Ghoul
Member
Would you recommend dosing cilnipidine twice daily due to the 7ish hour half life?
No need. It does a good job of sustained BP control over 24 hours (better than Amlodipine in fact), especially after daily use for a few weeks because it's highly lipophilic, and you become "saturated" with it which keeps levels stable throughout the entire day.
It's only rarely recommended twice daily if there's a significant surge in blood pressure in the morning, and even then, they'll try adding an ARB first.
