ve79
Member
Hey everyone I noticed everyone is for the most part sold out of primo. Is this because the raws for primo are hard to come by or too expensive for people sources to make? I'm just curious?
MESO-Rx
Anabolic Steroids
What's going on with primo?
- Thread starter ve79
- Start date
TheScholarOfBrew
Subscriber
Let me once again remind everyone
Primo and mast NEED the same manufacturing process as fentanyl. There is NO fresh mast or ( maybe they are risking it for primo i have heard talks of this) primo being produced.
Im not fear mongering or pushing some agenda. This is the reality. If people stopped being dependent on these compounds and found alternatives to replace them. Alot of the supply and hording might reach a balancing point.
I suggest for those looking for masts effects to try proviron injectable. It provides many close effects to your best friend mast but the plus here is its plentiful and when injected very very very cost effective!
Its an alternative you might miss due to its high cost orally. But it wont be suddenly dried up as its a pharmaceutical api! Win win win.
Primo and mast NEED the same manufacturing process as fentanyl. There is NO fresh mast or ( maybe they are risking it for primo i have heard talks of this) primo being produced.
Im not fear mongering or pushing some agenda. This is the reality. If people stopped being dependent on these compounds and found alternatives to replace them. Alot of the supply and hording might reach a balancing point.
I suggest for those looking for masts effects to try proviron injectable. It provides many close effects to your best friend mast but the plus here is its plentiful and when injected very very very cost effective!
Its an alternative you might miss due to its high cost orally. But it wont be suddenly dried up as its a pharmaceutical api! Win win win.
Team Syntex
en.m.wikipedia.org
www.acs.org
Syntex - Wikipedia
Russell Marker Creation of the Mexican Steroid Hormone Industry - Landmark - American Chemical Society
American Chemical Society: Chemistry for Life.
BP_6
Member
I am curious since I am not a chemist. What specific pre-cursor is required to make methenolone and drostanolone that is controlled as a precursor?
An Efficient, Optimized Synthesis of Fentanyl and Related Analogs - PMC
The alternate and optimized syntheses of the parent opioid fentanyl and its analogs are described. The routes presented exhibit high-yielding transformations leading to these powerful analgesics after optimization studies were carried out for each ...
pmc.ncbi.nlm.nih.gov
TheScholarOfBrew
Subscriber
It's just the starting material at least a reaction step needed. Before a special strain of fermentation was used they used to get there via diosgenin. But for mast and primo. It requires an addition of precursor used in fentanyl production too.
Will a work around be found? Maybe. They do this all the time on BBgate.
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Would be wild for a domestic operation to step in just for the principle of it all. Seems like too much risk / reagents / opportunity cost.
TheScholarOfBrew
Subscriber
Hehehhehe umm yeah..... Hehehe would be super funny wouldn't it. Would absolutely shock everyone too. Wonder who will do it hehehehehehhehehehehe. I hope he has a passion for this subject and a can do attitude!
Name the common precursor between primo and fentanyl, please.
IndividualMan
Member
and it is not a primo precursor, it is used in a ?reduction? dont quote me on that, it has been a few days since i read up on the topic
How is that related to methenolone and drostanolone though?
IndividualMan
Member
Idk man, Ochem is hard reagents are not easily interchangable in some cases.
But it could also be hat the chinese vendors are all conspiring against you specifically to keep you from getting your much needed primo & mast. And I am also lying to you. And @TheScholarOfBrew is also lying to you. Its all a big conspiracy, and your post saying
But it could also be hat the chinese vendors are all conspiring against you specifically to keep you from getting your much needed primo & mast. And I am also lying to you. And @TheScholarOfBrew is also lying to you. Its all a big conspiracy, and your post saying
uncovered it all. good job mr detective man.
eery
Member
AI at your service:
1. Common Starting Materials & Precursors
For Methenolone (Primobolan) Enanthate:
- 1-Dehydroepiandrosterone (1-DHEA) – A modified DHEA derivative.
- Epiandrosterone – A key intermediate.
- 17α-Methyl-5α-androst-1-en-3-one-17β-ol – Core structure for methenolone.
- 17α-Methyltestosterone – Sometimes used as a precursor.
For Drostanolone (Masteron) Enanthate:
- Dihydrotestosterone (DHT, 5α-androstan-17β-ol-3-one) – Primary precursor.
- 2α-Methyl-5α-androstan-17β-ol-3-one – Direct intermediate.
- Androstenedione – Can be converted into DHT derivatives.
2. Key Reagents & Chemicals for Synthesis
General Steroid Chemistry Reagents:
- Oxidizing Agents:
- PCC (Pyridinium Chlorochromate) – For alcohol oxidation.
- Jones Reagent (CrO₃/H₂SO₄) – Strong oxidation.
- NaOCl (Bleach) / TEMPO – Mild oxidation.
- Reducing Agents:
- Sodium Borohydride (NaBH₄) – Selective reduction.
- Lithium Aluminum Hydride (LiAlH₄) – Strong reduction.
- Methylation Agents (for 17α-methylation in Methenolone):
- Methyl Iodide (CH₃I) – Adds methyl group.
- Dimethyl Sulfate (DMS) – Alternative methylating agent.
- Protection/Deprotection Reagents:
- Acetic Anhydride (Ac₂O) – For temporary protection of hydroxyl groups.
- p-Toluenesulfonic Acid (TsOH) – Acid catalyst.
- Grignard Reagents (for side-chain modifications):
- Methylmagnesium Bromide (CH₃MgBr) – Used in some steroid modifications.
- Enzymatic Catalysts (for selective reactions):
- Baker’s Yeast – Sometimes used for stereoselective reductions.
3. Solvents Used in Synthesis
- Polar Solvents:
- Methanol (MeOH), Ethanol (EtOH) – For dissolving steroids.
- Acetone – Common solvent for reactions.
- Tetrahydrofuran (THF) – For Grignard reactions.
- Non-Polar Solvents:
- Dichloromethane (DCM), Chloroform (CHCl₃) – For extractions.
- Hexane, Petroleum Ether – For purification.
- Aprotic Solvents:
- Dimethylformamide (DMF), Dimethyl Sulfoxide (DMSO) – For certain reactions.
4. Esterification (Making the Enanthate Ester)
To convert the free steroid (Methenolone or Drostanolone) into its enanthate ester, the following are needed:- Enanthic Acid (Heptanoic Acid, C₇H₁₄O₂) – The fatty acid for esterification.
- Dicyclohexylcarbodiimide (DCC) – Coupling agent.
- 4-Dimethylaminopyridine (DMAP) – Catalyst for ester formation.
- Sulfuric Acid (H₂SO₄) or Thionyl Chloride (SOCl₂) – Alternative activation methods.
5. Purification & Isolation
- Silica Gel (for Column Chromatography) – Purifies crude product.
- Activated Charcoal – Removes impurities.
- Ethyl Acetate (EtOAc) / Hexane Mixtures – For TLC and column chromatography.
- Rotary Evaporator – Removes solvents under vacuum.
- Recrystallization Solvents (e.g., Ethanol, Acetone) – For final purification.
6. Common Underground Synthesis Shortcuts
Since full steroid synthesis is complex, underground labs often use:- Pre-made steroid powders (Methenolone Base / Drostanolone Base) – Purchased from illicit sources, then esterified.
- "Designer" steroid intermediates – To avoid controlled precursor laws.
- Black-market enanthic acid & esterification kits – Sold for homebrew steroid production.
All for educational and entertainment purposes only, dont use any if this information or put it to practice
TheScholarOfBrew
Subscriber
You caught me
I was actual a fud astrotuffer pushed by the pharmaceutical companies to push for more proviron!!!
Actually, the shortage of Primo (methenolone) and Mast (drostanolone) isn’t random. Both of them depend on specific chemicals to make their ester forms
.
acetic anhydride for Primo (acetate ester) and propionic anhydride or propionyl chloride for Mast (propionate ester). These aren’t just basic lab reagents anymore
.... they’ve been pulled into the spotlight because they’re also used in fentanyl synthesis.
What’s happening now is the DEA and other regulators are cracking down hard on anything tied to fentanyl production. Propionic anhydride is already a DEA List I chemical, and propionyl chloride is in the process of being scheduled the same way. That directly affects Mast production. Acetic anhydride, which is used in both Primo and heroin synthesis, is a DEA List II chemical and has been tightly monitored for years.
So yeah, Primo and Mast share some synthesis steps or reagents with fentanyl, not because they’re similar drugs, but because the same industrial chemicals are used in their production. When those chemicals get regulated, the bottleneck affects everyone... including legit pharma operations and UGLs. That’s why we’re seeing availability issues now. It's a supply chain casualty of the fentanyl crackdown.
Cleared it up for ya?
That’s horseshit.
They are made in china so the DEA/FDA has no authority there.
Those reagents you mentioned for one are not involved in the synthesis of the enanthate ester.
Also they are only involved in the trivial esterification rather than the synthesis of the actual compound.
Also that would therefore apply to all testosterone esters, and countless non fentanyl drugs and chemical compounds as these are standard reagents used for many things…
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