Ateam2023
Member
geeeez , what a let down,,
MESO-Rx
Anabolic Steroids
The generic vs pharma GH discussion
- Thread starter justaphan
- Start date
geeeez , what a let down,,
AlexDavis43
Member
Well at least now we know it's an indisputable fact that misfolded GH is what causes cloudy GH
¯\_(ツ)_/¯
therefore 99.99% of GH vials contain good GH
and sending a vial in for NMR without knowing if it's gonna be cloudy upon reconstitution is pointless so how's that gonna work, specifically?
Spaceman Spiff
Subscriber
AlexDavis43
Member
Was it one of these?
The pharmacokinetic and pharmacodynamic properties and short-term outcome of a novel once-weekly PEGylated recombinant human growth hormone for children with growth hormone deficiency - PMC
To investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of Y-shape branched PEGylated recombinant human growth hormone (YPEG-rhGH) and evaluate its short-term efficacy and safety in children with growth hormone deficiency (GHD). A total ...pmc.ncbi.nlm.nih.gov
Compares Chinese pharma vs Norditropin.
Nope. Growth velocity is the ultimate clinical endpoint but this study was comparing structural characteristics of the GH molecule (pharma vs UGL??).
Now I'm kinda thinking there wasn't an actual study, only a Perplexity answer mixed around in his brain with some stuff he read on here (no offense banana man).
NMR is really expensive and imo what's the fucking point?
Banana Joe
Member
No offense taken! That very well might be the case, though I found this thread only a day or two ago, and I looked into that stuff maybe ten days ago. Would have kept notes, had I known this might be a groundbreaking finding, LOL.
But I was just bored and decided to find some proof, that Kurt Havens is making unsubstantiated claims regarding Serostim and Chinese rHGH...
My entry point for the search was the use of Manitol vs other sugars, I only later learned about misfolded rHGH as a possible explanation for Chinese one not being as effective.
What seemed clear to me though is that his reasoning for using a different sugar as binding agent (or whatever the proper term is?!) is bullshit, but again, I didn't take notes why exactly, and will therefore refrain from talking out of my ass again!
I will try to find it again, but unless I will post a link - consider it a figment of my AI fueled imagination!
Last edited:
bananafeet
Member
View: https://youtu.be/HIrU8hc4-bQ?si=HfFT33HDSRN0QA98
Speaking of Kurt Havens. Claims a client had his kidneys wrecked due to Chinese HGH. I think he is mispronouncing Poloxamer 188 and claimed it was the cause.
I thought Chinese HGH only had manitol added ...
Spaceman Spiff
Subscriber
1.32 creatinine? fuck thats nothing.
"starting to go up" where is the rest of the data or why cant he present a line graph to show a trend? all from HGH? so many other factors could be involved.
For a PHD candidate this is pathetic.
Ateam2023
Member
no one really knows whats in china hgh, lol its all just a mystery, but it seems to be working for me at least,,
Spaceman Spiff
Subscriber
brutalbuilt
Member
literally everyone takes generic hgh with no kidney issues lmao
idk why they hate on generics so much
Try 18ius of setostim and 18ius of underground GH and you will see what happens to your physique.
eery
Member
im starting to wonder if they are getting paid by certain sources to promote certain things at this point.
AlexDavis43
Member
All evidence suggests they're broke & unemployed
AlexDavis43
Member
What's your thoughts re: account farming on the AAS forums?
AlexDavis43
Member
Be specific.
Are you talking about people who join other boards with a different handle and try to remain unrelated from their other accounts?
Does this matter: malicious intent vs "just trying to start over" ?
Yeah, good point. Intent so important as well as context I have to think.
What's your opinion? For an entity with non malicious intent or good intent, do the ends justify the means?
Ateam2023
Member
Shit, some of these guys pulling 600-700 igf1 numbers on very minimal doses of ugl hgh, i am not one of them , i could only imagine the comparison like you said,
bigdaddyandfriends
Member
Creatinine is nearly useless in bodybuilders, unless it registers clearly in the renal failure range, because of high muscle turnover and nearly universal consumption of multiple daily grams of creatine. That's why cystatin-C is a far superior marker, in almost every case the eGFR will e significantly higher using cystatin-C versus creatine.
In my field where we administer potentially renotoxic contrast agents for scans, < 1.49 is considered 'normal', 1.5 - 1.99 'borderline', and >2.0 'no go' where contrast injection = high likelihood of AKI.
Obviously most important thing in maintaining renal health on PEDs is blood pressure control and hydration. Beyond that SS-31 (elamipretide), SGLT2 drugs i.e. empoglaflozin, and astragaloside IV are all beneficial for long term renal health.
In my field where we administer potentially renotoxic contrast agents for scans, < 1.49 is considered 'normal', 1.5 - 1.99 'borderline', and >2.0 'no go' where contrast injection = high likelihood of AKI.
Obviously most important thing in maintaining renal health on PEDs is blood pressure control and hydration. Beyond that SS-31 (elamipretide), SGLT2 drugs i.e. empoglaflozin, and astragaloside IV are all beneficial for long term renal health.
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