nicksampson123
New Member
On cycle HDL is low at 27 with normal LDL. Should I wait until I cruise to reassess?
MESO-Rx
Anabolic Steroids
when to add in ezetimibe?
- Thread starter nicksampson123
- Start date
Ghoul
Member
Why wait?
Ezetimebe protects your long term vascular health without metabolic compromises or any significant risk of sides.
Ezetimebe protects your long term vascular health without metabolic compromises or any significant risk of sides.
Eddie.
Member
Elaborate normal LDL. I’d start now, even 5mg per day would be beneficial.
Ouch
Member
Eh, depends on how you define significant. I’ve tried Ez 3 times now and ended up with god awful hemorrhoids each time. Never had them before and brother I’m here to testify that I consider them significant, at least in terms of quality of life.
Ghoul
Member
I can sympathize with the hell of hemorrhoids (not from too many experience thank god), and not doubting your experience, but there's no known link between ezetimebe and hemmeroids. The worst sides are very mild GI issues like gas or diarrhea at the start that usually go away.
If you're getting those symptoms, I'd think the root of your problem is on your toilet paper holder.
Spring for the double ply Charmin Ultra Soft brother.
Ouch
Member
Lmao I wish it was that easy. What it is is a by-product of said stomach distress. In my case making it damn near impossible to take a regular shit.
Maybe tmi but I just wanted to chime in with my experience. But by all means if no experienced side effects I agree, no downside to starting the Ez now or anytime.
Ghoul
Member
For those who don't know, the way Eze lowers cholesterol is pretty cool.
It blocks the absorption of cholesterol through your intestines.
"But I thought dietary cholesterol, like eggs. doesn't raise blood cholesterol!"
This is true.
The liver synthesizes cholesterol, dumps it into the intestines, and then it's absorbed into blood.
So eze interrupts this process and you end up shitting out a portion of the cholesterol you would've otherwise reabsorbed into your bloodstream.
nicksampson123
New Member
90 on a 0-99 ref
BP_6
Member
Ezetimbie is an excellent drug. Very few sides if any in most people. The standard dose is 10mg. Not generally lower or higher. I would just go with the standard 10mg dose.
Ghoul
Member
I'm involved in some longevity science forums. follow the latest cardiology developments, etc. and just FYI, LDL above 50-70 means you're almost certainly laying down a base of plaque in your arteries. It may be slow now, but if you get below 70 you'll reduce accumulation down to the level groups who typically never get heart attacks or strokes have.
In a few years it's likely treatment standards will be updated to aggressively get LDL below 70 starting at age 25. That's where the major cardio associations seem to be going.
Meso never fails to blow my mind. I’ve got Bempesta EZ on the way to stack with rosuvastatin, feeling all smart and proactive - and then I read someone ended up with raging hemorrhoids from it. I haven’t even opened the box yet and I’m already clenching. This forum is wild… one day you’re optimizing lipids, the next you’re Googling donut pillows.
Ghoul
Member
Ouch
Member
You’re talking about the friendly exterior type.
The real fun ones are inside the grand canyon
Ouch
Member
Lmmfao. Best advice is start with EOD or break in half and try 5mg per day. It’s effective at that dose, proven on my bloodwork 2 times.
And also…if it ain’t coming out easy give up the battle for the sake of the war!
explodingHeart
Member
Aren't a good chunk of the population hyper responders to dietary cholesterol?
Anyway, the current trend on social media is for carnivore dieter types to say high LDL is a good thing and statins are "evil". (I think that's idiotic of course)
Ghoul
Member
Eze blocks dietary cholesterol as well, it's just that the amount is dwarfed by what's produced by the liver, that's why they say dietary "doesn't matter".
As far as statins...I was prescribed 2 different statins long ago, both were debilitating, so I just gave up on lipid control.
I finally got serious about long term health, Rosuvastatin trial same muscle pain as the other two, which got me a prescription for Repatha as statin intolerant.
Now first results after stacking Repatha, Ezetimebe, Pitavastatin 4mg.
APO B 160 -> 29
LDL 160 -> 27
HDL 49 -> 62
Non-HDL-C 101 -> 28
No sides.
I've had baseline imaging. CTA and CIMT (MDSave) and will monitor plaque regression by having it repeated in a year.
BP_6
Member
Those are really good numbers.
Ghoul
Member
Also taking Vitamin K-2 (mk7) to redirect calcium from arteries to bones to delay calcification, so regression window stays open as long as possible.
Icosapent Ethyl (vascepa) "Super Fish Oil". 100% EPA, prescription grade intense vascular anti inflammatory.
So we'll see. Trials show regression starts around 6 months after dropping below 50 LDL, peaks between month 12 and 24, then calcium score starts rising and regression drops off.
explodingHeart
Member
debilitating? at what dose? I've been microdosing rosuvastatin at 10mg weekly without noticing anything. Simply for the anti-inflammatory benefits.
But I have some weird LDL thing going on where mine is low 30s on only 5mg ezetimibe.
The key is building a solid mind-muscle connection...
