RedSalmon
New Member
I’m curious if microneedling actually has any positive effect?
MESO-Rx
Anabolic Steroids
Hair Loss
- Thread starter billydidit
- Start date
Ghoul
Member
As a datapoint (from someone hypersensitive Fin, 1mg induced the worst possible sides):
.25mg / day (quarter tab) Fin worked well for over a year, starting with barely perceptible sides that disappeared after the first week.
.50mg/ day Fin significantly diminished motivation and libido. Stopping for 2 weeks restored everything to normal, as expected. Urine flow slowly diminished as, I presume, prostate started to enlarge.
.125mg/ day (quarter tab) Dutasteride no sides whatsoever, despite this dose being 50% stronger for systemic DHT reduction than Fin .25mg. Perhaps it's because Dut doesn't cross the blood brain barrier very well, so it doesn't suppress the production of neurosteroids like Fin. Urine flow restored to what it had been with Fin, perhaps a bit better.
Also, despite Dut's very long half life, which theoretically allows intermittent doses to maintain stable DHT levels, there are multiple advantages to daily microdoses vs 1 or 2 larger doses a week.
1. Avoiding short lived, but much higher blood level peaks after consuming larger doses. This seems to minimize the risk of some potential side effects.
2. The most effective hair loss/regrowth target for DHT reduction is Type 1, intercellular 5-AR conversion in the scalp (only Dut inhibits Type 1), not lowering systemic DHT. Intercellular 5-AR conversion is more effectively suppressed by maintaining consistent levels of Dutasteride via daily dosing, rather than spiking it with intermittent higher doses.
.25mg / day (quarter tab) Fin worked well for over a year, starting with barely perceptible sides that disappeared after the first week.
.50mg/ day Fin significantly diminished motivation and libido. Stopping for 2 weeks restored everything to normal, as expected. Urine flow slowly diminished as, I presume, prostate started to enlarge.
.125mg/ day (quarter tab) Dutasteride no sides whatsoever, despite this dose being 50% stronger for systemic DHT reduction than Fin .25mg. Perhaps it's because Dut doesn't cross the blood brain barrier very well, so it doesn't suppress the production of neurosteroids like Fin. Urine flow restored to what it had been with Fin, perhaps a bit better.
Also, despite Dut's very long half life, which theoretically allows intermittent doses to maintain stable DHT levels, there are multiple advantages to daily microdoses vs 1 or 2 larger doses a week.
1. Avoiding short lived, but much higher blood level peaks after consuming larger doses. This seems to minimize the risk of some potential side effects.
2. The most effective hair loss/regrowth target for DHT reduction is Type 1, intercellular 5-AR conversion in the scalp (only Dut inhibits Type 1), not lowering systemic DHT. Intercellular 5-AR conversion is more effectively suppressed by maintaining consistent levels of Dutasteride via daily dosing, rather than spiking it with intermittent higher doses.
AlexDavis43
Member
no I do it for fun
haven't chimed in here in a while, seeing a fair bit of fear-mongering BS in some of these recent posts, so I will contribute my own experience. I started to notice hairless when I took primo for a while, which was stupid because I hardly noticed any effect other than it fucking up my hair. in the last year and 3 months I have tried:
- Topical min/dut/RU
- Oral min/dut/RU
- Combo of Oral and Topical min/dut and topical RU
my current protocol is 2.5 mg min and .5 mg Dut twice a day orally, and once a day topical min/dut/RU. I have been off everything except 200mg/week Test for the last year or so. I have noticed ZERO additional hairloss, and my hair is all over much healthier and thicker than it was. Hair loss at the temples is still there but there are small hairs that seem to be making a very, very slow comeback. Presumably in another year my hair and hairline will be better than it has been in the last 5. No negative side effects to speak of, at least none that I can concretely correlate to any of these compounds. Sex drive and all that are completely fine, I have always been a "once a day" kinda guy and that hasn't changed at all other than a very brief dip in libido for maybe 3-4 weeks when I went from .5mg dut to 1 mg dut per day, but it came back to normal after that.
TL
R: the drugs do work and side effects are often transient and in my opinion very exaggerated. keep your estrogen a little high, take a multivitamin, take your meds, don't take DHT derivatives, and give it time.
- Topical min/dut/RU
- Oral min/dut/RU
- Combo of Oral and Topical min/dut and topical RU
my current protocol is 2.5 mg min and .5 mg Dut twice a day orally, and once a day topical min/dut/RU. I have been off everything except 200mg/week Test for the last year or so. I have noticed ZERO additional hairloss, and my hair is all over much healthier and thicker than it was. Hair loss at the temples is still there but there are small hairs that seem to be making a very, very slow comeback. Presumably in another year my hair and hairline will be better than it has been in the last 5. No negative side effects to speak of, at least none that I can concretely correlate to any of these compounds. Sex drive and all that are completely fine, I have always been a "once a day" kinda guy and that hasn't changed at all other than a very brief dip in libido for maybe 3-4 weeks when I went from .5mg dut to 1 mg dut per day, but it came back to normal after that.
TL
R: the drugs do work and side effects are often transient and in my opinion very exaggerated. keep your estrogen a little high, take a multivitamin, take your meds, don't take DHT derivatives, and give it time.Bro why are you dermarolling your stomach,calves and legs?
AlexDavis43
Member
I don't know but if it can cause permanent hair loss I might try it. From the neck down.
@HUGE McBIGLARGE
IronMetal_2
New Member
Not sure if Im just an an outlier but dutasteride feels like a sugar pill despite my serum dht being beyond nuked lol. Taking 1mg / day dutasteride. started with 0.5 mg, took 2.5 mg for a couple weeks and now staying on 1 mg.
also on 2.5 mg minoxidil.
Zero side effects, libido great, arguably even better. Only getting some more body hair from the minox.
also on 2.5 mg minoxidil.
Zero side effects, libido great, arguably even better. Only getting some more body hair from the minox.
HUGE McBIGLARGE
Member
To apply Testogel there. I couldn’t just spam Dermaroll my arms every day.
RandallFlagg
Member
Missed this original question - Fin and Dut both just seem to make me feel some variation of either "emotionally dead" or just a mild asshole (mostly just lack empathy and don't care about being an ass...not out of control...just like "hey... you're a bitch....byeeee" and not give a fuck about the fallout...lol).
It does lower my interest in sex though don't recall it ever really giving me issues with actual erections. I just couldn't really ever stick with either med for longer than 2 weeks runs because I noticed it every..single... time.
I don't care if it's called psychosomatic or what other bullshit...but it causes issues and affects people differently. That doesn't mean no one should use it...every medication has a chance of causing issues. I think the worrisome part is always the stories that "the issue is permanent/forever/you're doomed" that obviously leads to concern.
I do worry about messing with DHT and I definitely don't think the AR inhibitors are as benign as some people want to make them out to be.... buuuut I'm also not convinced any effects are permanent for like 99.1% of the population.
As for Cialis - yes, use it daily at 5mg. Oddly, no benefit for urination. Wild how these meds effect each of us so differently.
Just inject big dawg
HUGE McBIGLARGE
Member
This was before I had injectable stuff
Orc419
Member
Anyone have knowledge of the difference between oral and topical routes for fin/dutasteride? I am currently using a fin/minox topical solution daily for hair loss since I thought I could avoid body-wide side effects, however I've had horrible sides as far as energy and libido go. Just got a script for oral dutasteride and I am hoping it won't be worse than fin.
In short, does a topical solution dissolve into the blood stream and create body-wide effects the same as an oral route?
In short, does a topical solution dissolve into the blood stream and create body-wide effects the same as an oral route?
HUGE McBIGLARGE
Member
Yes. But to a lesser severity. Anything strong enough to permeate your skin is strong enough to enter the blood.
HUGE McBIGLARGE
Member
There are three caveats I didn’t think of.
Systemic absorption of topicals can vary massively depending on a number of factors. Weather, your own bodily cleanliness, hair length, time between dosages, and probably like ten other things. This may mean on some days you’re absorbing more than you’d like.
It’s also possible that the systemic absorption could be very “front-loaded”. Meaning it’s possible that 1 hour after application your systemic levels of the drug could actually be higher than if you took an oral. This is due to orals possibly absorbing slower than topicals.
You also have no way of knowing what dose you’re actually absorbing systemically without taking several DHT tests. I know from my own experience with topical testosterone that the systemic levels of testosterone could vary massively from day to day, despite all controllable variables being the same.
Having said all that, if you take the minimum effective dose necessary to keep your hair, you should still fare better with a topical than with an oral.
Orc419
Member
I definitely agree that's there isn't a way to know what dosage you are getting, the best way to judge would be to observe hair loss and side effects over time, and adjust from there. I would rather go with topical seeing as it is more direct and possibly less systematic in It's application, however it has been extremely difficult and expensive to find a pharmacy that will fill topical scripts (at least with fin). I think I will go with underground sources. I can't be laying $100+ a month to keep my hair lol
Wait. U using topical fin? Dutasteride is harder to permeate the skin so it may stay in your scalp and not as systemic.
I hope you're not doing oral Dutasteride. It's last thing u'll want. Dick stops working even if u have libido, depression sets in, lack of motivation and drive and the worst part it lingers in your system FOR MONTHS!
Orc419
Member
I plan on using topical dutasteride once I can get it, however I needed something in the meantime so I went with the oral route for now. Switching from topical finasteride to oral dutasteride made me feel way better already, although I still have almost no libido, but it's better. I will roll with it a while and see if it is something I can go with long term. I was aware of the very long half life before I started.
Hair loss is a real bitch but I'm not ready to go bald before I'm even 30.
Ateam2023
Member
whats a good finesteride to get from pct24/7? My brother wants to stop receding hairline and im curious if anyone had a recommendation? tia
Photon
Member
Any of the "heal" stuff is pretty reliable.
Its produced by Healing Pharma.
I used to use HEALPECIA for fin before switching to Dutasteride.
Ateam2023
Member
i read that a combo of both fin/dut is a good option?
Similar threads
