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Anabolic Steroids

PT-141 in Clinical Trials w/ Tirzepatide

docpepper

docpepper

Member
Thought some of you guys might find this interesting. The company who created PT-141 (Bremelanotide) just finished Phase 2 trials studying the combo of PT-141 + Tirz for obesity. Data expected later this quarter according to the press release. Something interesting to look out for.

Palatin Completes Phase 2 Obesity Study With MC4R Bremelanotide Plus GLP-1/GIP Tirzepatide | Palatin Technologies

Feb 06, 2025, 07:30 ET Last Patient / Last Visit Completed Topline Data Readout Expected Later This QuarterCRANBURY, N.J., Feb. 6, 2025 /PRNewswire/ -- Pala ...
palatin.com palatin.com

They're also trying to make an oral melanocortin-4 agonist (mechanism of action for MT-2 and PT-141), and a weekly injectable MC4 agonist, both for obesity. They're really pushing the obesity with this thing. If you only the FDA would be cool with MT-2 + Tirz. Overnight bestseller that would rip chicks out of high-waisted jeans and into bikinis.

I'm familar with MT2 but not PT-141. Anyone have some thoughts on this, happens to know a little about what's going on at Palatin?
 
docpepper said:
Thought some of you guys might find this interesting. The company who created PT-141 (Bremelanotide) just finished Phase 2 trials studying the combo of PT-141 + Tirz for obesity. Data expected later this quarter according to the press release. Something interesting to look out for.

Palatin Completes Phase 2 Obesity Study With MC4R Bremelanotide Plus GLP-1/GIP Tirzepatide | Palatin Technologies

Feb 06, 2025, 07:30 ET Last Patient / Last Visit Completed Topline Data Readout Expected Later This QuarterCRANBURY, N.J., Feb. 6, 2025 /PRNewswire/ -- Pala ...
palatin.com palatin.com

They're also trying to make an oral melanocortin-4 agonist (mechanism of action for MT-2 and PT-141), and a weekly injectable MC4 agonist, both for obesity. They're really pushing the obesity with this thing. If you only the FDA would be cool with MT-2 + Tirz. Overnight bestseller that would rip chicks out of high-waisted jeans and into bikinis.

I'm familar with MT2 but not PT-141. Anyone have some thoughts on this, happens to know a little about what's going on at Palatin?
Click to expand...

So PT-141 in this case just help reducing craving and the desire to binge eating or what exactly is the mechanism?
 
Ghoul said:
PT and MT-2 lower appetite (I don't know why). Not hugely, but certainly a noticeable amount. I always feel more energetic on either.
Click to expand...
I wish. I always feel a bit more lethargic on both. More so with MT-2 than PT. I also find the urge to "stretch and reach" as though I had been in car too long. The second effect is odd but definitely happens every time I use either one, but that effect is more pronounced with PT.

I'm also curious why they chose to combine PT with Tirzepatide. PT-141 is already FDA approved for low sexual arousal for women, but I have no idea if they're trying to capitalize on that aspect of the drug.
 
cmK9s33 said:
I wish. I always feel a bit more lethargic on both. More so with MT-2 than PT. I also find the urge to "stretch and reach" as though I had been in car too long. The second effect is odd but definitely happens every time I use either one, but that effect is more pronounced with PT.

I'm also curious why they chose to combine PT with Tirzepatide. PT-141 is already FDA approved for low sexual arousal for women, but I have no idea if they're trying to capitalize on that aspect of the drug.
Click to expand...


The "stretch", "self grooming behavior", "yawning" are hypothesized to be associated with the libido effect these compounds have on the brain, stimulating sex signaling behavior. It's observed in other mammals given the drugs too.
 
Ghoul said:
The "stretch", "self grooming behavior", "yawning" are hypothesized to be associated with the libido effect these compounds have on the brain, stimulating sex signaling behavior. It's observed in other mammals given the drugs too.
Click to expand...
It's definitely interesting. I figured it had to be related to something going on in my head or maybe a CNS effect at work in the background.
 
cmK9s33 said:
It's definitely interesting. I figured it had to be related to something going on in my head or maybe a CNS effect at work in the background.
Click to expand...

These unconscious behaviors diminish with age, and, especially in males, skin tone pales as melanocortin receptor agonism diminishes. This "paling out" is hypothesized to be a signal of poor mating potential.

Testosterone plays a role in this skin tone sexual signaling as well. Some new users of steroids notice this especially in darkening of the hands. It's because testosterone increases the number of melanocytes (pigmentation skin cells), enlarges and elongates them.
 
For me, PT-141 feels like the combo of a hangover and a sunburn for like 12 hours. 1.5mg subq/ED I wouldn't eat and would lose weight too.

Also my dick would probably fall off.
 
docpepper said:
Thought some of you guys might find this interesting. The company who created PT-141 (Bremelanotide) just finished Phase 2 trials studying the combo of PT-141 + Tirz for obesity. Data expected later this quarter according to the press release. Something interesting to look out for.

Palatin Completes Phase 2 Obesity Study With MC4R Bremelanotide Plus GLP-1/GIP Tirzepatide | Palatin Technologies

Feb 06, 2025, 07:30 ET Last Patient / Last Visit Completed Topline Data Readout Expected Later This QuarterCRANBURY, N.J., Feb. 6, 2025 /PRNewswire/ -- Pala ...
palatin.com palatin.com

They're also trying to make an oral melanocortin-4 agonist (mechanism of action for MT-2 and PT-141), and a weekly injectable MC4 agonist, both for obesity. They're really pushing the obesity with this thing. If you only the FDA would be cool with MT-2 + Tirz. Overnight bestseller that would rip chicks out of high-waisted jeans and into bikinis.

I'm familar with MT2 but not PT-141. Anyone have some thoughts on this, happens to know a little about what's going on at Palatin?
Click to expand...
Ha- sounds like there's gonna be a lot of horny, heavy women to be had in the future, fellas.
 
Melanotan 2 could possibly treat autism.

Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism - PMC

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impaired social interactions, difficulty with communication, and repetitive behavior patterns. In humans affected by ASD, there is a male pre-disposition ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Its also meant to be neuroprotective and anti inflammatory

pubmed.ncbi.nlm.nih.gov

The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat - PubMed

The neurotrophic and neuroprotective potential of the alpha-melanocyte-stimulating hormone (alpha-MSH) analog cyclo-[Ac-Nle(4),Asp(5),D-Phe(7),Lys(10)]alpha-MSH-(4-10) amide (melanotan-II), a potent melanocortin receptor agonist, was investigated. The sciatic nerve crush model was used as a...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
 
Ghoul said:
PT and MT-2 lower appetite (I don't know why). Not hugely, but certainly a noticeable amount. I always feel more energetic on either.
Click to expand...
If you count nausea as lowering appetite :p

There's gonna be a lot of unplanned pregnancies if they start pushing a double PT141/Tirz treatment across the country in significant numbers lol.

PT141 made me realize a two hour boner is not all I thought it would be.
 
wp_375 said:
If you count nausea as lowering appetite :p

There's gonna be a lot of unplanned pregnancies if they start pushing a double PT141/Tirz treatment across the country in significant numbers lol.

PT141 made me realize a two hour boner is not all I thought it would be.
Click to expand...

The excess food supply from fewer fatsos gobbling it up means the system can breed more workers now.
 
Volute said:
For me, PT-141 feels like the combo of a hangover and a sunburn for like 12 hours. 1.5mg subq/ED I wouldn't eat and would lose weight too.

Also my dick would probably fall off.
Click to expand...
Dude same. I’ve been sober for over 4 years now and PT fucks me up wild like that. Even the next day I’m still nauseous, exhausted, anxious and depressed and hypotensive. I love it bc I fuck like a porn star when I mix it with oxytocin but I get nauseous just thinking about heading to the fridge to take make the combo.
 
Docsunshine23 said:
Dude same. I’ve been sober for over 4 years now and PT fucks me up wild like that. Even the next day I’m still nauseous, exhausted, anxious and depressed and hypotensive. I love it bc I fuck like a porn star when I mix it with oxytocin but I get nauseous just thinking about heading to the fridge to take make the combo.
Click to expand...
lol same. With pt141 or mt2 I start feeling sick the moment I think about taking them.
 
Docsunshine23 said:
1mg a day?! I’d be absolutely useless laying in bed exhausted, miserable and nauseous. Popping IM zofran and phergan every 3 hours and chugging pepto.
Click to expand...
I took 1mg the other night. Felt fine for 2 minutes. Then very very sick for 10 minutes. Then fine again.

You build a big tolerance to it
 
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