, stress from work, etc., so I took an evening dose in addition to my morning dose (50 mg each). Things calmed down, heart settled down, decent night's sleep, etc.
One effect is it lowered my heart rate during cardio the next morning. I always take the morning dose after fasted cardio, not before.
Morning cardio this morning. 37 minutes on the stairs. This is two more minutes than yesterday.
My heart rate yesterday was 153 beats per minute, but this morning, after my extra one time night dose of metoprolol last night, was only 134 bpm.
No increased perception of exertion or anything like that.
This raises numerous questions for me. Here are the top two. So does metoprolol interfere with the cardiac effects of exercise? In other words, is my cardiovascular exercise as beneficial as if there was no metoprolol in my blood?
How is a slower heart beat still getting the same amount of oxygen circulated as a faster heart beat?
Things to ponder
So I mentioned above that I have the tartrate version which is not intended for once daily. Half life = typical 3-4 hours.
I have extra.
Last night my heart was pounding, stress from work, etc., so I took an evening dose in addition to my morning dose (50 mg each). Things calmed down, heart settled down, decent night's sleep, etc.
One effect is it lowered my heart rate during cardio the next morning. I always take the morning dose after fasted cardio, not before.
Morning cardio this morning. 37 minutes on the stairs. This is two more minutes than yesterday.
My heart rate yesterday was 153 beats per minute, but this morning, after my extra one time night dose of metoprolol last night, was only 134 bpm.
No increased perception of exertion or anything like that.
This raises numerous questions for me. Here are the top two. So does metoprolol interfere with the cardiac effects of exercise? In other words, is my cardiovascular exercise as beneficial as if there was no metoprolol in my blood?
How is a slower heart beat still getting the same amount of oxygen circulated as a faster heart beat?
Things to ponder
- Hypertension: The usual initial dose of metoprolol tartrate is 100 mg daily in single or divided doses. The maintenance dosage is 100 to 450 mg per day. The usual initial dosage of Metoprolol succinate is 25 to 100 mg daily. The maintenance dosage is 100 to 400 mg daily. The dosage may be increased weekly or longer until the optimum blood pressure reduction is achieved.
sinistral
Member
Here's some information from my experimentation around these questions which may or may not be useful to you.
As for exercise I found that Nebivolol didn't seem to reduce my RHR however it did impact my cardio. I was able to put out about 10 more watts on an air bike and maintain the same average heart rate (130 BPM). However my blood lactate was 4.3 mmol/l where it would normally be less than 2 mmol/l.
As for slower heart beat and circulation I think I did have reduced blood flow to my toes. I say this because the balls of my feet and middle toes hurt during a run where they normally would not. Increasing daily cialis from 5mg to 10mg eliminated this pain however it caused shin splints during the run.
I am still investigating this stuff so the above is not fully fleshed out but just some data to chew on.
malfeasance
Member
Wait - how did you measure that? And why did you think to do so?
sinistral
Member
I use Lactate Plus Meter. Same idea as a glucose meter only measuring lactate. It is a better proxy than heart rate to measuring zone cardio training. The heart rate may be up or down on any given day due to many factors but the lactate is a more direct way to measure what the mitochondria are actually doing.
malfeasance
Member
So what do I want lactate to be doing to . . . what about my mitochondria? Sorry, this is a new one for me.
Google, here I come.
Google, here I come.
Ghoul
Member
Dilated blood vessels lower blood pressure (less resistance to blood flow), allowing for greater stroke volume, so cardiac output increases delivering more oxygen, despite a slower beat.
sinistral
Member
If general health is a concern of yours then mitochondrial health is key. Definitely do some research.So what do I want lactate to be doing to . . . what about my mitochondria? Sorry, this is a new one for me.
Google, here I come.
When mitochondria are burning mostly fat for energy then blood lactate is low. The lactate rises as more and more glucose is burned. You are improving the efficiency or the number of mitochondria in the muscle if you can put out more power for the same level of lactate.
I've seen some of your posts on RHR and blood pressure. I think you will find the topic of mitochondrial health very interesting.
LawrenceofUSA
New Member
Narc lmao jk
BP_6
Member
One drug not talked about much recently is mildronate. Very similar to Trimetazidine. Both reduce fatty acid usage in the mitochondria and force more glucose usage. Reduces free radicals and oxygen requirements which is especially helpful for some heart issues. Was banned by WADA many years back when they found a buttload of athletes testing positive for it.
LawrenceofUSA
New Member
Would you recommend dosing cilnipidine twice daily due to the 7ish hour half life?
Similar threads
