Because of total cholesterol..if you drop that below 100 you can't have a high HDL it's like mathematically impossible
At least in my experience
MESO-Rx
Anabolic Steroids
Cholesterol numbers on no med, then on statin then on statin + Repatha
- Thread starter jtmarlin
- Start date
At least in my experience
BamaCrazy
Banned
That’s interesting. I’ve always struggled to get my HDL up, even before TRT and AAS use. Now that I am trying to push total cholesterol and LDL low as possible I might be lowering my HDL also.
egruberman
Member
I’ve mentioned before, but in the presence of low LDL and ApoB in particular HDL levels are less meaningful.
The “ratio” suggested isn’t particularly closely associated with risk. In the presence of elevated LDL, HDL will help clear some of it and reduce the atherogenic burden.
BamaCrazy
Banned
Then I am good to go. In January my ApoB was 49, LipoA <8.4, Total Cholesterol 84, LDL 38, but HDL was 35. That was when I also got a 0 CAC score.
Wizbang
Member
PCSK9 inhibitors changed my life. I am unfortunately one of those people who do not respond well to statins. I went from 278 cholesterol to 132 with PCSK9i and lifestyle changes. They are truly incredible.
Wizbang
Member
Posting data for folks, so 2021 I was on max dose Rosuvastatin and Ezetimibe and lifestyle/dietary changes. Cardiologist swapped me at that time to Praluent 75 EOW, and from there on it's just been Praluent, Fish oil (*EPA only* 1g) and lifestyle/dietary changes. Now whether or not the fish oil is even doing anything is unknown but the numbers are nice to watch.
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I thought I'd update this thread while running gear and eating very low fats during a contest prep. I'm taking Omega 3 and only eating 30-40g of fat per day and most are just trace fats not direct fatty foods.
I'm using 60mg of test cyp + 30mg of primo daily = 420/210 per week.
I'm using 5mg Lipitor daily (I break the 10mg in half) + Repatha every 2 weeks.
HDL 21
LDL 32
ApoB 45
Triglycerides 92
I have used this dose/combo of AAS before and my HDL has not been this low. When I was not on any cholesterol lowering medicine on 600 test + 400 primo my HDL was 29 LDL 180 ApoB 130.
I'm now 100 percent convinced that Repatha is lowering my HDL by 10-15 points. It's been across nearly all blood tests no matter with additional statin therapy or varying levels of AAS. The thing I don't know is if it matters. When I saw the cardiologist and was only on my TRT dose of testosterone, they were not concerned at all that my HDL was 40ish bc my LDL and AppB were so low. I wonder if there is a level of HDL on the lower end that matters for risk if these other numbers are so low.
Unless I'm in the genetic outlier I have no idea how these guys I watch on IG or other places take all this frigging primo/masteron etc and have "totally fine lipids" without using cholesterol medicine. Primo is EXTREMELY dangerous in terms of lipid alterations. Unless they simply don't check and are lying. I've tried playing this game of adding healthy fats to meals and it literally does nothing. A handful of cashews, 1/3 of and avocado etc are doing shit for boosting HDL IME.
I'm using 60mg of test cyp + 30mg of primo daily = 420/210 per week.
I'm using 5mg Lipitor daily (I break the 10mg in half) + Repatha every 2 weeks.
HDL 21
LDL 32
ApoB 45
Triglycerides 92
I have used this dose/combo of AAS before and my HDL has not been this low. When I was not on any cholesterol lowering medicine on 600 test + 400 primo my HDL was 29 LDL 180 ApoB 130.
I'm now 100 percent convinced that Repatha is lowering my HDL by 10-15 points. It's been across nearly all blood tests no matter with additional statin therapy or varying levels of AAS. The thing I don't know is if it matters. When I saw the cardiologist and was only on my TRT dose of testosterone, they were not concerned at all that my HDL was 40ish bc my LDL and AppB were so low. I wonder if there is a level of HDL on the lower end that matters for risk if these other numbers are so low.
Unless I'm in the genetic outlier I have no idea how these guys I watch on IG or other places take all this frigging primo/masteron etc and have "totally fine lipids" without using cholesterol medicine. Primo is EXTREMELY dangerous in terms of lipid alterations. Unless they simply don't check and are lying. I've tried playing this game of adding healthy fats to meals and it literally does nothing. A handful of cashews, 1/3 of and avocado etc are doing shit for boosting HDL IME.
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BamaCrazy
Banned
400mg Primo had my HDL around 32. 600mg has it at 19 right now. I take Rosuvastatin and Ezitimibe. My LDL is 43, total cholesterol is 78, and triglycerides 76.
When I was natty and had low T 300 and free T 7, my HDL was 80. It's amazing the degree to which androgens impair HDL. This is the single biggest risk IMO in the whole game.
Wizbang
Member
You could try Niacin to increase HDL, I am unsure of the effects given the AAS pushing them down, but might be worth a shot? I know dosing from studies shows you need 1g-1.5g of niacin daily to raise HDL up, some studies have shown upwards of 20-30% increase. If flushing is an issue take 325mg aspirin 30 mins prior to dosing. I am on a PCSKi but not on cycle and I haven't noticed a significant drop in HDL.
As a note you do not want flush free niacin, unfortunately you need the good ole fashion stuff.
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BamaCrazy
Banned
My HDL has always been around 40-44 natty so 400mg Primo really didn’t drag it down much. 600mg killed it though. My other lipids and ApoB are also low and my CAC score was zero. That’s about all I can do to mitigate risk. I’m coming off my cycle now and letting everything reset.
BP_6
Member
I sure wish a peptime manufacturer would find a way to come out with evolocumab. It obviously has some complications or they likely would have already. I have a script, it is just my insurance told me to go take a hike since my statin is working fine by their standards.
Wizbang
Member
Reach out to the manufacturer, both Repatha and Praluent have huge discount cards they offer if insurance doesn't cover it well or at all.
It's a biologic. I'm not sure a run of the mill peptide manufacturer could produce it.
Wizbang
Member
very unlikley, it is a monoclonal antibody, much more finicky.
Have you discussed this issue of driving your HDL so low with your prescriber? Have they given you an opinion on whether it matters if your ApoB is so low?
Wizbang
Member
I'd be curious what your E2 is while on cycle, since estrogen is critical for cholesterol production.
There's nobody monitoring me. I pay out of pocket for Repatha. 250$ a month here in Europe. I guess nobody really knows to answer to your question... It's not ideal but we're doing the best we can with it.
I'm not sure you are asking me specifically but those cholesterol numbers of mine are with a 34 E2 on 420 test 210 primo
