Glp1 hgh and other peptide storage

[Diixencider]

Can I put unconstituded hgh, glp1s and other peptides in my freezer for a longer shelf life?

 

[Ghoul]

Can I put unconstituded hgh, glp1s and other peptides in my freezer for a longer shelf life?

If it's less than a year or so refrigeration is sufficient and on balance, a better bet than freezing to keep degradation to a minimum

There are a number of variables here, and unless you're looking to preserve multiyear / apocalypse stockpiles, this is the simplest rule of thumb that applies, generally, to all peptides.

 

[Diixencider]

If it's less than a year or so refrigeration is sufficient and on balance, a better bet than freezing to keep degradation to a minimum

There are a number of variables here, and unless you're looking to preserve multiyear / apocalypse stockpiles, this is the simplest rule of thumb that applies, generally, to all peptides.

I'm just reselling and currently just use my fridge. I didn't know if the freezer was better but as you pointed out the freeze could degrade the quality and I def don't want that lol

 

[Ghoul]

I'm just reselling and currently just use my fridge. I didn't know if the freezer was better but as you pointed out the freeze could degrade the quality and I def don't want that lol

The colder the temp, the slower chemical degradation happens. The colder, the better.

But the problem with freezing is physical degradation. All peptides have a residual moisture content. This moisture is bound up with the protein, and when ice crystals expand, they can physically break some peptide molecule. While damage from one freeze thaw cycle is minimal, repeated cycles can cause more damage than chemical degradation caused by storing at warmer refrigeration temps.

You can only be certain you've essentially stopped all degradation at cryofreezer temps, which are well below the lowest possible thawing temp of the moisture. -80c is considered guaranteed, , while pharma often uses -100c for an added margin of safety against degradation in very long term storage.

 

[Diixencider]

The colder the temp, the slower chemical degradation happens. The colder, the better.

But the problem with freezing is physical degradation. All peptides have a residual moisture content. This moisture is bound up with the protein, and when ice crystals expand, they can physically break some peptide molecule. While damage from one freeze thaw cycle is minimal, repeated cycles can cause more damage than chemical degradation caused by storing at warmer refrigeration temps.

You can only be certain you've essentially stopped all degradation is at cryofreezer temps, which are well below the lowest possible thawing temp of the moisture. -80c is considered guaranteed, , while pharma often uses -100c for an added margin of safety against degradation in very long term storage.

Yeah i don't think my freezer gets that cold lmao. I'll prollt just keep inventory smaller for now. That makes sense though with the moisture freezing and actually damaging the product cuz water expands when frozen

 

[Ghoul]

Yeah i don't think my freezer gets that cold lmao. I'll prollt just keep inventory smaller for now. That makes sense though with the moisture freezing and actually damaging the product cuz water expands when frozen

What confuses people is they assume 0c (32f) is the freezing temp, and their freezer is well below that. So despite temp variation of a few degrees, there's no risk of freeze/thaw.

0c is the freezing temp of *pure* water. When there are solutes present, freezing temp is lower. Like salt on road ice.

Realistically that means a freezing temp range of -10c to -60c for almost all peptides.

So if your freezer is set to -20c, but swings between -17c and -22c, and your peptide residual moisture freezes at some temp within that range, like -18c, you're freezing and thawing it multiple times a day, for years.

Without knowing this ice transition temp, essentially impossible. refrigeration is safer as long as the time in storage is reasonably short like a year or so.

 

[Delux]

What about a freezer that doesnt have a frost free cycle? Could that be slightly more beneficial than the refrigerator for long term 2+ years storage?

 

[Diixencider]

What confuses people is they assume 0c (32f) is the freezing temp, and their freezer is well below that. So despite temp variation of a few degrees, there's no risk of freeze/thaw.

0c is the freezing temp of *pure* water. When there are solutes present, freezing temp is lower. Like salt on road ice.

Realistically that means a freezing temp range of -10c to -60c for almost all peptides.

So if your freezer is set to -20c, but swings between -17c and -22c, and your peptide residual moisture freezes at some temp within that range, like -18c, you're freezing and thawing it multiple times a day, for years.

Without knowing this ice transition temp, essentially impossible. refrigeration is safer as long as the time in storage is reasonably short like a year or so.

Damn dude thanks for the knowledge I didn't think about temp variance either. You the man for that

 

[Ghoul]

What about a freezer that doesnt have a frost free cycle? Could that be slightly more beneficial than the refrigerator for long term 2+ years storage?

Frost free freezers are 100% no good. We're taking a 10-20c swing on a regular basis.

At best a chest freezer that's never opened and fully packed might have a swing of 2c. But in reality it's more likely to be 5c depending on where that measurement's being taken.

If the swing range is above or below the freeze point of the residual moisture in a peptide, it's fine. But we have no idea if any given peptide is within that range, subject to repeated freeze thaw cycles. Only getting below the lowest freeze point likely to be encountered, -60c, can you be sure you're not inducing more damage than by just refrigerating.

 

[Delux]

Yeah I hear you for frost free freezers that temperature cycle to keep the frost from building up. I was talking about freezers that DONT have that cycle that maintain a much smaller temperature swing, usually only ±2°F to ±5°F.

If this type of freezer is set to -7.6℉ on its coldest setting, and maintains a freezing temperature at all times (even with the door opening from time to time and the temperature swing accounted for I doubt things would go to 32F going out of the freezing temperature range) wouldn't that overall be a benefit to the peptide stability?

 

[Ghoul]

Yeah I hear you for frost free freezers that temperature cycle to keep the frost from building up. I was talking about freezers that DONT have that cycle that maintain a much smaller temperature swing, usually only ±2°F to ±5°F.

If this type of freezer is set to -7.6℉ on its coldest setting, and maintains a freezing temperature at all times (even with the door opening from time to time and the temperature swing accounted for I doubt things would go to 32F going out of the freezing temperature range) wouldn't that overall be a benefit to the peptide stability?

Retread my post above. 32f isn't the freezing temp of residual moisture in peptides.

 

[Delux]

Retread my post above. 32f isn't the freezing temp of residual moisture in peptides.

Ah OK makes sense, so really if we are talking the most ideal setup outside of cryo freezing its maintaining a temperature probably around maybe -5C to keep from going into the -20C range that would cause degradation of the solutes and also accounting for the fridge/freezer swinging the temp over -20C.