kidney health

[just some dude]

what is your protocol for supporting your kidneys regardless if you’re on a cycle or not? year round.

 

[Ghoul]

what is your protocol for supporting your kidneys regardless if you’re on a cycle or not? year round.

Telm and Cilnidipine.

A twofer, BP control as well as a potent combo for kidney health, from preserving healthy kidneys all the way to early chronic kidney disease.

 

[just some dude]

Telm and Cilnidipine.

A twofer, BP control as well as a potent combo for kidney health, from preserving healthy kidneys all the way to early chronic kidney disease.

do you prefer cilnidipine over amlopodine? i just ordered a bunch of ancillaries and addressed just about every pathway i needed to but this just reminded me about calcium channel blockers. for some reason ever since ive been taking vitamin k2 (mk-7) i’ve disregarded that pharma pathway even tho i noticed really good results with them.

 

[just some dude]

shit, i just answered my own question. i researched for a sec and found that yeah, that’s the most kidney protective calcium channel blocker by far. wonder if i can still add it to my order …

edit: it’s not there! i’ll have to get it prescribed

 

[Eddie.]

Telm and Cilnidipine.

A twofer, BP control as well as a potent combo for kidney health, from preserving healthy kidneys all the way to early chronic kidney disease.

Ghoul, he's asking for kidney support not BP medications. I need kidney support too and my BP is 105/55, do you suggest to hop on telmisartan and cilnidipine too?

 

[just some dude]

Ghoul, he's asking for kidney support not BP medications. I need kidney support too and my BP is 105/55, do you suggest to hop on telmisartan and cilnidipine too?

omega 3s (epa+dha) for overall inflammation

astanaxin is thousand of times more potent than vitamin c in terms of antioxidant strength

but inflammation is basic. water intake, high potassium diet, taking care of your blood pressure and taking care of your inflammation. these are all basic af but what about diving into the even deeper ones

 

[just some dude]

Sure — here’s a comprehensive list of kidney protection pathways:

1. RAAS inhibition (Renin-Angiotensin-Aldosterone System)
2. Blood pressure regulation
3. Glomerular filtration barrier integrity
4. Tubulointerstitial fibrosis prevention
5. Antioxidant defense systems
6. Anti-inflammatory pathways (e.g. NF-κB inhibition)
7. Mitochondrial biogenesis and energy metabolism
8. Autophagy activation
9. Gut–kidney axis modulation
10. Endothelial function preservation
11. Proteinuria reduction
12. Podocyte protection
13. Advanced glycation end-product (AGE) suppression
14. Uremic toxin clearance
15. Hypoxia signaling modulation (e.g. HIF pathway)
16. Nitric oxide (NO) availability
17. Phosphate homeostasis
18. Lipotoxicity reduction
19. Insulin sensitivity improvement
20. Oxalate metabolism regulation
21. Complement system modulation
22. Sympathetic nervous system inhibition
23. ER stress reduction
24. Ferroptosis inhibition
25. Apoptosis regulation (e.g. Bcl-2, caspases)
26. Sirtuin pathway activation (e.g. SIRT1)
27. AMPK activation
28. TGF-β inhibition
29. Nrf2 pathway activation
30. Glyoxalase system support
31. Peroxisome proliferator-activated receptor (PPAR) activation
32. Klotho-FGF23 axis regulation
33. VEGF pathway balance
34. mTOR signaling modulation
35. Microvascular perfusion enhancement
36. Lymphangiogenesis regulation
37. Epigenetic modulation (e.g. HDAC inhibition)
38. Mineralocorticoid receptor antagonism
39. Protein translation control
40. Prostaglandin signaling

WTF

 

[Eddie.]

omega 3s (epa+dha) for overall inflammation

astanaxin is thousand of times more potent than vitamin c in terms of antioxidant strength

but inflammation is basic. water intake, high potassium diet, taking care of your blood pressure and taking care of your inflammation. these are all basic af but what about diving into the even deeper ones

Dude you don't get it, do you? On a thread which you specifically asked for kidney support and without even mentioning your blood pressure, someone comes and suggests blood pressure medications. Yes, high blood pressure can mess up your kidneys but that's not always the case.

It's not so smart saying hey, you need something good for your kidneys? Take these two BP meds (without even asking how's your BP?).

I'm already taking very potent Ω3's, vit C, B, K, D3, multivitamin, 4-8 grams of astragalus root, i'm drinking 5-6 liters of water, eating clean and my inflammation markers (WBC and CRP) are low.

 

[Ghoul]

do you prefer cilnidipine over amlopodine? i just ordered a bunch of ancillaries and addressed just about every pathway i needed to but this just reminded me about calcium channel blockers. for some reason ever since ive been taking vitamin k2 (mk-7) i’ve disregarded that pharma pathway even tho i noticed really good results with them.

I used Amlodipine (3rd gen CCB) for years, as a combo with Valsartan, then Telmasartan, without sides, but eventually, edema can develop.

Cilnidipine (4th gen) is equally effective to Amlodipine at BP reduction, but because it uniquely blocks another calcium channel, "N", instead of just "L" it:

1: Prevents the reflexive heart rate increase that happens when BP is reduced by other meds, so lower resting heart rate.

2: Relaxes blood vessels in a more balanced way than other CCBs, preventing the edema / water retention Amlodipine can cause in some people, or after many years of use (this is the main reason patients get switched from cheaper Amlodipine to more expensive Cilnidipine....imo better to avoid it to begin with with).

3. Reduces internal kidney pressure, improving function and preventing damage. Lowers protein excretion.

4. Weakens the link between psychological stress, blood pressure, and heart stress by inhibiting norepinephrine release .

5. Significantly improves endothelial function vs Amlodipine, Amlodipine improves blood vessel function slightly, but Ciln also reduces oxidants and boosts nitrous oxide levels within blood vessels, keeping them more supple and flexible which Amlodipine doesn't do.

5. Very slightly lowers triglycerides, and raises HDL. Not a major effect, but Amlodipine doesn't do this at all. A nice bonus.

6. In my case it relieved symptoms of Reynaud's syndrome. I had a couple of toes that would go numb, particularly in cold temps. This is an exaggerated response by tiny arteries to cold exposure and stress. They spasm, reducing blood flow, causing cramping, numbing, etc. It can happen in hands as well, and be severe in some. It's estimated 20% of adults have this, most
undiagnosed, but considered an annoyance rather than a serious condition. Cilnidipine is going to be marketed in the US (finally) as a name brand drug for this purpose. The first treatment for it.

You need to use 2x the dose for equivalent Amlodipine BP reduction, ie, 5mg Amlodipine=10mg Ciln.

I use a tiny combo Telm 40mg / Ciln 20mg tab that keeps my BP consistently around 115/70, from 155/90, with no sides.

 

[BamaCrazy]

Ghoul, he's asking for kidney support not BP medications. I need kidney support too and my BP is 105/55, do you suggest to hop on telmisartan and cilnidipine too?

The guy never listens. He recommends pharmaceuticals first, lifestyle and diet changes last (if at all). People who recommend pharmaceuticals that treat conditions you don’t have should be ignored.

 

[Ateam2023]

I used Amlodipine (3rd gen CCB) for years, as a combo with Valsartan, then Telmasartan, without sides, but eventually, edema can develop.

Cilnidipine (4th gen) is equally effective to Amlodipine at BP reduction, but because it uniquely blocks another calcium channel, "N", instead of just "L" it:

1: Prevents the reflexive heart rate increase that happens when BP is reduced by other meds, so lower resting heart rate.

2: Relaxes blood vessels in a more balanced way than other CCBs, preventing the edema / water retention Amlodipine can cause in some people, or after many years of use (this is the main reason patients get switched from cheaper Amlodipine to more expensive Cilnidipine....imo better to avoid it to begin with with).

3. Reduces internal kidney pressure, improving function and preventing damage. Lowers protein excretion.

4. Weakens the link between psychological stress, blood pressure, and heart stress by inhibiting norepinephrine release .

5. Significantly improves endothelial function vs Amlodipine, Amlodipine improves blood vessel function slightly, but Ciln also reduces oxidants and boosts nitrous oxide levels within blood vessels, keeping them more supple and flexible which Amlodipine doesn't do.

5. Very slightly lowers triglycerides, and raises HDL. Not a major effect, but Amlodipine doesn't do this at all. A nice bonus.

6. In my case it relieved symptoms of Reynaud's syndrome. I had a couple of toes that would go numb, particularly in cold temps. This is an exaggerated response by tiny arteries to cold exposure and stress. They spasm, reducing blood flow, causing cramping, numbing, etc. It can happen in hands as well, and be severe in some. It's estimated 20% of adults have this, most
undiagnosed, but considered an annoyance rather than a serious condition. Cilnidipine is going to be marketed in the US (finally) as a name brand drug for this purpose. The first treatment for it.

You need to use 2x the dose for equivalent Amlodipine BP reduction, ie, 5mg Amlodipine=10mg Ciln.

I use a tiny combo Telm 40mg / Ciln 20mg tab that keeps my BP consistently around 115/70, from 155/90, with no sides.

View attachment 331517

Kidneys Not BP ,, stick to the topic will ya,,

 

[Ghoul]

Ghoul, he's asking for kidney support not BP medications. I need kidney support too and my BP is 105/55, do you suggest to hop on telmisartan and cilnidipine too?

No, he asked:

what is your protocol for supporting your kidneys regardless if you’re on a cycle or not. year round.

Understand the difference?

That's MY protocol.

The correct reply to the question "what is your protocol?".

Maybe, if he has to address hypertension as well, like many of us do, it provides a solution he hadn't considered.

Maybe it'll be useful in the future.

Maybe it's not relevant in his case.

But that's MY protocol, which is what he asked for.

I never suggested he use it if his BP is well controlled.

 

[Ateam2023]

Kidneys Not BP ,, stick to the topic will ya,, View attachment 331519View attachment 331519View attachment 331519

That was 2 more gtfo than I intended, but you get my gist,, Ghoul why must you insist on just "being that1 guy" ? Were talking kidneys here, AND bp does have bearing on kidney health, but you go off on some bp rant , , Kideys here, stay on topic,,

 

[Ateam2023]

omega 3s (epa+dha) for overall inflammation

astanaxin is thousand of times more potent than vitamin c in terms of antioxidant strength

but inflammation is basic. water intake, high potassium diet, taking care of your blood pressure and taking care of your inflammation. these are all basic af but what about diving into the even deeper ones

this is very interesting to me also ,and as i dive down the "rabbit hole" of kidney health and find it all very COMPLEX, ive really been delving into Astragulus as a "bandaid" for me atm, just got preliminary findings of stage three ckd a couple weeks ago, i have yet to speak to the nephrologist, i've been referred by pcp because on kidney ultra sound thats when they confirmed and also according to bloodwork aligning with the diagnosis, but i am an early stage 3 which can absolutely be stopped and "possibly" reversed a bit , tbd,, sorry for the rant op,,

 

[Ateam2023]

Sure — here’s a comprehensive list of kidney protection pathways:

1. RAAS inhibition (Renin-Angiotensin-Aldosterone System)
2. Blood pressure regulation
3. Glomerular filtration barrier integrity
4. Tubulointerstitial fibrosis prevention
5. Antioxidant defense systems
6. Anti-inflammatory pathways (e.g. NF-κB inhibition)
7. Mitochondrial biogenesis and energy metabolism
8. Autophagy activation
9. Gut–kidney axis modulation
10. Endothelial function preservation
11. Proteinuria reduction
12. Podocyte protection
13. Advanced glycation end-product (AGE) suppression
14. Uremic toxin clearance
15. Hypoxia signaling modulation (e.g. HIF pathway)
16. Nitric oxide (NO) availability
17. Phosphate homeostasis
18. Lipotoxicity reduction
19. Insulin sensitivity improvement
20. Oxalate metabolism regulation
21. Complement system modulation
22. Sympathetic nervous system inhibition
23. ER stress reduction
24. Ferroptosis inhibition
25. Apoptosis regulation (e.g. Bcl-2, caspases)
26. Sirtuin pathway activation (e.g. SIRT1)
27. AMPK activation
28. TGF-β inhibition
29. Nrf2 pathway activation
30. Glyoxalase system support
31. Peroxisome proliferator-activated receptor (PPAR) activation
32. Klotho-FGF23 axis regulation
33. VEGF pathway balance
34. mTOR signaling modulation
35. Microvascular perfusion enhancement
36. Lymphangiogenesis regulation
37. Epigenetic modulation (e.g. HDAC inhibition)
38. Mineralocorticoid receptor antagonism
39. Protein translation control
40. Prostaglandin signaling

WTF

ahh you found the "rabbit hole",, lol its so damn complex ,

 

[Ateam2023]

No, he asked:



Understand the difference?

That's MY protocol.

The correct reply to the question "what is your protocol?".

Maybe, if he has to address hypertension as well, like many of us do, it provides a solution he hadn't considered.

Maybe it'll be useful in the future.

Maybe it's not relevant in his case.

But that's MY protocol, which is what he asked for.

I never suggested he use it if his BP is well controlled.

Alot of "My" in there,,, your so "Self Centered"! Ahaahaa

 

[just some dude]

ahh you found the "rabbit hole",, lol its so damn complex ,

it really is! but shit it might be worth going down it. the kidneys have always scared me because they’re so sensitive.. it’s like, here’s your glutathione enhancing supplements for your liver… don’t go back and forth with the healing and fucking it up too many times and you’ll be good.

then with the kidneys it just seems like it’s 100x more complicated. i guess they’re just extremely vulnerable. 40 different pathways is ridiculous though.

this is very interesting to me also ,and as i dive down the "rabbit hole" of kidney health and find it all very COMPLEX, ive really been delving into Astragulus as a "bandaid" for me atm, just got preliminary findings of stage three ckd a couple weeks ago, i have yet to speak to the nephrologist, i've been referred by pcp because on kidney ultra sound thats when they confirmed and also according to bloodwork aligning with the diagnosis, but i am an early stage 3 which can absolutely be stopped and "possibly" reversed a bit , tbd,, sorry for the rant op,,

sorry to hear that. but yeah, shit, seems like you’re right in the middle of all of that. i guess out of all the million different pathways you could narrow it down to a maybe top 5 or top 10 most important.

i’ve been on and off with the astragulus but to be honest i have no clue what the hell it even does for the kidneys i just always hear it as the main kidney supplement besides lifestyle changes. i’ll have to dive deeper into the rabbit hole later today. definitely not doing any crazy shit like lowering my protein though, maybe just. less reckless shit hahah

 

[just some dude]

Dude you don't get it, do you? On a thread which you specifically asked for kidney support and without even mentioning your blood pressure, someone comes and suggests blood pressure medications. Yes, high blood pressure can mess up your kidneys but that's not always the case.

It's not so smart saying hey, you need something good for your kidneys? Take these two BP meds (without even asking how's your BP?).

I'm already taking very potent Ω3's, vit C, B, K, D3, multivitamin, 4-8 grams of astragalus root, i'm drinking 5-6 liters of water, eating clean and my inflammation markers (WBC and CRP) are low.

i got it i just wasn’t in the mood to argue, just trying to learn more about what steps we can take to protect our kidneys. bp and calcium are very valid pathways. but yeah, i get where you’re coming from as well.

 

[Ateam2023]

it really is! but shit it might be worth going down it. the kidneys have always scared me because they’re so sensitive.. it’s like, here’s your glutathione enhancing supplements for your liver… don’t go back and forth with the healing and fucking it up too many times and you’ll be good.

then with the kidneys it just seems like it’s 100x more complicated. i guess they’re just extremely vulnerable. 40 different pathways is ridiculous though.



sorry to hear that. but yeah, shit, seems like you’re right in the middle of all of that. i guess out of all the million different pathways you could narrow it down to a maybe top 5 or top 10 most important.

i’ve been on and off with the astragulus but to be honest i have no clue what the hell it even does for the kidneys i just always hear it as the main kidney supplement besides lifestyle changes. i’ll have to dive deeper into the rabbit hole later today. definitely not doing any crazy shit like lowering my protein though, maybe just. less reckless shit hahah

i kind of cut/lowered out a few "unnecessary" supplements, upped my water intake , take 4-5 g daily of Astragulus and also i drink my electrolytes every morning to start my day, and until i have talked to the nephrologist , im not gonna stress on it , i swear the week or so after finding this ckd out , i was a stressed out mess, which isn't good for obvious reasons, i have a thread i started about "bloodwork help" and i got ALOT of positive feedback/support , Im glad i got a Cystatin c bloodtest, its what alerted me ,,

 

[Ghoul]

i got it i just wasn’t in the mood to argue, just trying to learn more about what steps we can take to protect our kidneys. bp and calcium are very valid pathways. but yeah, i get where you’re coming from as well.

Two basic types of people in a conversation like this. Those who seek to expand knowledge, and those who diminish, because they have nothing substantial to offer.

The argument by these clowns is that somehow, had this info not been presented, we'd be better off.

~80% of kidney injuries related to AAS have BP as the primary cause or major contributing factor.

~90% of injuries in non-diabetic, non-AAS users.

So how is this an unrelated to the topic?

Is "kidney support" only supposed to focus on the 10-20% of non-BP related causes on or off cycle?

OK, on cycle AAS cytotoxicity injures cells in the kidney directly. But this isn't what causes permanent kidney damage. It's the fibrosis scarring those poisoned cells lead to. Telmasartin inhibits fibrosis completely independent of BP reduction. That's one of half of dozen non-BP related renal protective effects of the combo I mentioned. I didn't discover this. It's probably one reason why Telm has been a preferred blood pressure med by BBs for years.

Or maybe we should only discuss "lifestyle" interventions, and not what actually works to prevent harm? Maybe if someone drinks enough water it'll dissolve kidney scar tissue.